Optimizing antiphospholipid antibody testing: a real-world analysis of appropriateness and resource utilization [0.03%]
抗磷脂抗体检测的优化：适当性和资源利用的实际分析
Silvia Grazietta Foddai,Maria Infantino,Mariangela Manfredi et al.
Silvia Grazietta Foddai et al.
Efficient utilization of healthcare resources, including laboratory testing, is crucial for environmental sustainability and cost-effectiveness. The diagnosis of APS requires the presence of at least one clinical event (either an objectivel...
Multi-class machine learning-based classification of SCID-related genetic variants [0.03%]
基于机器学习的SCID相关基因变异分类方法
Ali Şahin,Gamze Sonmez,Mehmet Karaselek et al.
Ali Şahin et al.
Background: Variants of uncertain significance (VUS) represent a major diagnostic challenge in the interpretation of genetic testing results, particularly in the context of inborn errors of immunity such as severe combine...
Collagen heterogeneity: a barrier and bridge driving tumor immune microenvironment remodeling [0.03%]
胶原异质性：重塑肿瘤免疫微环境的障碍与桥梁
Yewen Xie,Pengyu Chen,Chunjian Qi et al.
Yewen Xie et al.
The tumor microenvironment (TME) is a complex system composed of the extracellular matrix (ECM) and various cell types, with collagen being one of its core components. Collagen heterogeneity profoundly influences tumor progression and the r...
Dysautonomia as a form of presentation of primary Sjögren's disease: a case series of six patients [0.03%]
一组六例以自主神经功能紊乱为主要表现的原发性舍格伦综合征患者临床分析
Emilio Godínez-Lazarini,Erik Cimé-Aké,Mitzi Peña-Ojeda et al.
Emilio Godínez-Lazarini et al.
We present six patients with dysautonomia secondary to primary Sjögren's disease (pSjD) and analyze the literature regarding this topic. Case series. Patients were retrospectively recruited from a tertiary center in Mexico from 2001 to 202...
Development of an in vitro method to assess the immunogenicity of biologics in the prevention of infectious diseases [0.03%]
一种用于评估生物制品在预防传染病方面的免疫原性的体外方法的研究开发
Joanna Baran,Łukasz Kuryk,Mariangela Garofalo et al.
Joanna Baran et al.
We present a series of preclinical studies focused on developing in vitro 2D and 3D models for assessing immunogenic factors in preventing infectious diseases. Human peripheral blood mononuclear cells (PBMC) and Calu-3 cell lines (bronchial...
A nasal vaccine candidate based on S2 and N proteins from SARS-CoV-2 generates a broad antibody response systemically and in the lower respiratory tract [0.03%]
基于SARS-CoV-2的S2和N蛋白的鼻腔疫苗候选物可诱导全身及下呼吸道广谱抗体反应
Yadira Lobaina,Rong Chen,Dania Vazquez-Blomquist et al.
Yadira Lobaina et al.
Since the beginning of the COVID-19 pandemic, various groups around the world have intensively worked in the development of vaccine candidates against SARS-CoV-2. Several vaccines have been approved in the past years; the majority is based ...
Sex-related differences in cell-free DNA and neutrophil extracellular traps in patients with hematologic malignancies [0.03%]
血液系统恶性肿瘤患者中游离DNA和中性粒细胞胞外陷阱的性别差异
Gaia Gnecco,Alessandro Davini,Arianna Valeriano et al.
Gaia Gnecco et al.
Cell-free DNA (cfDNA) is emerging as a promising biomarker in liquid biopsy applications for cancer, with growing interest in its potential utility also for the diagnosis, monitoring of treatment response, and detection of relapse in hemato...
Maria Matuszyńska,Agata Poniewierska-Baran,Ewa Duchnik et al.
Maria Matuszyńska et al.
Psoriasis is one of the most common chronic inflammatory skin diseases and is characterised by the uncontrolled proliferation of keratinocytes and their abnormal differentiation. Sirtuins are a group of enzymes that play an important role i...
Dissecting the heterogeneity and tumor-associated dynamics of human liver group I ILC via scRNA sequencing data [0.03%]
通过scRNA测序数据解析人类肝脏组I ILC的异质性和肿瘤相关动力学
Yumo Zhang,Jitian He,Xue Li et al.
Yumo Zhang et al.
Single-cell transcriptome analysis has made outstanding contributions to the identification of new cell lineages and the study of cancer immune microenvironment. Yet, the characterization of human liver type 1 innate lymphoid cells (ILC1s) ...
Targeting epigenetic modifications as an emerging immunotherapeutic strategy for cancers [0.03%]
表观遗传修饰在癌症免疫治疗中的作用成为研究热点
R Ilaya Kumar,Kavya Jain,Karan Raj Rai et al.
R Ilaya Kumar et al.
The field of epigenetics has significantly advanced our understanding of gene regulation in cancer, revealing dynamic modifications that do not alter the DNA sequence yet profoundly influence gene expression. These include DNA methylation, ...