The invisible agitators: exploring the viral interplay in psoriatic immune dysregulation [0.03%]
隐形的煽动者：探究银屑病免疫紊乱中的病毒相互作用
Snehasis Nayak,Budhera Nithika Reddy,Sri Vaibhav Kintali
Snehasis Nayak
This review explores the complex interplay between viral infections and psoriasis. It emphasizes how viruses like HIV, hepatitis, herpes, human papillomavirus, and SARS-CoV-2 can provoke and worsen psoriatic inflammation by disturbing immun...
Trained Immunity in sepsis: Exploring the molecular link to long-term cardiometabolic disorders [0.03%]
脓毒症中的训练免疫：探索与长期心代谢障碍的分子联系
Rijhul Lahariya,Gargee Anand,Bandana Kumari
Rijhul Lahariya
Sepsis, a life-threatening systemic infection, has long been recognized for its immediate risks, but its long-term consequences on health are increasingly evident, particularly in predisposing survivors to chronic cardiometabolic disorders ...
Sequence similarity-based candidate gene prioritization for Type 1 diabetes mellitus using moment of inertia tensor [0.03%]
基于序列相似性的转动惯量张量法寻找1型糖尿病易感基因候选基因優化方法研究
Eesam Vishnu,Nithya Chandramohan,P Manimaran
Eesam Vishnu
In this paper, the study focuses on Type 1 Diabetes Mellitus (T1D), a chronic condition that affects the insulin-producing cells of the pancreas, requiring individuals to depend on external insulin for survival. We introduce a novel method ...
Piceatannol improves autoimmune hepatitis by inhibiting the immune activities of T cells and macrophages through binding with c-Jun [0.03%]
白杨茋通过与c-Jun结合抑制T细胞和巨噬细胞的免疫活性从而改善自身免疫性肝炎
Cong Xu,Chenqi Lu,Wu Wang et al.
Cong Xu et al.
Autoimmune hepatitis (AIH) is an immune-mediated liver disease that currently lacks viable drug treatment methods. This study is to explore the role of piceatannol (PIC) in ConA-induced AIH and the related mechanisms. A mouse model of AIH w...
Associative study of human herpesvirus 8 and Kaposi's sarcoma: Mapping viral oncogenic properties and the clinical scenario in oncological patients [0.03%]
人类疱疹病毒8的关联研究及卡波西肉瘤：在肿瘤患者中绘制病毒致癌特性和临床状况
João Vitor Geisteira Oliveira da Silva,Jessica Manya Bittencourt Dias Vieira,Eidy de Oliveira Santos
João Vitor Geisteira Oliveira da Silva
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the etiological agent of Kaposi's Sarcoma (KS) and other lymphoproliferative disorders. Over three decades after its discovery, many aspects of it...
Engineering CAR-T cells for solid tumors: bispecific antigen targeting, tumor microenvironment modulation, and toxicity control [0.03%]
工程化CAR-T细胞治疗实体瘤：双特异性抗原识别、肿瘤微环境调控及毒性控制
Tanvi Premchandani,Mohammad Qutub,Amol Tatode et al.
Tanvi Premchandani et al.
Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment of hematologic malignancies, yet its efficacy in solid tumors remains limited due to antigen heterogeneity, immunosuppressive tumor microenvironments, and the...
The double-edged sword of PI3Kδ pathway-related immune dysregulation: insights from two case reports [0.03%]
PI3Kδ信号通路相关免疫紊乱的双刃剑：两例报告的启示
Marta Dafne Cabanero-Navalon,Victor Garcia-Bustos,Santos Ibanez-Barcelo et al.
Marta Dafne Cabanero-Navalon et al.
Phosphoinositide 3-kinases (PI3Ks), particularly the PI3Kδ pathway, play a crucial role in regulating immune functions. Alterations in this pathway, either as hyperactivation, such as in activated PI3Kδ syndrome (APDS), or rarely describe...
A rare autoinflammatory syndrome associated with a C2orf69 frameshift mutation: a case report [0.03%]
与C2orf69移码突变相关的罕见自身炎症综合征的病例报告
Şeyma Türkmen,Murat Hakkı Yarar,İlkay Tosun et al.
Şeyma Türkmen et al.
Monocyte plasticity and HLA-DR expression in patients with X-linked agammaglobulinemia [0.03%]
X连锁低丙球血症患者单核细胞的可塑性及HLA-DR表达
Hasibe Artac,Ayca Ceylan,Ilknur Kulhas Celik et al.
Hasibe Artac et al.
Bruton's tyrosine kinase (BTK) is expressed by innate immune cells, and it has been suggested that a lack of BTK may affect monocytes, impacting infection susceptibility and inflammatory response in patients with X-linked agammaglobulinemia...
Tyro3 upregulation is associated with muscle involvement in patients with idiopathic inflammatory myopathies [0.03%]
Tyro3上调与皮肌炎和多发性肌炎患者的肌肉受累相关
Huan Liu,Ying Ren,Qianwei Li et al.
Huan Liu et al.
Tyro3, Axl, and Mer (TAM) receptors are involved in immunity and affect the progression of several autoimmune diseases. This study investigated the potential role of TAM receptors in individuals diagnosed with idiopathic inflammatory myopat...