The osteoclast blind spot and other unresolved mechanisms in the exosomal theory of tuberculosis-induced osteoporosis [0.03%]
骨样细胞盲点及其他结核病致骨质疏松外泌理论未解机制
LiSheng Qi,QinWen Gu,Bo Chen et al.
LiSheng Qi et al.
The recent study by Zhao et al. ( Inflamm Res. 2025) proposed a novel paradigm in which exosomal miR-125b-5p from Mycobacterium tuberculosis-infected macrophages impairs osteoblast function by targeting IGF2, thereby linking pulmonary infec...
Prevalence, incidence, and mortality of autoimmune diseases among adolescents and young adults in Mexico: an analysis based on the global burden of disease study 2021 [0.03%]
基于2021年全球疾病负担研究的墨西哥青少年和年轻人自身免疫性疾病患病率、发病率和死亡率分析
Claudia Mendoza-Pinto,Pamela Munguía-Realpozo,Ivet Etchegaray-Morales et al.
Claudia Mendoza-Pinto et al.
This nationwide analysis quantified the contemporary and future burden of six autoimmune diseases (ADs)-rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes mellitus (T1DM), asthma, and psori...
RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges [0.03%]
基于RNA的癌症疫苗：机制、临床进展与转化挑战
Aya Y Al-Kabariti,Munthar Abosaoda Kadhim,Hayjaa Mohaisen Mousa et al.
Aya Y Al-Kabariti et al.
Recent advancements in vaccine technology have led to the development of RNA-based vaccines, including mRNA, circular RNA, and self-amplifying mRNA, which have emerged as a promising platform for tumor prevention and treatment. In compariso...
Hypermethylation of lysosomal-associated genes LAMP1 and LAMP2 compromises lysosome function in patients with acute lymphoblastic leukemia [0.03%]
急性淋巴细胞白血病患者中溶酶体相关基因LAMP1和LAMP2的高甲基化损害溶酶体功能
Rofaida Refaai,Sara Fouda,Doaa M Hefni et al.
Rofaida Refaai et al.
DNA methylation plays a pivotal role in the pathogenesis of Acute Lymphocytic Leukemia (ALL), a hematological malignancy marked by abnormal cellular behavior and immune dysregulation. This study aimed to investigate how alterations in DNA m...
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1 [0.03%]
MYC通过促进HRD1依赖的MFN1降解影响IgA肾病中的线粒体功能
Xueping Wu,Lei Liu,Ruiping Zhao et al.
Xueping Wu et al.
IgA nephropathy is characterized by the deposition of IgA and complement C3 in the glomerular mesangial region. Recent research has pointed out the critical role of mitochondrial damage during the occurrence and development of IgAN. During ...
Deciphering macrophage dynamics and immune evasion strategies by the intracellular bacteria [0.03%]
胞内细菌的巨噬细胞动态及免疫逃避策略
Furqan Munir,Bo He,Amna Shakoor et al.
Furqan Munir et al.
Macrophages are the constituents of the innate immune system that play an important role in the control of infections, phagocytosis, tissue surveillance, and homeostasis. Macrophages display multiple strategies to cope with the invading mic...
Glutaminase as a metabolic checkpoint in NK cell cytotoxicity: mechanistic uncertainties and translational implications [0.03%]
谷氨酰胺合成酶是NK细胞毒性的代谢检查点：机制不确定性与转化意义
DuJiang Yang,GuoYou Wang
DuJiang Yang
In their recent study, Jedlička et al. demonstrate that glutaminase (GLS) activity is indispensable for sustaining human natural killer (NK) cell cytotoxicity, positing it as a key metabolic regulator of effector function. While this work ...
Polymorphisms in STAT4 and PTPRC genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response [0.03%]
STAT4和PTPRC基因多态性与类风湿关节炎的关联：一项巴西研究及关于易感性和抗TNF药物反应的meta分析
João Locke Ferreira de Araújo,Ingrid Marins de Almeida,Pedro Augusto Silva Dos Santos Rodrigues et al.
João Locke Ferreira de Araújo et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Genetic factors play a key role in its pathogenesis and may also influence therapeutic response. ...
Meta-Analysis
Immunologic research. 2025 Nov 13;73(1):162. DOI:10.1007/s12026-025-09719-1 2025
BECN1 activator peptide Tat-beclin 1 promotes ferroptosis via the BECN1-SLC7A11 axis to inhibit NSCLC progression [0.03%]
BECN1激活肽Tat-beclin 1通过BECN1-SLC7A11轴促进铁死亡以抑制非小细胞肺癌进展
Jian Gou,Yanfang Ma,Chen Wu et al.
Jian Gou et al.
Non-small-cell lung cancer (NSCLC) is associated with high mortality. Beclin 1 (BECN1), an autophagy regulator, and ferroptosis, a lipid peroxidation-driven cell death, are both linked to cancer suppression. This study examines whether the ...
Regulatory dynamics of Th17 lymphocytes in oral squamous cell carcinoma: immune modulation and emerging immunotherapies [0.03%]
口腔鳞状细胞癌中Th17淋巴细胞的调控机制：免疫调节及新兴免疫疗法
Umesh Kumar,Mansi Kumari,Gagandeep Singh et al.
Umesh Kumar et al.
With the rapid increase in the severity and mortality of OSCC, the potential for new and effective therapies has increased significantly. Therefore, studying the immunological model of this disease will serve as a basis for developing new t...