Autoantibodies against β1-adrenoceptor induce blood glucose enhancement and insulin insufficient via T lymphocytes [0.03%]
抗β1-肾上腺素受体自身抗体通过T淋巴细胞促进血糖升高和胰岛素缺乏
Yulin Gong,Haiyan Xiong,Yunhui Du et al.
Yulin Gong et al.
Diabetes mellitus is a chronic metabolic disorder with a high morbidity and mortality, but its pathogenesis is not fully understood. An increasing amount of evidence indicates that an immune mechanism plays an important role in the pathogen...
Genetic predisposition of variants in TLR2 and its co-receptors to severe malaria in Odisha, India [0.03%]
印度奥里萨邦TLR2及其共受体变异的严重疟疾遗传易感性研究
Subhendu Panigrahi,Avishek Kar,Sagnika Tripathy et al.
Subhendu Panigrahi et al.
Although the role of TLRs signalling in malaria pathogenesis is well established, contribution of individual TLR to clinical outcome of malaria still remains inconclusive. Given the importance of TLR2 and its co-receptors in recognising dis...
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? [0.03%]
HIV-1阴性暴露者的天然免疫静息状态？来自体外TLR表达和促炎症细胞因子产生的证据
Juan C Hernandez,Georges St Laurent rd,Silvio Urcuqui-Inchima
Juan C Hernandez
Pattern recognition receptors (PRRs) are involved in direct recognition of viruses, promoting cellular activation and the production of pro-inflammatory cytokines. However, despite the reduced systemic immune activation described in HIV-1-e...
Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1β release by inhibiting NF-kB, NLRP3 inflammasome and caspase-1 activation in THP-1 cells [0.03%]
心房利钠肽通过抑制NF-κB，NLRP3炎性小体和半胱天冬酶-1活化下调LPS/ATP介导的THP-1细胞IL-1β释放
Letizia Mezzasoma,Cinzia Antognelli,Vincenzo Nicola Talesa
Letizia Mezzasoma
Atrial natriuretic peptide (ANP) is an hormone/paracrine/autocrine factor regulating cardiovascular homeostasis by guanylyl cyclase natriuretic peptide receptor (NPR-1). ANP plays an important role also in regulating inflammatory and immune...
Increased expression of long noncoding RNAs LOC100652951 and LOC100506036 in T cells from patients with rheumatoid arthritis facilitates the inflammatory responses [0.03%]
类风湿关节炎患者T细胞中长链非编码RNA LOC100652951和LOC100506036的高表达促进炎症反应
Ming-Chi Lu,Hui-Chun Yu,Chia-Li Yu et al.
Ming-Chi Lu et al.
The aim of this study was to evaluate whether the presence of aberrantly expressed lncRNAs could promote T cell inflammatory responses in patients with RA. The expression levels of 10 potential aberrantly expressed lncRNAs were evaluated in...
Murine macrophage response from peritoneal cavity requires signals mediated by chemokine receptor CCR-2 during Staphylococcus aureus infection [0.03%]
小鼠腹腔巨噬细胞对金黄色葡萄球菌感染的响应需要由化学引诱素受体CCR-2介导的信号通路
Ajeya Nandi,Biswadev Bishayi
Ajeya Nandi
C-C chemokine receptor-2 (CCR-2) is a cognate receptor for monocyte chemotactic protein-1 (MCP-1), and recent studies revealed that MCP-1-CCR-2 signaling is involved in several inflammatory diseases characterized by macrophage infiltration....
Construction of recombinant Mip-FlaA dominant epitope vaccine against Legionella pneumophila and evaluation of the immunogenicity and protective immunity [0.03%]
军团菌肺炎双球菌Mip-FlaA优势表位重组疫苗的构建及免疫效果评价
Jinlei He,Junrong Zhang,Yanxia He et al.
Jinlei He et al.
Legionnaires' disease, a kind of systemic disease with pneumonia as the main manifestation, is caused by Legionella pneumophila (L. pneumophila). In order to prevent the disease, we optimized Mip and FlaA, the virulence factors of L. pneumo...
Tumor MICA status predicts the efficacy of immunotherapy with cytokine-induced killer cells for patients with gastric cancer [0.03%]
肿瘤MICA状态预测细胞因子诱导的杀伤细胞免疫治疗胃癌患者的疗效
Yu Chen,Wan-Song Lin,Wei-Feng Zhu et al.
Yu Chen et al.
In this study, we determine the relationship between the expression of major histocompatibility complex class I chain-related gene A (MICA) in gastric cancer tumors after D2 gastrectomy and the clinical outcome of a CIK-containing adjuvant ...
Role of immune tolerance in BALB/c mice with anaphylactic shock after Echinococcus granulosus infection [0.03%]
免疫耐受在细粒棘球蚴感染后BALB/c小鼠过敏性休克中的作用研究
Qin Zhang,Jian-Rong Ye,Hai-Mei Ma et al.
Qin Zhang et al.
This study tested the hypothesis that immune tolerance mediated by regulatory T (Treg) cells is protective against cystic echinococcosis (CE)-induced anaphylactic shock. BALB/c mice were inoculated with protoscoleces of Echinococcus granulo...
Positive association of genetic variations in the phospholipase C-like 1 gene with dermatomyositis in Chinese Han [0.03%]
中国汉族人群中磷脂酶C样1基因多态性与皮肌炎的正相关研究
Qian Wang,Si Chen,Yuan Li et al.
Qian Wang et al.
Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases with an underlying yet undefined genetic component. Recently, phospholipase C-like 1 (PLCL1) has been identified as a potential genetic susceptibility locus for dermatomyosit...