Syed Makhdoom Hussain,Aqsa Sharif,Fatima Bashir et al.
Syed Makhdoom Hussain et al.
Polymerase chain reaction (PCR), a revolutionary molecular tool, has transformed genetic studies by facilitating rapid DNA amplification. The PCR process relies on several key components: a DNA template or cDNA, two primers, Taq polymerase,...
Downregulation of AQP9 Ameliorates NLRP3 Inflammasome-Dependent Inflammation and Pyroptosis in Crohn's Disease by Inhibiting the p38 MAPK Signaling Pathway [0.03%]
AQP9下调通过抑制p38MAPK信号通路缓解克罗恩病中NLRP3炎性小体依赖的炎症和细胞焦亡
Qin-Qin Zhu,Yin Zhang,Lu Cui et al.
Qin-Qin Zhu et al.
Crohn's disease (CD), a complex gastrointestinal disorder, can be attributed to a combination of genetic factors, immune system dysfunction, and environmental triggers. Aquaporin 9 (AQP9) has been implicated in immunoregulation and inflamma...
Sodium Alginate Attenuates H2O2-Induced Myocardial DNA Damage via VSNL1 Regulating the CNP/NPR-B Signaling Pathway [0.03%]
海藻酸钠通过VSNL1调节CNP/NPR-B信号通路缓解H2O2诱导的心肌DNA损伤
Rui Chang,Wenjuan Fang,Xing Yang et al.
Rui Chang et al.
Myocardial DNA damage plays a critical role in the pathogenesis of cardiovascular diseases, frequently leading to adverse outcomes such as myocardial infarction and heart failure. This study elucidated the protective effects of sodium algin...
Unraveling the Rhubarb (Rheum officinale Baill.) Root and Rhizosphere Microbial Communities in Response to Pathogen Exposure [0.03%]
病原菌胁迫下黄药 thua 根系及其根围微生物响应机制研究
Ruiting Xu,Wenxi Chen,Sihui Chen et al.
Ruiting Xu et al.
This study investigated the microbial community composition and structure in healthy and diseased rhubarb (Rheum rhabarbarum) root systems, examining both root tissue and rhizosphere environments. Alpha diversity analysis revealed significa...
NRF1 Transcriptionally Regulates USP1-Mediated Deubiquitination of AURKA to Facilitate Osteosarcoma Progression [0.03%]
NRF1通过转录调控USP1介导的AURKA去泛素化促进成骨细胞瘤进展
Yi-Bo Hui,Guan-Ning Shang
Yi-Bo Hui
The poor prognosis of osteosarcoma (OS) lead to the low survival rate of OS patients. Numerous researches have shown that nuclear factor erythroid 2-like 1 (NRF1) can regulate the development and progression of cancer, but it has not yet be...
Decoding the Chloroplast Genome of Korean endemic plant Acer okamotoanum: Comparative Genomics, Phylogenetic Insights, and Potential for Marker Development [0.03%]
decode Acer okamotoanum（ Acer ）的叶绿体基因组：比较基因组，系统发育见解和潜在标记开发
Suhas K Kadam,Asif S Tamboli,Jin-Suk Youn et al.
Suhas K Kadam et al.
Acer okamotoanum, a medicinally significant endemic plant of Korea, has seen limited genomic research. To address this gap, we conducted a comprehensive sequencing and analysis of its chloroplast genome. The assembled genome is 156,242 bp i...
Tissue-Specific Diversity of Nuclear-Encoded Mitochondrial Genes Related to Lipid and Carbohydrate Metabolism in Buffalo [0.03%]
与脂质和碳水化合物代谢相关的核编码线粒体基因的组织特异性多样性研究（水 buffalo）
E M Sadeesh,Madhuri S Lahamge,Sweta Kumari et al.
E M Sadeesh et al.
Buffaloes play a crucial role in Asian agriculture, enhancing food security and rural development. Their distinct metabolic needs drive tissue-specific mitochondrial adaptations, regulated by both mitochondrial and nuclear genomes. This stu...
Appraisal of CRISPR Technology as an Innovative Screening to Therapeutic Toolkit for Genetic Disorders [0.03%]
评估CRISPR技术作为遗传性疾病筛查和治疗工具箱的创新方法
Ayesha Shahid,Ambreen Zahra,Sabin Aslam et al.
Ayesha Shahid et al.
The high frequency of genetic diseases compels the development of refined diagnostic and therapeutic systems. CRISPR is a precise genome editing tool that offers detection of genetic mutation with high sensitivity, specificity and flexibili...
Study of Pineapple Bioactive Compounds Targeting Aldose Reductase: A Natural Intervention for Diabetes Mellitus Pathologies [0.03%]
靶向山梨醇脱氢酶的菠萝生物活性化合物研究：糖尿病自然干预措施的研究
Anand Kumar Pandey,Shalja Verma,Rupanjali Singh
Anand Kumar Pandey
Aldose reductase is a reduced monomeric enzyme that utilizes NADPH as a cofactor to mediate the glucose reduction to sorbitol in the polyol pathway. Overexpression of aldose reductase has been observed to mediate pathologies associated with...
Identification of Prognosis Signature Based on cGAS-STING Pathway and Its Immunotherapeutic Significance in Lung Adenocarcinoma [0.03%]
基于cGAS-STING通路的肺腺癌预后标志物鉴定及其免疫治疗意义
Xiao Huang,Xuefeng Lv,Xinghua Cao
Xiao Huang
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related deaths worldwide, and there is an urgent need to develop personalized prognostic models for effective treatment strategies. The cyclic GMP-AMP synthase (cGAS)-stimulator of int...