A Dual Perspective on Physio-molecular Insights Points Towards Ion Homeostasis as a Probable Pathway for Salt Tolerance in Pigeonpea [Cajanus Cajan (Millspaugh (L.)] [0.03%]
生理分子视角下的双重研究暗示离子稳态可能是 pigeonpea(Cajanus cajan)抗盐的途径
Rekha Joshi,Rishu Jain,Kishor U Tribhuvan et al.
Rekha Joshi et al.
Salt stress is a major abiotic factor limiting crop productivity and sustainable agriculture globally. It disrupts ionic balance and induces oxidative stress through excessive Na⁺ and Cl⁻ accumulation, leading to programmed cell death. We...
ACSM5 c.1273 C> A Polymorphism Promotes Malignant Progression of Lung Adenocarcinoma in Xuanwei Region [0.03%]
ACSM5 c.1273 C>A多态性促进宣威地区肺腺癌恶性进展
Chenglu He,Hui Zhang,Xiao Wang et al.
Chenglu He et al.
Lung adenocarcinoma (LUAD) is highly prevalent in Xuanwei region, Yunnan, China, but little is known about the genetic basis of this regional cancer. In our study, by performing the transcriptome sequencing and exome sequencing of Xuanwei L...
Exosomal FOSL1 From Cancer-associated Fibroblasts Drives the Progression and Pro-tumorigenic M2 Macrophage Polarization of Hepatocellular Carcinoma By Activating PLAU Transcription [0.03%]
癌相关成纤维细胞源外泌体FOSL1通过激活PLAU转录促进肝癌进展及M2型促肿瘤巨噬细胞极化
Kai Bai,Ruopeng Liang,Jian Li et al.
Kai Bai et al.
Exosomes derived from cancer-associated fibroblasts (CAFs) play a crucial role in cancer development. Fos-like antigen 1 (FOSL1) exhibits oncogenic properties across various malignancies. However, the specific role of FOSL1 in CAFs-derived ...
Thermophilic Biohydrogen Production Utilizing Green-Synthesized Hydroxyapatite (HAP): Insights into Substrate Optimization and Biogranule Formation [0.03%]
利用绿色合成羟基磷灰石(HAP)进行嗜热生物制氢：关于底物优化和生物粒径形成的见解
Shishita Zahan Zisha,Hasfalina Che Man,Rozita Omar et al.
Shishita Zahan Zisha et al.
This study presents an integrated approach for enhancing thermophilic biohydrogen production from palm oil mill effluent (POME) using eco-friendly hydroxyapatite (HAP) synthesized from waste eggshells. The synthesized HAP was applied as a b...
Transformation of Starch into an Equilibrium Pool of Glucose and Small Maltosaccharides by a Hyperthermophilic Enzyme Exhibiting Coupled (Exo)Amylase-Glucanotransferase Functions [0.03%]
一种能够耦联（外切）淀粉酶-葡聚糖转移酶功能的超嗜热酶将淀粉转化为葡萄糖和低麦芽糊精平衡池
Arpita Sarkar,Pallavi Kaila,Prince Tiwari et al.
Arpita Sarkar et al.
The hyperthermophilic enzyme, PfuAmyGT (PF0272), is a 656 residues-long, homodimeric GH57 glycoside hydrolase from Pyrococcus furiosus. It is a homolog of TLGT, an enzyme of known structure from Thermococcus litoralis, which is thought to c...
Immobilized Ancient Lipase for Waste-to-Fuel Biocatalysis: Toward Sustainable Biodiesel Production [0.03%]
固定化古脂酶用于废转能源生物催化：迈向可持续的生物柴油生产
Afifah Husna Mat Saad,Nor Hafizah Ahmad Kamarudin,Adam Thean Chor Leow et al.
Afifah Husna Mat Saad et al.
Developing thermally stable, reusable enzymes is key to eco-friendly biodiesel production. Here, we report the first immobilization of a sequence-reconstructed ancestral lipase from family 1.3 lipase, last universal common ancestor (LUCA) o...
Acacetin Alleviates Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease in Mice by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis [0.03%]
刺槐素通过抑制NLRP3炎性小体介导的细胞焦亡治疗小鼠慢性阻塞性肺疾病
Xuemin Xu,Xiaoming Liu,Li Yao et al.
Xuemin Xu et al.
Acacetin, a flavonoid, exhibits potent anti-inflammatory activity. However, its therapeutic potential against cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) remains unclear. Therefore, we aimed to investigate the ...
Correction to: Genetic Engineering of Escherichia coli W for Linalool Production Using Beet Juice as the Sole Carbon Source [0.03%]
Correction to: 以甜菜汁为单一碳源生产香茅醇的大肠杆菌W菌株的遗传工程改造
Matthew McKillop,Taufiq Nawaz,Liping Gu et al.
Matthew McKillop et al.
Published Erratum
Applied biochemistry and biotechnology. 2025 Nov 18. DOI:10.1007/s12010-025-05480-1 2025
DNA Methylation Patterns of 5mC Regulators: Insights into Immune Microenvironment Regulation in Heart Failure [0.03%]
心脏 failure中与免疫微环境调节相关的表观遗传调控机制研究
Zirui Liu,Meili Liu,Ying Xu et al.
Zirui Liu et al.
The 5-methylcytosine (5mC) epigenetic modification is a prominent pattern of DNA methylation. Nonetheless, its function and relationship with the immune microenvironment (IME) in heart failure (HF) are unclarified. Firstly, seven microarray...
Integrative Strategies to Enhance Enzyme-Protein Interactions for Drug Discovery and Biocatalysis [0.03%]
用于药物发现和生物催化的增强酶-蛋白质相互作用的集成策略
R Satheeskumar,V Premalatha,M Navaneetha Krishnan et al.
R Satheeskumar et al.
Enzyme-protein interactions (EPIs) are critical targets in both pharmaceutical development and industrial biocatalysis, but their effective modulation has been challenged by high false-positive rates (20-30%) in conventional screening metho...