Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer [0.03%]
功能蛋白质组学可以定义乳腺癌患者的预后并预测病理完全缓解
Ana M Gonzalez-Angulo,Bryan T Hennessy,Funda Meric-Bernstam et al.
Ana M Gonzalez-Angulo et al.
Purpose: To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and anthracycline...
Spectral counting assessment of protein dynamic range in cerebrospinal fluid following depletion with plasma-designed immunoaffinity columns [0.03%]
基于血液设计的免疫亲和柱清除血浆蛋白后脑脊液蛋白质动态范围的谱峰计数评估
Jacques Borg,Alex Campos,Claudio Diema et al.
Jacques Borg et al.
Background: In cerebrospinal fluid (CSF), which is a rich source of biomarkers for neurological diseases, identification of biomarkers requires methods that allow reproducible detection of low abundance proteins. It is th...
Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions [0.03%]
乳腺癌患者中与激肽释放酶相关的半胱氨酸蛋白酶5(KLK5)表达下调：鉴别诊断乳腺肿瘤的生物标志物
Margaritis Avgeris,Georgia Papachristopoulou,Athanasios Polychronis et al.
Margaritis Avgeris et al.
Background: Kallikrein-related peptidase 5 (KLK5) is a secreted trypsin-like protease of the KLK family, encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components, as well as to activ...
Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病抗代谢物治疗中实施个体化医学的挑战
Jacob Nersting,Louise Borst,Kjeld Schmiegelow
Jacob Nersting
Predicting the response to medical therapy and subsequently individualizing the treatment to increase efficacy or reduce toxicity has been a longstanding clinical goal. Not least within oncology, where many patients fail to be cured, and ot...
Danni L Meany,Daniel W Chan
Danni L Meany
Background: One of the new roles for enzymes in personalized medicine builds on a rational approach to cancer biomarker discovery using enzyme-associated aberrant glycosylation. A hallmark of cancer, aberrant glycosylatio...
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? [0.03%]
ADAM蛋白酶家族：癌症新的生物标志物和治疗靶点？
Michael J Duffy,Maeve Mullooly,Norma O&#x;Donovan et al.
Michael J Duffy et al.
The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their main substrates are the ectodo...
Daniel W Chan
Daniel W Chan
Two-dimensional difference gel electrophoresis (DIGE) analysis of sera from visceral leishmaniasis patients [0.03%]
利什曼病患者血清的二维差异凝胶电泳(DIGE)分析
Lokesh A Rukmangadachar,Jitender Kataria,Gururao Hariprasad et al.
Lokesh A Rukmangadachar et al.
Introduction: Visceral leishmaniasis is a parasitic infection caused by Lesihmania donovani complex and transmitted by the bite of the phlebotomine sand fly. It is an endemic disease in many developing countries with more...
Proteomic profiling of the mesenteric lymph after hemorrhagic shock: Differential gel electrophoresis and mass spectrometry analysis [0.03%]
出血性休克后肠系膜淋巴液蛋白质组变化的差异凝胶电泳及质谱分析
Ashley Zurawel,Ernest E Moore,Erik D Peltz et al.
Ashley Zurawel et al.
Experiments show that upon traumatic injury the composition of mesenteric lymph changes such that it initiates an immune response that can ultimately result in multiple organ dysfunction syndrome (MODS). To identify candidate protein mediat...
Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis [0.03%]
应用二维电泳技术分析芥子气致肺损伤患者血浆蛋白质指纹图谱
Hossein Mehrani,Mostafa Ghanei,Jafar Aslani et al.
Hossein Mehrani et al.
Introduction: Sulfur mustard "bis (2-chlroethyl) sulphide" (SM) is a chemical warfare agent that remains a threat to human health. The aim of this study was to identify protein expression signature or biomarkers that refl...