Ovarian cyst fluid is a rich proteome resource for detection of new tumor biomarkers [0.03%]
卵巢囊肿液是一种丰富的蛋白质资源，可用于检测新的肿瘤生物标志物
Björg Kristjansdottir,Karolina Partheen,Eric T Fung et al.
Björg Kristjansdottir et al.
Background: We aimed to investigate the use of ovarian cyst fluid as a source for biomarker discovery and to find novel biomarkers for use in the diagnosis of epithelial ovarian tumors. ...
Urine proteome of autosomal dominant polycystic kidney disease patients [0.03%]
常染色体显性多囊肾病患者的尿蛋白组学研究
Magda Bakun,Mariusz Niemczyk,Dominik Domanski et al.
Magda Bakun et al.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is responsible for 10% of cases of the end stage renal disease. Early diagnosis, especially of potential fast progressors would be of benefit for efficient ...
Quantitative proteomics for identifying biomarkers for tuberculous meningitis [0.03%]
定量蛋白质组学在结核性脑膜炎生物标志物筛选中的应用研究
Ghantasala S Sameer Kumar,Abhilash K Venugopal,Anita Mahadevan et al.
Ghantasala S Sameer Kumar et al.
Introduction: Tuberculous meningitis is a frequent extrapulmonary disease caused by Mycobacterium tuberculosis and is associated with high mortality rates and severe neurological sequelae. In an earlier study employing DN...
Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients [0.03%]
HIV-1和HCV单发和共感染患者单核细胞内的独特及差异蛋白质标志物谱型分析
Nawal M Boukli,Vivekananda Shetty,Luis Cubano et al.
Nawal M Boukli et al.
Background: Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophy...
Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue [0.03%]
基于激光分离固定标本的胰腺导管癌蛋白组学分析发现Nm23/nucleoside diphosphate kinase-A是潜在的预后标记物
Tatsuyuki Takadate,Tohru Onogawa,Kiyonaga Fujii et al.
Tatsuyuki Takadate et al.
Background: Pancreatic cancer is among the most lethal malignancies worldwide. This study aimed to identify a novel prognostic biomarker, facilitating treatment selection, using mass spectrometry (MS)-based proteomic anal...
Investigation of ovarian cancer associated sialylation changes in N-linked glycopeptides by quantitative proteomics [0.03%]
定量蛋白质组学研究卵巢癌相关N连接糖肽岩藻糖基化变化
Vivekananda Shetty,Julie Hafner,Punit Shah et al.
Vivekananda Shetty et al.
Background: In approximately 80% of patients, ovarian cancer is diagnosed when the patient is already in the advanced stages of the disease. CA125 is currently used as the marker for ovarian cancer; however, it lacks spec...
Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS) [0.03%]
采用选择反应监测质谱法（SRM-MS）开发多发性硬化症脑脊液蛋白生物标志物
Yan Jia,Tianxia Wu,Christine A Jelinek et al.
Yan Jia et al.
Background: Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS). It involves damage to the myelin sheath surrounding axons and to the axons themselves. MS most often presents wit...
Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer [0.03%]
乳腺癌中核糖体结合蛋白1(RRBP1)的过表达
Deepthi Telikicherla,Arivusudar Marimuthu,Manoj Kumar Kashyap et al.
Deepthi Telikicherla et al.
The molecular events that lead to malignant transformation and subsequent metastasis of breast carcinoma include alterations in the cells at genome, transcriptome and proteome levels. In this study, we used publicly available gene expressio...
The human proteome - a scientific opportunity for transforming diagnostics, therapeutics, and healthcare [0.03%]
人类蛋白质组学——改变诊断、治疗和医疗保健的科学机遇
Marc Vidal,Daniel W Chan,Mark Gerstein et al.
Marc Vidal et al.
A National Institutes of Health (NIH) workshop was convened in Bethesda, MD on September 26-27, 2011, with representative scientific leaders in the field of proteomics and its applications to clinical settings. The main purpose of this work...
Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue [0.03%]
甲醛固定肿瘤组织表皮生长因子受体（EGFR）的选定反应监测（SRM）分析
Todd Hembrough,Sheeno Thyparambil,Wei-Li Liao et al.
Todd Hembrough et al.
Background: Analysis of key therapeutic targets such as epidermal growth factor receptor (EGFR) in clinical tissue samples is typically done by immunohistochemistry (IHC) and is only subjectively quantitative through a na...