Detection of BK virus in urine from renal transplant subjects by mass spectrometry [0.03%]
移植受者尿液中BK病毒的质谱检测
Rebecca Konietzny,Roman Fischer,Nicola Ternette et al.
Rebecca Konietzny et al.
Background: The diagnosis and management of BK virus (BKV) reactivation following renal transplantation continues to be a significant clinical problem. Following reactivation of latent virus, impaired cellular immunity en...
The cerebrospinal fluid proteome in HIV infection: change associated with disease severity [0.03%]
HIV感染下的脑脊液蛋白质组变化与病情严重程度相关
Thomas E Angel,Jon M Jacobs,Serena S Spudich et al.
Thomas E Angel et al.
Background: Central nervous system (CNS) infection is a nearly universal feature of untreated systemic HIV infection with a clinical spectrum that ranges from chronic asymptomatic infection to severe cognitive and motor d...
Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry [0.03%]
利用质谱技术对前列腺炎患者精浆蛋白组的表征研究
Daniel Kagedan,Irene Lecker,Ihor Batruch et al.
Daniel Kagedan et al.
Background: Prostatitis is an inflammation of the prostate gland which affects approximately 10% of men. Despite its frequency, diagnosing prostatitis and monitoring patient response to treatment remains frustrating. As t...
Virtual screening and evaluation of Ketol-Acid Reducto-Isomerase (KARI) as a putative drug target for Aspergillosis [0.03%]
虚拟筛选和评估酮酸还原异构酶(KARI)作为曲霉病药物靶点的可能性
Vivek K Morya,Shalini Kumari,Eun-Ki Kim
Vivek K Morya
Aspergillus is a leading causative agent for fungal morbidity and mortality in immuno-compromised patients. To identify a putative target to design or identify new antifungal drug, against Aspergillus is required. In our previous work, we h...
Desmin expression in colorectal cancer stroma correlates with advanced stage disease and marks angiogenic microvessels [0.03%]
肌球蛋白在结直肠癌间质中的表达与晚期疾病及血管生成性微血管标志有关
Georgia Arentz,Tim Chataway,Timothy J Price et al.
Georgia Arentz et al.
Introduction: Biomarkers that improve stratification of colorectal cancer patients for adjuvant therapy versus resection alone, or that are predictive of response to therapeutic agents, have the potential to greatly impro...
Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4 [0.03%]
糖尿病肾脏形态变化与细胞骨架蛋白包括α-肌聚糖O-GlcNAc酰化增加有关
Yoshihiro Akimoto,Yuri Miura,Tosifusa Toda et al.
Yoshihiro Akimoto et al.
Purpose: The objective of the present study is to identify proteins that change in the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from diabetic model Goto-Kakizaki (GK) ra...
A simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studies [0.03%]
一种更简单的MALDI-TOF MS数据预处理方法用于差异生物标志物分析：干细胞和黑色素瘤癌症研究
Dong L Tong,David J Boocock,Clare Coveney et al.
Dong L Tong et al.
Introduction: Raw spectral data from matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) with MS profiling techniques usually contains complex information not readily providing biological insight into d...
Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery [0.03%]
评价一种新型的口腔病变渗出物收集方法与基于质谱的蛋白质组学相结合发现口腔癌生物标志物的潜力
Joel A Kooren,Nelson L Rhodus,Chuanning Tang et al.
Joel A Kooren et al.
Introduction: Early diagnosis of Oral Squamous Cell Carcinoma (OSCC) increases the survival rate of oral cancer. For early diagnosis, molecular biomarkers contained in samples collected non-invasively and directly from at...
Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance [0.03%]
临床药物药理基因组学相关的药物代谢酶活性与遗传变异之间的关系
Alan Hb Wu
Alan Hb Wu
Enzymes are critically important in the transportation, metabolism, and clearance of most therapeutic drugs used in clinical practice today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme's rate kinetics...
Immobilized pH gradient-driven paper-based IEF: a new method for fractionating complex peptide mixtures before MS analysis [0.03%]
基于IEF的纸基pH梯度固相 immobilization：一种用于质谱分析前复杂肽混合物分离的新方法
Beerelli Seshi,Kumaraguru Raja,Kh Chandramouli
Beerelli Seshi
Introduction: The vast difference in the abundance of different proteins in biological samples limits the determination of the complete proteome of a cell type, requiring fractionation of proteins and peptides before MS a...