Guido Valesini,Fabrizio Conti
Guido Valesini
Systemic lupus erythematosus has long been considered the prototypic autoimmune disease. Although the etiology remains enigmatic, there has been vigorous definition of the clinical features and the natural history. In this issue, we review ...
Reproductive immunology: a focus on the role of female sex hormones and other gender-related factors [0.03%]
生殖免疫学：侧重于女性性激素及其他性别相关因素的作用
Elena Peeva
Elena Peeva
Reproductive immunology has attracted the attention of researchers interested in fertility and pregnancy as well as those interested in immunity and autoimmunity. Over the past couple of decades, a wealth of data on the immune-reproductive ...
Fabrizio Conti,Francesca Romana Spinelli,Cristiano Alessandri et al.
Fabrizio Conti et al.
A variety of immune mechanisms, both humoral and cellular, are involved in the onset and amplification of the inflammatory response in lupus nephritis (LN). Accumulating evidence substantiates the view that innate immunity pathways may also...
Robert A Nathan
Robert A Nathan
While nasal congestion has been identified as one of the most bothersome and prevalent symptoms of allergic rhinitis, it is underappreciated that many patients find rhinorrhea also to be bothersome. Rhinorrhea as a symptom of allergic rhini...
Konstantinos Giannakakis,Tullio Faraggiana
Konstantinos Giannakakis
The spectrum of morphologic changes in lupus nephritis, either microscopic, ultrastructural, or immunohistological, closely reflects the great variety of immune complexes that are produced in the course of the disease. Every tissue componen...
Manuel Ramos-Casals,Candido Diaz-Lagares,Maria-Jose Soto-Cardenas et al.
Manuel Ramos-Casals et al.
The complexity of the therapeutic approach in lupus nephritis (LN) is increased by the large number of patients who do not respond to first-line therapies and by relapses after initial clinical remission. The emergence of biological agents ...
Catherine Hanrotel-Saliou,Isabelle Segalen,Yannick Le Meur et al.
Catherine Hanrotel-Saliou et al.
Lupus nephritis (LN) remains the most common severe manifestation of systemic lupus erythematosus (SLE) characterized by the presence of autoantibodies (Abs) that are believed to play a central role in the pathogenesis of LN. Among more tha...
Chemokines and their receptors in the allergic airway inflammatory process [0.03%]
趋化因子及其受体在过敏性气道炎症过程中的作用
Juan Raymundo Velazquez,Luis Manuel Teran
Juan Raymundo Velazquez
The development of the allergic airway disease conveys several cell types, such as T-cells, eosinophils, mast cells, and dendritic cells, which act in a special and temporal synchronization. Cellular mobilization and its complex interaction...
Melissa Cunningham,Gary Gilkeson
Melissa Cunningham
Due to the female predominance of autoimmune diseases, the role of gender and sex hormones in the immune system is of long-term interest. Estrogen's primary effects are mediated via estrogen receptors alpha and beta (ER α/β) that are expr...