Differentiating Acute-onset Autoimmune Hepatitis From Drug-Induced Autoimmune-like Hepatitis: A Multicenter Study and Score Development [0.03%]
急性自身免疫性肝炎与药物诱导的类似自身免疫性肝损伤的鉴别诊断：多中心研究及评分系统构建
Haoyu Wen,Yu Chen,Qiuxiang Lin et al.
Haoyu Wen et al.
The incidence of acute-onset autoimmune hepatitis (A-AIH) is increasing, yet diagnosis remains challenging, especially in patients with recent hepatotoxic drug exposure. The clinical presentations of A-AIH and drug-induced autoimmune-like h...
Mapping Neuro Behcet's Disease Across North Africa: a Systematic Review and Meta Analysis [0.03%]
北非神经Behçet病的系统评价和meta分析地图集
Nabil Belfeki,Nouha Ghriss,Monia Smiti et al.
Nabil Belfeki et al.
Data on neuro-Behçet's disease in North Africa remain limited and fragmented. We conducted a systematic review and meta-analysis to estimate the frequency of neurologic involvement in North African patients with Behçet's disease and to su...
Early-life Gut Microbiota and Allergic Diseases: Immune Regulatory Mechanisms and Intervention Progress [0.03%]
生命早期肠道微生物与过敏性疾病：免疫调节机制及干预进展
Lei Yu,Maolan Wu,Tingfan Leung et al.
Lei Yu et al.
Over recent decades, the prevalence of allergic diseases has risen steadily, particularly among children, making these conditions a major global public health concern. Increasing evidence suggests that, in addition to genetic factors, gut m...
Xiang Piao,Yingqi Hang,Li Bai et al.
Xiang Piao et al.
Obesity-related asthma is a major clinical challenge defined by its unique pathology and resistance to corticosteroids. Here, we reframe this disease through the lens of tissue-specific "maladaptive plasticity" of group 2 innate lymphoid ce...
Immunopathogenesis and Experimental Models of Alopecia Areata: From Mechanistic Insights to Translational Platforms [0.03%]
免疫病理和斑秃实验模型：从机制见解到转化平台
Ying Wang,Yichuan Li,Yinyi Feng et al.
Ying Wang et al.
Alopecia areata (AA) is a common autoimmune, non-scarring hair loss disorder with substantial clinical heterogeneity and psychosocial burden. Although recent therapeutic advances, particularly Janus kinase (JAK) inhibitors, have transformed...
Tryptophan Metabolism at the Crossroads of Immunity, Barrier Function, and the Microbiome in Atopic Dermatitis [0.03%]
特应性皮炎中色氨酸代谢在免疫、屏障功能和微生物组的交汇点上的作用
Yi Tan,Ge Peng,Alafate Abudouwanli et al.
Yi Tan et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by complex interplay among immune imbalance, impaired barrier function, and alterations in host‒microbiome interactions. Accumulating evidence indicates that trypt...
Dendritic cells as orchestrators in the allergen-specific immunotherapy of allergic diseases [0.03%]
特应性疾病过敏原免疫治疗中树突状细胞的协调作用
Xiyang Dou,Tian Gu,Yu Xu
Xiyang Dou
Dendritic cells (DCs) play a pivotal role in regulating immune responses, encompassing both tolerance and activation. Dysregulation of DC function is fundamental in the development of allergic conditions, underscoring their significance as ...
Pragmatic Strategies for Reducing Variability and Risk in Food Oral Immunotherapy [0.03%]
实用策略：减少食物口服免疫疗法的变异性与风险
Thomas B Casale,Cosby A Stone,Martin D Chapman et al.
Thomas B Casale et al.
Oral immunotherapy (OIT) can be effective and relatively safe for the treatment of food allergies, especially when started early in life. Grocery store foods used in OIT protocols are often heterogeneous in allergen potency and display prod...
T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives [0.03%]
系统性红斑狼疮中的T细胞免疫衰老：分子机制和治疗前景
Suqing Zhou,Lian Jian,Hui Chen et al.
Suqing Zhou et al.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by chronic immune activation, relapsing-remitting clinical progression, and progressive multi-organ damage. In addition to the classical characteristics ...
Vitiligo as a Failure of Immune Resolution and Tissue Regeneration: From Stress Signals to Targeted Immune Modulation [0.03%]
白癜风作为免疫反应失败和组织再生障碍的疾病：从压力信号到靶向免疫调节
Ana Vitória Pupo Silvestrini,Jackeline Marino Lucas,Cristina Ribeiro de Barros Cardoso et al.
Ana Vitória Pupo Silvestrini et al.
Traditionally, vitiligo is known as a cutaneous autoimmune disease characterized by progressive melanocyte loss. However, this paradigm alone does not fully explain disease chronicity, relapse, or the limited therapeutic responses. Evidence...