Atopic Comorbidities and Topical Steroids in Early Childhood Atopic Dermatitis: Are We Missing a Piece of the Puzzle? [0.03%]
婴儿期湿疹 topical皮质类固醇和atopic共病：我们遗漏了什么？
Courtney A Chau,Sonya L Cyr,Ruchi Gupta et al.
Courtney A Chau et al.
Model-Based Meta-Analysis of IL-17 A Inhibitors for Moderate-to-Severe Plaque Psoriasis: Establishing Exposure-Response Relationships to Inform Targeted Drug Development [0.03%]
基于模型的IL-17A抑制剂治疗斑块状银屑病中重度患者的Meta分析：建立暴露反应关系以指导靶向药物开发
Yixiao Liu,Xiaoya Chen,Ling Xu et al.
Yixiao Liu et al.
This study aimed to establish an exposure-response model for IL-17 A inhibitors to predict the clinical efficacy of novel agents based on in vitro potency and pharmacokinetic parameters, guiding the development of new IL-17 A-targeting ther...
Baseline Blood Eosinophil Count for Identifying Superior Responders to Biologics in Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Meta-Analysis [0.03%]
血嗜酸性粒细胞计数在鼻息肉型慢性鼻窦炎生物制剂疗效评估中的价值：系统评价和meta分析
Yang Zheng,Wei Liu,Yujuan Yang et al.
Yang Zheng et al.
Comparative Efficacy of Combined and Standalone Oral Immunotherapies for Peanut Allergy: a Bayesian Network Meta-Analysis of RCTs [0.03%]
基于随机对照试验的联合和单一口服免疫疗法治疗花生过敏有效性的网络 meta 分析：贝叶斯方法
Xinyu Tian,Shuang Liu,Lisha Li et al.
Xinyu Tian et al.
Background: Peanut allergy is a chronic IgE-mediated disease with potentially life-threatening consequences. While several immunotherapeutic strategies have emerged, including oral immunotherapy (OIT), omalizumab (OMA)-ba...
Immunopathogenesis and Therapeutics of Systemic Lupus Erythematosus: an Integrative Review [0.03%]
系统性红斑狼疮的免疫病理发病机制及治疗药物整合型综述研究
Qian Lyu,Huan Zou,Shen Hu
Qian Lyu
Systemic lupus erythematosus (SLE) is a chronic, heterogeneous autoimmune disease with a strong female predisposition, characterized by multi-organ inflammation and damage. Its pathogenesis arises from a complex interplay of genetic suscept...
Association between COVID-19 and New-Onset Autoimmune Diseases: Updated Systematic Review and Meta-Analysis of 97 Million Individuals [0.03%]
冠状动脉疾病新发自身免疫性疾病之间的联系：9700万人的系统回顾和meta分析更新
Chih-Chen Tzang,Henry Sheng,Vicky Fu-Hsuan Kuo et al.
Chih-Chen Tzang et al.
SARS-CoV-2 infection may induce long-term immune dysregulation; however, its contribution to the development of autoimmune disease remains disputed. We aim to quantify the relative risk of new-onset autoimmune diseases following COVID-19 an...
A Multisectoral Study of Mpox Epidemiology, Resistance Surveillance, and Policy Gaps: Toward a One Health Framework [0.03%]
MPX流行病学、耐药监测和政策差距的多部门研究：迈向“同一健康”框架
Durjoy Mistry,Mehjabin Hossain,B S Diba et al.
Durjoy Mistry et al.
Mpox, formerly known as monkeypox, has recently spread beyond its traditional epidemic areas. Several regions of Africa have been affected and have become a health concern globally. This review presents epidemiology, clinical symptoms, diag...
Potential Mechanisms and Hypotheses for Pathogenic Microorganisms Triggering Kawasaki Disease [0.03%]
致病微生物触发川崎病的潜在机制和假说
Jinhan Yu,Linlin Cheng,Haoting Zhan et al.
Jinhan Yu et al.
Kawasaki disease (KD) is an acute, self-limiting systemic vasculitis of early childhood and remains the leading cause of acquired heart disease in developed nations. Despite decades of investigation, its etiology and immunopathogenesis are ...
Immunological Mechanisms and Outcomes of T-cell-Targeted Immunotherapy in Food Allergy: A Systematic Review [0.03%]
针对食物过敏T细胞免疫疗法的免疫学机制和疗效：系统性综述
Svetlana Fesenko,Stella A Nicolaou
Svetlana Fesenko
Food allergy is an increasing public health concern characterized by inappropriate Th2-driven immune responses to otherwise harmless food antigens, leading to IgE-mediated hypersensitivity. Current management strategies rely on allergen avo...
Pathophysiologic Mechanisms and Targeted Treatments Associated with the Nervous System in Cutaneous Allergic Diseases [0.03%]
皮肤过敏性疾病相关神经系统的病理生理机制及靶向治疗
Hantian Zhang,Weiyi Xiang,Yi Tong et al.
Hantian Zhang et al.
The skin is a highly innervated and immunologically active barrier organ, where neuro-immune interactions critically shape both physiological homeostasis and disease progression. Growing evidence indicates that bidirectional crosstalk betwe...