Investigating Non-celiac Wheat Sensitivity: A Comprehensive Review of Pathophysiology Underlying Clinical Implications [0.03%]
非乳糜泻性小麦敏感症的病因及临床意义の病理生理机制探究综述
Anays Piotin,Frédéric de Blay
Anays Piotin
Non-celiac wheat sensitivity (NCWS) is a clinical entity characterized by gastrointestinal and extraintestinal symptoms triggered by wheat ingestion, distinct from celiac disease and wheat allergy. Its pathophysiology is complex and multifa...
Joyce Z X Lee,Jason K C Sit,Nicki Y H Leung et al.
Joyce Z X Lee et al.
Allergen-specific immunotherapy (AIT) is currently the only disease-modifying treatment for food allergies. The most extensively studied form of AIT is oral immunotherapy, in which an increasing dose of specific food allergen is gradually i...
Immunodeficiencies in Adults: Key Considerations for Diagnosis and Management [0.03%]
成人免疫缺陷的诊断与治疗要点
Jean Regina,Jacqueline Doms,Eleftheria Kampouri et al.
Jean Regina et al.
Immunodeficiencies in adults are increasingly recognized yet often remain underdiagnosed, leading to significant morbidity from recurrent infections, autoimmunity, and malignancy. Both primary immunodeficiencies (PIDs), now known as inborn ...
PD-1/PD-L1 Cancer Immunotherapeutics Reshape Tumor Microenvironment - Clinical Evidence and Molecular Mechanisms for AI-based Precision Medicine [0.03%]
PD-1/PD-L1癌症免疫治疗重塑肿瘤微环境：基于人工智能的精准医学临床证据和分子机制研究
Yen-Yi Lin,Jeak Ling Ding,Hsieh-Tsung Shen et al.
Yen-Yi Lin et al.
PD-1 (Programmed cell death protein 1) located on T cells, binds to PD-L1 (Programmed cell death ligand 1) on cancer cells, to suppress T cell activation and enable immune evasion. Hitherto, reviews have mainly highlighted the role of PD-1/...
Glandular Manifestations of the Head and Neck in ANCA-Associated Vasculitides: Data from a National Cohort and Systematic Review [0.03%]
抗中性粒细胞胞浆抗体相关血管炎头颈部腺体受累的临床表现：基于国家登记数据和系统评价的结果分析
Nicolas Duhamel,Xavier Puéchal,Thomas Le Gallou et al.
Nicolas Duhamel et al.
Glandular involvement of the head and neck is an extremely rare feature in ANCA-associated vasculitis (AAV). The objective was to describe glandular involvement in AAV by analysing data from a national cohort and comparing the findings to t...
Sakura Sato,Ken-Ichi Nagakura,Noriyuki Yanagida et al.
Sakura Sato et al.
Food allergies affect 6-8% of children worldwide and can significantly impact quality of life, with potentially severe reactions including anaphylaxis. Over recent decades, oral immunotherapy (OIT) has emerged as a treatment option for food...
Coexistence of VEXAS Syndrome and Chronic Hepatitis B Virus Infection: a Case Report and Literature Review [0.03%]
VEXAS综合征与慢性乙型肝炎病毒感染并存的病例报道及文献复习
Kailong Lin,Yanqing Wang,Jiamin Song et al.
Kailong Lin et al.
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently identified late-onset, X-linked autoinflammatory disorder caused by somatic mutations in the ubiquitin-like modifier activating enzyme 1 (UBA1) gene, wh...
Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies [0.03%]
慢性鼻窦炎和鼻息肉的致病机制及靶向IL-4/IL-13信号通路治疗反应的研究进展
Jiani Chen,Chen Zhang,Qianqian Zhang et al.
Jiani Chen et al.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 sign...
The Ubiquitin-Proteasome System in Asthma: Mechanisms and Therapeutic Possibilities [0.03%]
泛素-蛋白酶体系统在哮喘中的机制及治疗潜力
Shuangyu He,Siqi Wen,Zhen Wang et al.
Shuangyu He et al.
The ubiquitin-proteasome system (UPS) plays a crucial role in asthma by regulating protein stability And activity through post-translational modifications. This review provides a comprehensive Analysis of 42 UPS components in asthma, includ...
Decoding Allergic Conjunctivitis: Latest Perspectives on Etiological Drivers and Immunopathological Mechanisms [0.03%]
过敏性结膜炎病因驱动因素和免疫病理机制的最新研究进展
Jiayu Bao,Ya Wen,Lei Tian et al.
Jiayu Bao et al.
Allergic conjunctivitis (AC) is a common ophthalmic disease, ranging from mild, self-limiting forms to severe, vision-threatening conditions such as vernal keratoconjunctivitis and atopic keratoconjunctivitis. Its pathogenesis originates fr...