Utility of in Vivo and Ex-vivo Models in Food Allergy Research: Lessons for Shrimp Allergy [0.03%]
活体和体外模型在食品过敏研究中的作用——来自虾过敏的研究启示
Minh Kieu Le,Binh Vu Thanh Luong,Tuan Anh Tran et al.
Minh Kieu Le et al.
We are living in an era where food allergy is increasingly prevalent, and shrimp allergy (SA) is among the most common and potentially severe reactions worldwide. Significant efforts have been made to improve diagnostic accuracy and treatme...
Chimeric Antigen Receptor T Cell Therapy in Systemic Lupus Erythematosus: Mechanisms, Clinical Advances, and Future Directions a Comprehensive Review [0.03%]
嵌合抗原受体T细胞疗法治疗系统性红斑狼疮：机制、临床进展和未来方向（综合述评）
Ahmad Matarneh,Bayan Matarneh,Omar Salameh et al.
Ahmad Matarneh et al.
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disorder characterized by loss of self-tolerance, immune complex deposition, and progressive organ damage. Despite advances in immunosuppressive therapy, a subset of pa...
Microorganisms, Microbial Metabolites and Precision Nutrition: Targeting the Gut-Skin Axis for Immune Microenvironment Remodeling in Atopic Dermatitis [0.03%]
微生物、微生物代谢产物和精准营养：靶向皮肤过敏性疾病中肠-皮肤病轴以重塑免疫微环境
Sibo Liu,Qingxue Chen,Yue Gu et al.
Sibo Liu et al.
Atopic dermatitis (AD), characterized by skin barrier dysfunction and microbiota dysbiosis, is closely linked to immune microenvironment imbalance. Growing evidence highlights the crucial role of microorganisms and their metabolites in immu...
Michael Freeley
Michael Freeley
Chimeric Antigen Receptor (CAR) T cell therapy has revolutionised the treatment of relapsed/refractory B cell leukaemia, lymphoma and multiple myeloma through targeting of CD19 and BCMA antigens on the surface of these cells. A growing body...
Jiaxin Lei,Mengdi Liu,Xiao Huang et al.
Jiaxin Lei et al.
Self-DNA sensing by the immune system was discovered more than half a century ago. It has emerged as a key factor in the development of cancer, autoimmune diseases and many inflammatory diseases. While the innate immune response has been ex...
COVID-19-associated Autoimmune and Inflammatory Diseases: Molecular Mechanisms and the Role of IVIG Therapy [0.03%]
COVID-19相关自身免疫和炎症性疾病：分子机制及静脉注射免疫球蛋白治疗的作用
Sukanya Bordoloi,Suraj C Singh,Jagadeesh Bayry
Sukanya Bordoloi
The emergence of SARS-CoV-2 has not only reshaped our understanding of viral pathogenesis but also highlighted its capacity to trigger autoimmune and inflammatory diseases. Accumulating evidence indicates that SARS-CoV-2 infection can lead ...
Inflammation and Immune Pathways in Myopia: An Overview on Pathomechanisms and Treatment Prospects [0.03%]
关于近视炎症和免疫途径的概述：病理机制与治疗前景
Jing Zhang,Koju Kamoi,Yuan Zong et al.
Jing Zhang et al.
Myopia represents a growing global public health challenge, characterized by increasing prevalence and associated complications such as myopic macular degeneration and retinal detachment. Although genetic and environmental factors are well-...
Multi-target Effects of Short-Chain Fatty Acids for Obesity-Related Asthma: Interventional Potential and Challenges [0.03%]
肥胖相关哮喘的短链脂肪酸多靶效应：干预潜力与挑战
Mingxin Liang,Lan Li,Juan Fan
Mingxin Liang
In recent years, the prevalence of obesity and asthma has risen steadily, emerging as two major chronic diseases threatening public health. These conditions exert mutual promotion and may induce pathological superposition effects in obesity...
The Genomics/Genetics of Primary Biliary Cholangitis: The Case for a Functional SNP rs10893900 in ETS1/FLI1 and Review of the Literature [0.03%]
原发性胆汁性肝硬化基因组学/遗传学：ETS1/FLI1功能SNP位点rs10893900的病例以及文献综述
Mingming Zhang,Chan Wang,Yexi Huang et al.
Mingming Zhang et al.
ETS1 and FLI1 exhibit distinct roles in immunoregulation and autoimmune pathogenesis. Previous transethnic genome-wide meta-analyses incorporating our Han Chinese population established significant associations between ETS1 single-nucleotid...
The Pathogenic Role of T Cell Metabolism and its Effect on Immune Senescence in Autoimmune Diseases and Infection [0.03%]
T细胞代谢的致病作用及其对自身免疫疾病和感染状态下免疫衰老的影响研究
Huan Yin,Suqing Zhou,Kai Shen et al.
Huan Yin et al.
T cell metabolism constitutes a pivotal regulator of cellular states and disease progression. At the cellular level, the metabolic status of T cells directly governs their function and fate determination. Senescent T cells, for instance, ex...