Chronic Urticaria: Advances in Understanding of the Disease and Clinical Management [0.03%]
慢性荨麻疹：疾病认识和临床管理的进展
Liting He,Wanyu Yi,Xin Huang et al.
Liting He et al.
Chronic urticaria (CU) is a common skin condition characterized by the recurrence of wheals, with or without angioedema, which lasts for at least 6 weeks. Owing to its pruritus and incurability, this disease adversely affects the patients' ...
Ling-Jen Wang,Shu-Chi Mu,Ming-I Lin et al.
Ling-Jen Wang et al.
Food allergies (FAs) are an emerging health care issue, and a "second wave of the allergy epidemic" was named. There are extensive data that documented the prevalence rate as high as approximately 10%. FAs are immunological adverse reaction...
Systemic Lupus Erythematosus and Pregnancy: a Portuguese Case-Control Study [0.03%]
系统性红斑狼疮与妊娠：一项葡萄牙病例对照研究
António Braga,Tânia Barros,Raquel Faria et al.
António Braga et al.
Pregnancy in systemic lupus erythematosus (SLE) patients is associated with an increased risk of adverse outcomes. During pregnancy, SLE patients have a higher rate of miscarriage, stillbirth, preterm delivery, fetal growth restriction, or ...
Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings [0.03%]
风湿性关节炎中的自身抗体：历史背景和最新发现
Maria V Sokolova,Georg Schett,Ulrike Steffen
Maria V Sokolova
Autoantibodies represent a hallmark of rheumatoid arthritis (RA), with the rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) being the most acknowledged ones. RA patients who are positive for RF and/or ACPA ("serop...
Benedetta Terziroli Beretta-Piccoli,Giorgina Mieli-Vergani,Diego Vergani
Benedetta Terziroli Beretta-Piccoli
Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the d...
Marie Elise Truchetet,Nicolò C Brembilla,Carlo Chizzolini
Marie Elise Truchetet
From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical presentation and course are highly heterogenous and l...
Chao Ji,Haiqing Wang,Chengbei Bao et al.
Chao Ji et al.
Nail psoriasis is a refractory disease that affects 50-79% skin psoriasis patients and up to 80% of patients with psoriatic arthritis (PsA). The pathogenesis of nail psoriasis is still not fully illuminated, although some peculiar inflammat...
Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies [0.03%]
系统性硬化症的治疗途径：最近的批准和未来候选疗法
Alain Lescoat,David Roofeh,Masataka Kuwana et al.
Alain Lescoat et al.
Systemic sclerosis is the rheumatic disease with the highest individual mortality. The severity of the disease is determined by the extent of fibrotic changes to cutaneous and internal organ tissues, the most life-threatening visceral manif...
Serum ANCA as Disease Biomarkers: Clinical Implications Beyond Vasculitis [0.03%]
血清ANCA作为疾病生物标志物：超出血管炎的临床意义
Marco Folci,Giacomo Ramponi,Virginia Solitano et al.
Marco Folci et al.
Usually associated with autoimmune diseases, anti-neutrophil cytoplasmic antibodies are also detected in other conditions, such as infections, malignancies, and after intake of certain drugs. Even if the mechanisms of production and their p...
Nicole Akar-Ghibril
Nicole Akar-Ghibril
The innate immune system is the host's first line of defense against pathogens. Toll-like receptors (TLRs) are pattern recognition receptors that mediate recognition of pathogen-associated molecular patterns. TLRs also activate signaling tr...