Loveita S Raymond,Jennifer Leiding,Lisa R Forbes-Satter
Loveita S Raymond
As the field of inborn errors of immunity expands, providers continually update and fine-tune their diagnostic approach and selection of testing modalities to increase diagnostic accuracy. Here, we first describe a mechanistic consideration...
Dupilumab-Associated Adverse Events During Treatment of Allergic Diseases [0.03%]
dupilumab治疗过敏性疾病过程中的不良反应事件分析
Anna Kychygina,Myriam Cassagne,Marie Tauber et al.
Anna Kychygina et al.
Among the new biological therapies for atopic diseases, dupilumab is a fully human monoclonal antibody directed against IL-4Rα, the common chain of interleukin-4 and interleukin-13 receptors. Dupilumab showed clinical improvements in patie...
The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease [0.03%]
气道微生物群-白细胞介素17轴：慢性炎症性疾病的关键调节因素
Jenny M Mannion,Rachel M McLoughlin,Stephen J Lalor
Jenny M Mannion
The respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is only beginning to be appreciated. Increasing reports have linked changes in this microbiome to a range of pulmonary and...
Clinical Significance of Antinucleolar Antibodies: Biomarkers for Autoimmune Diseases, Malignancies, and others [0.03%]
抗核仁抗体的临床意义：自身免疫性疾病、恶性肿瘤等疾病的生物标志物
Minoru Satoh,Angela Ceribelli,Tomoko Hasegawa et al.
Minoru Satoh et al.
Nucleolar staining is one of the standard patterns in immunofluorescence antinuclear antibodies (ANA), seen in 5-9% of ANA in various conditions. Antinucleolar antibodies (ANoA) are classified into 3 patterns in the International Consensus ...
Premedication Protocols to Prevent Hypersensitivity Reactions to Chemotherapy: a Literature Review [0.03%]
预防化疗引起的过敏反应的预处理方案——文献综述
Faisal ALMuhizi,Leticia De Las Vecillas Sanchez,Lucy Gilbert et al.
Faisal ALMuhizi et al.
Hypersensitivity reactions (HSRs) to chemotherapy may prevent patients from receiving the most effective therapy. This review was undertaken to identify evidence-based preventive premedication strategies that reduce the likelihood of HSR in...
A Narrative Review of Pathogenetic and Histopathologic Aspects, Epidemiology, Classification Systems, and Disease Outcome Measures in Systemic Sclerosis [0.03%]
系统性硬化症的病因和组织病理学、流行病学、分类系统及疾病转归指标述评
Maria-Grazia Lazzaroni,Silvia Piantoni,Fabrizio Angeli et al.
Maria-Grazia Lazzaroni et al.
Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by the presence of three main actors: vasculopathy, immune activation, and fibrosis. This pathologic process is then translated in a clinical picture with great v...
Cristiane Kayser,Lívia Almeida Dutra,Edgard Torres Dos Reis-Neto et al.
Cristiane Kayser et al.
Personalized medicine (PM) aims individualized approach to prevention, diagnosis, and treatment. Precision Medicine applies the paradigm of PM by defining groups of individuals with akin characteristics. Often the two terms have been used i...
Autoantibody Markers of Increased Risk of Malignancy in Patients with Dermatomyositis [0.03%]
皮肌炎患者恶性肿瘤危险度增加的自身抗体标志物研究
Milena Marzęcka,Anna Niemczyk,Lidia Rudnicka
Milena Marzęcka
Dermatomyositis is a chronic inflammatory disease involving the skin and muscles. It most commonly occurs in adults with preponderance in females, but pediatric occurrence is also possible. The risk of malignancy in adult patients with derm...
Spectrum of Genetic T-Cell Disorders from 22q11.2DS to CHARGE [0.03%]
从22q11.2染色体微缺失综合征到CHARGE综合症的遗传性T细胞紊乱谱系
Daniel Urschel,Vivian P Hernandez-Trujillo
Daniel Urschel
Improved genetic testing has led to recognition of a diverse group of disorders of inborn errors of immunity that present as primarily T-cell defects. These disorders present with variable degrees of immunodeficiency, autoimmunity, multiple...
The Role of Patch Testing in Evaluating Delayed Hypersensitivity Reactions to Medications [0.03%]
药疹延迟过敏反应的斑贴试验评估及其作用
Carina M Woodruff,Nina Botto
Carina M Woodruff
Confirming drug imputability is an important step in the management of cutaneous adverse drug reactions (CADR). Re-challenge is inconvenient and in many cases life threatening. We review the literature on ideal patch testing technique for s...