Autoinflammatory Keratinization Diseases-The Concept, Pathophysiology, and Clinical Implications [0.03%]
自身炎症性角化病的概念、病理生理及临床意义
Leszek Blicharz,Joanna Czuwara,Lidia Rudnicka et al.
Leszek Blicharz et al.
Recent advances in medical genetics elucidated the background of diseases characterized by superficial dermal and epidermal inflammation with resultant aberrant keratosis. This led to introducing the term autoinflammatory keratinization dis...
Michael R Goldberg,Naama Epstein-Rigbi,Arnon Elizur
Michael R Goldberg
Gastrointestinal adverse events are common during oral immunotherapy (OIT) for food allergy and range from immediate IgE-mediated reactions to non-anaphylactic clinical presentations. This review aims to summarize recent findings on non-ana...
A Retrospective Analysis of Long-Term Prophylaxis with Berotralstat in Patients with Hereditary Angioedema and Acquired C1-Inhibitor Deficiency-Real-World Data [0.03%]
补体抑制剂伯罗司他坦长期预防治疗遗传性和获得性C1酯酶抑制剂缺乏症患者的回顾性分析：真实世界数据
Felix Johnson,Anna Stenzl,Benedikt Hofauer et al.
Felix Johnson et al.
Hereditary angioedema (HAE) and acquired C1-inhibitor deficiency (AAE-C1-INH) are orphan diseases. Berotralstat is a recently licensed long-term prophylaxis (LTP) and the first oral therapy for HAE patients. No approved therapies exist for ...
Advancing Treatment in Bullous Pemphigoid: A Comprehensive Review of Novel Therapeutic Targets and Approaches [0.03%]
新型治疗靶点和治疗方法视域下的大疱性 pemphigoid 综述
Hsuan-Chi Chen,Chuang-Wei Wang,Wu Han Toh et al.
Hsuan-Chi Chen et al.
Bullous pemphigoid is one of the most common autoimmune bullous diseases occurring primarily in the elderly. Pathogenic autoantibodies against BP180 and BP230 at the dermal-epidermal junction cause subepidermal blisters, erosions, and inten...
Gaia Bruschi,Daniele Giovanni Ghiglioni,Laura Cozzi et al.
Gaia Bruschi et al.
Vernal keratoconjunctivitis (VKC) is a chronic, bilateral corneal and conjunctival problem which typically presents in young individuals. VKC is characterized by itching, photophobia, white mucous discharge, lacrimation, foreign body sensat...
Francesco Amati,Gabriele Bongiovanni,Antonio Tonutti et al.
Francesco Amati et al.
Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically characterized by vascular abnormalities and inflammatory and fibrotic involvement of the skin and internal organs resulti...
Hypersensitivity Reactions to Taxanes: A Comprehensive and Systematic Review of the Efficacy and Safety of Desensitization [0.03%]
紫杉烷类药物超敏反应的脱敏治疗疗效及安全性综合系统评价
Rosalaura Virginia Villarreal-González,Sandra González-Díaz,Oscar Vidal-Gutiérrez et al.
Rosalaura Virginia Villarreal-González et al.
Taxanes in the treatment of cancer are associated with a significant incidence of hypersensitivity reactions, which may preclude their use in patients in need of first line therapy. Drug desensitization induces transient immunological toler...
Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity [0.03%]
EB病毒、SARS-CoV-2与HLAⅠ类分子结合基序的致病性特点和序列及其在自身免疫中的潜在作用
Yekbun Adiguzel,Naim Mahroum,Sylviane Muller et al.
Yekbun Adiguzel et al.
Epstein-Barr virus (EBV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are extraordinary in their ability to activate autoimmunity as well as to induce diverse autoimmune diseases. Here we reviewed the current knowledge o...
Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence [0.03%]
过敏性鼻炎的环境危险因素、保护因素和生物标志物证据的系统伞状回顾
Xianpeng Xu,Xinghong Liu,Jiongke Li et al.
Xianpeng Xu et al.
Many potential environmental risk factors, protective factors, and biomarkers of AR have been published, but so far, the strength and consistency of their evidence are unclear. We conducted a comprehensive review of environmental risk, prot...
Uei-Hsiang Hsu,Bor-Luen Chiang
Uei-Hsiang Hsu
Gamma-delta (γδ) T cells play an essential role in allergic diseases and have emerged as a potential treatment target in recent decades. To clarify the effects of γδ T cells on atopic illnesses, we reviewed the literature on the physica...