Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm [0.03%]
过敏和自身免疫之间的临床和病理生理关系：拆解传统的二元论框架
Giuseppe A Ramirez,Chiara Cardamone,Sara Lettieri et al.
Giuseppe A Ramirez et al.
Allergic and autoimmune disorders are characterised by dysregulation of the immune responses to otherwise inert environmental substances and autoantigens, leading to inflammation and tissue damage. Their incidence has constantly increased i...
Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders [0.03%]
自身免疫性疾病相关的T细胞和B细胞的新兴机制与生物标志物
Azhagu Madhavan Sivalingam
Azhagu Madhavan Sivalingam
Autoimmune diseases are characterized by the dysregulation of B-cells, which are responsible for antibody production against pathogens, and T-cells, which play a crucial role in cell-mediated immunity, including both helper and cytotoxic T-...
Limei Cui,Yujuan Yang,Yan Hao et al.
Limei Cui et al.
Under the concept of "one airway, one disease", upper and lower airway inflammatory diseases share similar pathogenic mechanisms and are collectively referred to as airway inflammatory diseases. With industrial development and environmental...
Jiayan Zhang,Guofang Li,Qiuyang Guo et al.
Jiayan Zhang et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex relationship to allergens. While AD itself is not an allergic reaction and does not necessarily involve allergen sensitization, AD patients show higher rates of se...
Macrophages Unmasked: Their Pivotal Role in Driving Atherosclerosis in Systemic Lupus Erythematosus [0.03%]
巨噬细胞在系统性红斑狼疮动脉粥样硬化发病机制中的关键作用
Chao Wang,Bingxing Chen,Xiaochen Yu et al.
Chao Wang et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease that significantly increases the risk of cardiovascular diseases, particularly atherosclerosis (AS). Understanding the shared pathogenic mechanisms underlying SLE and AS is crucial...
Immunological Effects of Electronic Cigarette Use: A Review of Current Evidence [0.03%]
电子烟的免疫学影响：现有证据综述
Katarzyna Zima,Aleksandra Bogucka,Miłosz Wojtas et al.
Katarzyna Zima et al.
Electronic cigarettes (EC) have emerged as a popular alternative to traditional tobacco products, but their impact on immune function has raised significant health concerns. This review explores the immunological effects of EC exposure, foc...
TTC7A Variants Results in Gastrointestinal Defects and Immunodeficiency Syndrome: Case Series and Literature Review [0.03%]
TTC7A突变导致胃肠缺陷和免疫缺陷综合征的病例系列及文献回顾
Zhaowei Huang,Xiufang Zhi,Qiuyu Geng et al.
Zhaowei Huang et al.
Gastrointestinal Defects and Immunodeficiency Syndrome-1 (GIDID-1), caused by abnormalities in TTC7A, is an autosomal recessive disorder characterized by multiple gastrointestinal malformations and immune deficiencies, often accompanied by ...
Short-Chain Fatty Acids: Promising Therapeutic Targets for Respiratory Syncytial Virus Infection [0.03%]
短链脂肪酸：潜在的治疗呼吸道合胞病毒感染靶点
Mingxin Liang,Qinqin Dong,Weiyi Wu et al.
Mingxin Liang et al.
The intestinal microbiota is a complex community of organisms present in the human gastrointestinal tract, some of which can produce short-chain fatty acids (SCFAs) through the fermentation of dietary fiber. SCFAs play a major role in media...
Histone Modifications and DNA Methylation in Psoriasis: A Cellular Perspective [0.03%]
银屑病的组蛋白修饰及DNA甲基化：细胞视角
Jing Pan,Siji Chen,Xianzhen Chen et al.
Jing Pan et al.
In recent years, epigenetic modifications have attracted significant attention due to their unique regulatory mechanisms and profound biological implications. Acting as a bridge between environmental stimuli and changes in gene activity, th...
Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications [0.03%]
外泌体在自身免疫性疾病中的机制和诊断应用研究进展
Lina Duan,Wanying Lin,Yi Zhang et al.
Lina Duan et al.
Exosomes, small extracellular vesicles secreted by various cell types, have emerged as key players in the pathophysiology of autoimmune diseases. These vesicles serve as mediators of intercellular communication, facilitating the transfer of...