Hereditary Angioedema with Normal C1 Inhibitor: an Updated International Consensus Paper on Diagnosis, Pathophysiology, and Treatment [0.03%]
C1抑制物正常的遗传性血管性水肿：最新国际共识文件关于诊断，病理生理学和治疗的内容
Bruce L Zuraw,Konrad Bork,Laurence Bouillet et al.
Bruce L Zuraw et al.
Hereditary angioedema (HAE) has been recognized for almost 150 years. The newest form of HAE, where C1 inhibitor levels are normal (HAE-nC1INH), was first described in 2000. Over the last two decades, new types of apparent non-mast cell-med...
Review of the Pathophysiology and Clinical Manifestations of 22q11.2 Deletion and Duplication Syndromes [0.03%]
22q11.2缺失和重复综合征的病理生理学和临床表现回顾
Jeremy Purow,Lauren Waidner,Hanadys Ale
Jeremy Purow
22q11.2 deletion and duplication syndromes are complex genetic syndromes composed of a wide spectrum of clinical manifestations, mostly affecting cardiovascular, endocrine, neurodevelopmental, and immune functioning. 22q11.2 deletion syndro...
Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia [0.03%]
免疫和非免疫相互作用在雄性激素源性脱发发病机理中的作用
Yu Xiao,Yi Zhang,Shuting Deng et al.
Yu Xiao et al.
Androgenetic alopecia (AGA), a leading cause of progressive hair loss, affects up to 50% of males aged 50 years, causing significant psychological burden. Current treatments, such as anti-androgen drugs and minoxidil, show heterogeneous eff...
Mesenchymal Stromal Cell-Based Therapy: A Promising Approach for Autoimmune Diseases [0.03%]
间充质基质细胞疗法：一种有前景的自身免疫性疾病治疗方法
Liming Li,Yong He,Junpeng Zhao et al.
Liming Li et al.
Autoimmune diseases are characterized by immune dysregulation, resulting in aberrant reactivity of T cells and antibodies to self-antigens, leading to various patterns of inflammation and organ dysfunction. However, current therapeutic agen...
Immunomodulatory Significance of Mast Cell Exosomes (MC-EXOs) in Immune Response Coordination [0.03%]
肥大细胞外泌体(MC-EXO)在免疫反应协调中的免疫调节意义
Daniel Elieh-Ali-Komi,Farzaneh Shafaghat,Shamila D Alipoor et al.
Daniel Elieh-Ali-Komi et al.
Mast cells (MCs) communicate with other cells by direct cell-to-cell interaction, secreting mediators, and releasing exosomes (EXOs). MC-exosomes (MC-EXOs) contain proteins, lipids, mRNAs, and noncoding RNAs (ncRNAs), exhibit typical EXO ma...
Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine [0.03%]
过敏性鼻炎中的多组学研究：机制分析与精准医学
Yan Hao,Yujuan Yang,Hongfei Zhao et al.
Yan Hao et al.
Allergic rhinitis (AR) is a common chronic inflammatory airway disease caused by inhaled allergens, and its prevalence has increased in recent decades. AR not only causes nasal leakage, itchy nose, nasal congestion, sneezing, and allergic c...
Age-Associated B Cells in Autoimmune Diseases: Pathogenesis and Clinical Implications [0.03%]
自身免疫性疾病中的年龄相关B细胞：发病机制和临床意义
Guangyang Xie,Xiaojing Chen,Yixia Gao et al.
Guangyang Xie et al.
As a heterogeneous B cell subset, age-associated B cells (ABCs) exhibit distinct transcription profiles, extrafollicular differentiation processes, and multiple functions in autoimmunity. TLR7 and TLR9 signals, along with IFN-γ and IL-21 s...
Allergic Reactions in Dental Practice: Classification of Medicines, Mechanisms of Action, and Clinical Manifestations [0.03%]
牙科实践中药物的过敏反应：药物分类、作用机制及临床表现
Maria Zofia Lisiecka
Maria Zofia Lisiecka
Allergic reactions in dental practice have been a serious problem, causing various clinical symptoms and having a significant impact on the quality of dental care. This study examined various aspects of allergic reactions, their causes, mec...
Crosstalk Between the Skin Environment and Microbial Community in Immune-Related Skin Diseases [0.03%]
免疫相关皮肤病的皮肤环境和微生物群之间的相互作用
Kecheng Liu,Shuting Deng,Yuan Zhou et al.
Kecheng Liu et al.
The skin surface hosts diverse skin microbiota, including bacteria, fungi, and viruses. Intricate interactions between the skin microenvironment and microbial community are crucial for maintaining cutaneous homeostasis. This review explores...
Keni Chang,Peiming Luo,Zizhen Guo et al.
Keni Chang et al.
Sjögren's syndrome (SS) is a chronic autoimmune disorder that primarily affects the exocrine glands. Due to the intricate nature of the disease progression, the exact mechanisms underlying SS are not completely understood. Recent research ...