Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma [0.03%]
哮喘中的IL-13和IL-4靶向治疗对重度哮喘气道重塑的治疗意义
Lina Sahnoon,Khuloud Bajbouj,Bassam Mahboub et al.
Lina Sahnoon et al.
Asthma is a chronic respiratory disorder affecting individuals across all age groups. It is characterized by airway inflammation and remodeling and leads to progressive airflow restriction. While corticosteroids remain a mainstay therapy, t...
Inhalant Mediated Allergy: Immunobiology, Clinical Manifestations and Diagnosis [0.03%]
吸入性过敏：免疫生物学、临床表现及诊断方法
Ki Lam,Elaine Au,W K Ip et al.
Ki Lam et al.
Inhalant allergen-mediated respiratory diseases, including asthma and allergic rhinitis, have become increasing global health issues. While air pollution is believed to favor allergic sensitization and intensify clinical symptoms of allergy...
Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential [0.03%]
系统性红斑狼疮的肠道微生物研究：见解与生物标志物发现潜力
Lingyue Jin,Jie Xiao,Yuhong Luo et al.
Lingyue Jin et al.
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by chronic inflammation and multi-organ damage, influenced by genetic, environmental, and immunological factors. Recent research highlights the significant rol...
Osteoimmunology: Crosstalk Between T Cells and Osteoclasts in Osteoporosis [0.03%]
骨免疫学：T细胞和破骨细胞在骨质疏松症中的相互作用
Zeyao Lu,Peilun Xiao,Shijia Liu et al.
Zeyao Lu et al.
Osteoporosis, a common metabolic condition that affects the bones, increases the risk of fractures, thereby diminishing one's quality of life and, in severe cases, can even result in life-threatening conditions. Osteoporosis is becoming inc...
Tao Liu,Bo Chen,Geng Yin et al.
Tao Liu et al.
Idiopathic inflammatory myopathy (IIM) is a group of heterogeneous diseases that can affect multiple systems. Currently, it is classified into different subtypes based on myositis-specific antibodies and muscle tissue pathology. These subty...
Xin Huang,Jing Zhu,Tianqi Wei et al.
Xin Huang et al.
Vitiligo is an autoimmune depigmenting skin disorder and can affect the mental health of the patients. Current research suggests that the development of vitiligo involves a combination of genetic susceptibility, immune imbalance, and oxidat...
Effectiveness and Safety of Nemolizumab in Patients with Prurigo Nodularis: a Systematic Review and Meta-Analysis of Randomized Controlled Trials [0.03%]
纳莫利珠单抗治疗结节性痒疹有效性和安全性的系统评价和meta分析
Ahsan Raza Raja,Zoha Zahid Fazal,Aisha Sethi
Ahsan Raza Raja
Prurigo nodularis (PN) is a chronic, severely pruritic condition that markedly impairs quality of life. Existing treatments show limited efficacy, prompting investigation of nemolizumab, an IL-31 receptor antagonist. This meta-analysis eval...
Molecular Allergology: Epitope Discovery and Its Application for Allergen-Specific Immunotherapy of Food Allergy [0.03%]
分子过敏学：过敏原特异性免疫疗法的食物过敏表位鉴定及应用研究进展
Fei Huan,Shuai Gao,Yi Gu et al.
Fei Huan et al.
The prevalence of food allergy continues to rise, posing a significant burden on health and quality of life. Research on antigenic epitope identification and hypoallergenic agent design is advancing allergen-specific immunotherapy (AIT). Th...
The Impact of Mast Cells on the Anatomy, Cellular Communication, and Molecular Immune Network of Lymph Nodes [0.03%]
关于肥大细胞对淋巴结解剖学、细胞通讯及分子免疫网络的影响
Daniel Elieh-Ali-Komi,Marcus Maurer,Frank Siebenhaar
Daniel Elieh-Ali-Komi
Lymph nodes (LNs) are ovoid-shape capsulated structures interposed along the lymphatic vessels. Owing to their unique architecture, LNs place immune cell types in distinct compartments allowing effective contact of antigens to them. Their e...
Sixing Wang,Zilin Mei,Jin Chen et al.
Sixing Wang et al.
Congenital heart defects (CHD) are the most common major birth defects and one of the leading causes of death from congenital defects after birth. CHD can arise in pregnancy from the combination of genetic and non-genetic factors. The mater...