Recombinant BCG Expressing IL-12 as A Novel Immunomodulatory Strategy for Allergic Asthma: Opportunities and Challenges [0.03%]
表达IL-12的重组卡介苗作为过敏性哮喘免疫调节策略的新方法：机遇与挑战
Romina Campos-Povea,Enrique González-Madrid,Tays Troncoso-Bravo et al.
Romina Campos-Povea et al.
Allergic asthma is a chronic respiratory disorder driven by a T helper type 2 (Th2)-mediated immune response that involves eosinophils and mast cell recruitment to affected tissues, eliciting inflammatory cytokines and IgE production. Typic...
IL-17-Related Pathways and Myeloid Cell Function are Involved in the Mechanism of Sublingual Immunotherapy with Artemisia annua for Seasonal Allergic Rhinitis [0.03%]
咽部免疫治疗季节性过敏性鼻炎的机制与IL-17相关通路及髓系细胞功能有关
Yan Zhao,Song Mei,Shuang Yao et al.
Yan Zhao et al.
The mechanisms underlying immune tolerance induction during sublingual immunotherapy (SLIT) of seasonal allergic rhinitis (SAR) remain insufficiently understood. This study aimed to investigate the molecular and immunological process involv...
Allergic Rhinitis is Associated with Increased Suicidality: A Systematic Review and Meta-Analysis [0.03%]
过敏性鼻炎与自杀行为增加有关：系统评价和荟萃分析
Simon Høj,Frederik Kronvold Nielsen,Bo Chawes et al.
Simon Høj et al.
Allergic rhinitis (AR) is a common inflammatory condition affecting millions globally. Emerging evidence suggests a potential link between AR and suicidality; however, this association remains underexplored compared to other atopic diseases...
Sex Bias in Systemic Sclerosis: from Clinical to Immunological Differences [0.03%]
系统性硬化症的性别差异：从临床到免疫学的区别
Lazaros I Sakkas,Dimitrios P Bogdanos,Ian C Chikanza
Lazaros I Sakkas
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvasculopathy, extensive fibrosis, and autoantibodies. The disease affects mostly the female sex. In this review, we highlight sex bias in clinical manifestations...
Macrophage-Centric Immunometabolic Crosstalk in Alopecia Areata Pathogenesis: Mechanisms and Therapeutic Implications [0.03%]
斑秃发病机制中的巨噬细胞免疫代谢交叉 talk：机制和治疗意义
Xu Liu,Xiuzu Song
Xu Liu
Although alopecia areata (AA) is recognized as a hair loss disorder stemming from the dysregulation of cutaneous immune homeostasis, its precise pathogenesis still remains elusive. The collapse of hair follicle (HF) immune privilege (IP), l...
Atopic Dermatitis: The Relationship Between Immune Mediators and Skin Lipid Barrier [0.03%]
特应性皮炎：免疫介质与皮肤脂质屏障之间的关系
Huayan You,Yunsheng Liang
Huayan You
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is prevalent worldwide with complex etiology. Skin barrier defects and abnormal immune activation are crucial in the occurrence and development of AD. In the classic model o...
Molecular Diagnosis to IgE-mediated Wheat Allergy and Wheat-Dependent Exercise-Induced Anaphylaxis [0.03%]
基于IgE介导的小麦过敏和运动诱发性过敏的分子诊断学研究进展
Witchaya Srisuwatchari,Kantima Kanchanapoomi,Punchama Pacharn
Witchaya Srisuwatchari
IgE-mediated wheat allergy is an emerging problem worldwide, particularly prevalent in Northern Europe and parts of Asia. Another unique manifestation of wheat allergy, wheat-dependent exercise-induced anaphylaxis (WDEIA), and hydrolyzed wh...
Neutrophilic Urticarial Dermatosis: A Window into Systemic Inflammation and Autoimmune Disorders [0.03%]
中性粒细胞血管炎样荨麻疹：系统性炎症和自身免疫疾病的窗口
Xiaoxuan Cai,Yihe Zheng,Changyi Yang et al.
Xiaoxuan Cai et al.
Neutrophilic urticarial dermatosis (NUD) is a distinctive dermatological manifestation that is commonly associated with systemic autoinflammatory and autoimmune diseases. This review comprehensively explores NUD in the context of five major...
Jiani Li,Meng Wang,Jing Yang et al.
Jiani Li et al.
Enhancer of zeste homolog 2 (EZH2), a protein encoded by the EZH2 gene, is a crucial subunit in polycomb repressive complex 2. EZH2 controls the transcription of genes critical for cell proliferation, differentiation, amplification, and fun...
Questionnaire for Clinical Diagnosis of House Dust Mite's Allergy Approved by Delphi Consensus [0.03%]
尘螨过敏临床诊断问卷德尔菲专家共识版
Angelica Tiotiu,Fulvio Braido,Krysztof Kowal et al.
Angelica Tiotiu et al.
Despite house dust mite (HDM)-allergy is the most frequent in the world, no standard questionnaire exists to help physicians in their clinical practice for screening patients with this possible diagnosis. The objective of this survey was to...