Wesley H Brooks
Wesley H Brooks
Autoimmune diseases appear to have multiple contributing factors including genetics, epigenetics, environmental factors, and aging. The predominance of females among patients with autoimmune diseases suggests possible involvement of the X c...
Esteban Ballestar
Esteban Ballestar
The existence of phenotypic differences between monozygotic (MZ) twins is a prime case where the relationship between genetic determinants and environmental factors is illustrated. Although virtually identical from a genetic point of view, ...
Annabelle Grolleau-Julius,Donna Ray,Raymond L Yung
Annabelle Grolleau-Julius
The decline in immunocompetence with age is accompanied by the increase in the incidence of autoimmune diseases. Aging of the immune system, or immunosenescence, is characterized by a decline of both T and B cell function, and paradoxically...
Moshe Szyf
Moshe Szyf
Several lines of evidence suggest the involvement of disturbance in epigenetic processes in autoimmune disease. Most noteworthy is the global DNA hypomethylation seen in lupus. Epigenetic states in difference from genetic lesions are potent...
Yves Renaudineau,Soizic Garaud,Christelle Le Dantec et al.
Yves Renaudineau et al.
Autoreactive B cells are central in the pathogenesis of autoimmune diseases (AID) not only by producing autoantibodies but also by secreting cytokines and by presenting autoantigens. Changes in DNA methylation, histone modifications, and mi...
H David Pettigrew,Suzanne S Teuber,James S Kong et al.
H David Pettigrew et al.
Mastocytosis denotes a wide range of disorders characterized by having abnormal growth and accumulation of mast cells. Mast cells contain histamine and other inflammatory mediators, which have diverse actions within the body, and play cruci...
Epigenetic perspectives in systemic lupus erythematosus: pathogenesis, biomarkers, and therapeutic potentials [0.03%]
系统性红斑狼疮的表观遗传学研究：发病机制、生物标志物和治疗潜力
Sha Zhao,Hai Long,Qianjin Lu
Sha Zhao
System lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that cause widespread tissue damage. The underlying etiology remains largely unknown. Aberrant epigenetics plays essential ro...
Yves Renaudineau
Yves Renaudineau
Autoimmunity is believed to develop when genetically predisposed individuals encounter epigenetic modifications in response to environmental factors. Recent advances in the understanding of epigenetic mechanisms, their contribution to the i...
Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope [0.03%]
乳糜泻的诊断难题及组织转谷氨酰胺酶 neo-表位的作用
Torsten Matthias,Sascha Pfeiffer,Carlo Selmi et al.
Torsten Matthias et al.
The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in partic...
Anupama Bhat,Carlo Selmi,Stanley M Naguwa et al.
Anupama Bhat et al.
Amyloidosis is defined as the extracellular accumulation at systemic or organ-specific level of insoluble low molecular weight protein fibrils manifesting a beta pleated sheet configuration and a characteristic staining pattern. Several dif...