Lapatinib Induces Ferroptosis in Cardiomyocytes by Regulating ATF4/GPX4 [0.03%]
拉帕替尼通过调节ATF4/GPX4诱导心肌细胞铁死亡
Yue Sun,Keyi Jiang,Dan Wang et al.
Yue Sun et al.
The TKI-targeted agent lapatinib has been applied in clinical oncology for the management of multiple malignancies. Nonetheless, its therapeutic benefit is restricted by cardiotoxic effects that endanger patient survival, and the underlying...
Tnxb Alleviates Myocardial Ischemia-Reperfusion Injury Through Facilitating Akt-Dependent Endothelial Cell Survival and Angiogenesis in Mice [0.03%]
藤黄素通过促进Akt依赖的内皮细胞存活和新生血管形成从而减轻小鼠心肌缺血再灌注损伤的作用及机制研究
Haohao Hao,Xiaolin Zi,Yunhao Jiang et al.
Haohao Hao et al.
Tenascin-X (Tnxb) is a large extracellular matrix protein that has been associated with atherosclerosis. The objective of this study was to investigate the effect of Tnxb and its contribution to recovery after myocardial ischemia/reperfusio...
Methyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy [0.03%]
甲基转移酶METTL1通过m7G依赖的方式上调USF2加速脓毒症心肌病的发生发展并抑制PINK1/Parkin介导的线粒体自噬
Wei Dong,Jin Chen,Zhiping Xiong et al.
Wei Dong et al.
Septic cardiomyopathy (SCM) is a severe complication of sepsis, characterized by high mortality. The activation of mitophagy in cardiomyocytes is crucial for alleviating SCM. The N7-methylguanosine (m7G) modification mediated by methyltrans...
Micro- and Nanoplastics in Cardiovascular Toxicology: Human Tissue Detection, Clinical Phenotypes, and Adverse Outcome Signals [0.03%]
微塑料和纳米塑料在心血管毒理学中的研究：人体组织检测、临床表型及不良结果信号
Guangzhen Lu,Xiaoting Wang,Hong Zhuang et al.
Guangzhen Lu et al.
Micro- and nanoplastics (MNPs) have emerged from a diffuse environmental concern to a plausible cardiovascular exposure with potential clinical relevance. The current evidence base is heterogeneous: human observational and tissue-detection ...
SIRT5 Attenuates Doxorubicin-Induced Acute Cardiac Injury by Modulating PHB2 Succinylation and the Mitophagic Response [0.03%]
SIRT5通过调节PHB2琥珀酰化和线粒体自噬反应来减弱多柔比星引起的心脏急性损伤
Aihui Zeng,Haiqiong Liu,Xudong Song et al.
Aihui Zeng et al.
Doxorubicin (DOX)-induced cardiac injury remains a major limitation of chemotherapy and is closely linked to mitochondrial dysfunction, oxidative stress, and dysregulated mitophagy. Sirtuin 5 (SIRT5), a mitochondrial deacylation-related pro...
Nanoparticle-Encapsulated 5-Azacytidine Attenuates Air Pollution-Induced Human Cardiac Fibroblast Activation [0.03%]
纳米颗粒包封的5-氮杂胞苷可减轻空气污染诱导的人心脏成纤维细胞活化
Narainrit Karuna,Wan Wiriya,Kantaporn Kheawfu et al.
Narainrit Karuna et al.
Quasi-ultrafine particles (qUFPs; particulate matter < 0.49 μm; PM0.49) exposure is a key environmental contributor to cardiovascular disease, but its epigenetic impact on human cardiac fibroblasts (HCFs) remains unclear. Dysregulated DNMT...
Associations Between Welding-Related Metals and Atherosclerotic Cardiovascular Disease Risk in Male Welders: The Mediating Role of Accelerated Biological Aging [0.03%]
金属焊接与男性焊工动脉粥样硬化性心血管病风险的关联：加速生物衰老的介导作用
Yongbin Luo,Xiayun Dai,Zhenlong Chen et al.
Yongbin Luo et al.
The impact of metals on atherosclerotic cardiovascular disease (ASCVD) risk in workers occupationally exposed to welding fume remains unclear. We aimed to assess the associations between welding-related metals and 10-year ASCVD risk, and th...
Incretin-Based Therapies in Doxorubicin-Induced Cardiotoxicity: A Systematic Review of GLP-1 and Dual GIP/GLP-1 Agonists [0.03%]
多柔比星诱导的心脏毒性的基于肠泌素的疗法：GLP-1和双GIP / GLP-1激动剂的系统性综述
Seyedhesamoddin Khatami,Mohammadsadegh Faghihi,Ghazal Tavakoli et al.
Seyedhesamoddin Khatami et al.
Doxorubicin (DOX)-induced cardiotoxicity remains a major limitation of cancer therapy. Incretin-based therapies are established cardiometabolic agents with pleiotropic cardiovascular effects; however, their potential role in mitigating DOX-...
The mtROS-Mitophagy Axis: A Decisive Redox Hub Governing Cell Fate in Myocardial Ischemia-Reperfusion Injury [0.03%]
线粒体ROS-自噬轴：心肌缺血再灌注损伤中调控细胞命运的关键氧化还原中心
Wei Wang,Zhihao Xu,Wei Liu et al.
Wei Wang et al.
The progression of myocardial ischemia-reperfusion injury (MIRI) is orchestrated by a decisive, bidirectional dialogue between mitochondrial reactive oxygen species (mtROS) and mitophagy. This review advances the concept of a dynamic "mtROS...
The Neuroimmune Mechanisms Linking Smoking and Infection to Atherosclerosis: Chronic vs. Surge [0.03%]
吸烟和感染与动脉粥样硬化的神经免疫机制：慢性与急性反应
Paulo Roberto Benchimol-Barbosa
Paulo Roberto Benchimol-Barbosa
The pathogenesis of atherosclerosis has progressively shifted from a lipid-centric model to one that recognizes inflammation as the central driver. Smoking is a well-established chronic risk factor, whereas acute infections are increasingly...