Loss of cytochrome P450 17A1 protein expression in a 17alpha-hydroxylase/17,20-lyase-deficient 46,XY female caused by two novel mutations in the CYP17A1 gene [0.03%]
CYP17A1基因的两个新突变导致17α-羟化酶/17，20-裂解酶缺乏症纯合子患者细胞色素P450 17A1蛋白表达缺失
Nayelli Nájera,Nayely Garibay,Yadira Pastrana et al.
Nayelli Nájera et al.
17alpha-Hydroxylase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia caused by mutations in the CYP17A1 gene. This condition shows considerable clinical and biochemical variation. Molecular characterization of novel mutat...
Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases [0.03%]
肿瘤转移到甲状腺乳头状癌滤泡型变异的两种罕见病例的组织病理学、免疫组化和分子研究
Jing Yu,Marina N Nikiforova,Steven P Hodak et al.
Jing Yu et al.
Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumo...
Case report: Adrenal LH/hCG receptor overexpression and gene amplification causing pregnancy-induced Cushing's syndrome [0.03%]
病例报告：妊娠诱发的库欣综合征由肾上腺LH/hCG受体过度表达和基因扩增引起
Michael Herman Chui,Nese Colak Ozbey,Shereen Ezzat et al.
Michael Herman Chui et al.
Transient pregnancy-induced Cushing's syndrome (CS) is extremely rare, with only several cases reported in the literature. Ectopic LH/hCG-receptors (LHCGR) in the adrenal gland have been suggested to be involved in the pathogenesis of this ...
Ewa Jasek,Alicja Furgal-Borzych,Grzegorz J Lis et al.
Ewa Jasek et al.
Microvessel density (MVD) and area (MVA) were assessed in 53 clinically silent pituitary microadenomas and in surrounding normal pituitary tissue using CD34 immunostaining and digital image analysis system. Twenty-one microadenomas (40%) we...
A case of amyloid goiter associated with intrathyroid parathyroid and lymphoepithelial cyst [0.03%]
与甲状腺内甲状旁腺和淋巴上皮囊相关的淀粉样变性甲状腺肿病例报告
Asmaa G Abdou,Mona A Kandil
Asmaa G Abdou
Diffuse enlargement of the thyroid gland accompanied by an interstitial tissue deposition of amyloid is a special entity termed an amyloid goiter. An amyloid goiter is a rare thyroid lesion, which has been described a long time ago. In this...
The correlation between intestinal gonadotropin-releasing hormone (GnRH) and proglucagon in hyperlipidemic rats and Goto-Kakizaki (GK) rats [0.03%]
高脂血症大鼠和GK糖尿病模型大鼠肠 GnRH 与 Proglucagon 相关性研究
Li Wang,Jing Wu,Hongwei Cao et al.
Li Wang et al.
Our experiment investigated the mRNA expression of intestinal gonadotropin-releasing hormone (GnRH), proglucagon (PG), and glucagon-like peptide 1 receptor (GLP-1R) in the jejunum, ileum, and colon of rats fed with high-fat diet and Goto-Ka...
Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass [0.03%]
以胰腺肿物表现为神经节细胞瘤样的副神经节瘤一例报告
Frediano Inzani,Guido Rindi,Ernesto Tamborrino et al.
Frediano Inzani et al.
Paragangliomas may have composite forms in which they combine features of a typical paraganglioma with those of a neural component consisting of either neuroblastoma, ganglioneuroblastoma, or ganglioneuroma. These variants are rare and gene...
Vasculopathic changes, a somatostatin-producing neuroendocrine carcinoma and a jejunal gastrointestinal stromal tumor in a patient with type 1 neurofibromatosis [0.03%]
1型神经纤维瘤病患者的血管病变、生长抑素产生性类癌和小肠间质肿瘤
Runjan Chetty,Rajkumar Vajpeyi
Runjan Chetty
A 36-year-old male with neurofibromatosis type 1 (NF-1) presented with symptoms of obstructive jaundice. Imaging showed a periampullary mass, which on endoscopic retrograde cholangiopancreatography biopsy proved to be a somatostatinoma. A W...
Insulin prevents latent skin lesions by inhibiting the generation of advanced glycation end products in streptozotocin-induced diabetic rats [0.03%]
胰岛素通过抑制链脲佐菌素诱导的糖尿病大鼠晚期糖基化终末产物的形成预防潜行性皮肤损伤
Xiangfang Chen,Weidong Lin,Shuliang Lu et al.
Xiangfang Chen et al.
The preventive effect of insulin on latent skin lesions in streptozotocin-induced diabetic rats was investigated. Diabetes was induced in 72 male Sprague-Dawley rats, with 36 rats serving as the control group. Half of the diabetic rats were...
Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions [0.03%]
伴有瘤细胞合体样变性和胞质嗜酸性小体包涵的肾上腺皮质醛固酮腺瘤
Ozgur Mete,Sylvia L Asa
Ozgur Mete
We report an interesting morphological alteration in the adrenal of a 72-year-old woman suffering from severe hypertension due to primary hyperaldosteronism. The laparoscopic left adrenalectomy specimen revealed an adrenal cortical adenoma ...