Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance [0.03%]
基于拉普拉斯方差的甲状腺液基细胞学全片扫描图像聚焦质量量化评估方法研究
Chan Kwon Jung,Chankyung Kim,Sora Jeon et al.
Chan Kwon Jung et al.
Reliable focus is essential for digital cytopathology, yet three-dimensional cell clusters in liquid-based cytology (LBC) slides pose persistent challenges for single-plane whole-slide imaging. We sought to quantitatively compare focus perf...
Multi-center Assessment of DLL3 Expression by Immunohistochemistry in Medullary Thyroid Carcinoma [0.03%]
多中心评价免疫组化检测甲状腺髓样癌DLL3表达
Ignacio Ruz-Caracuel,Alejandra Rosell,Lucie Geryková et al.
Ignacio Ruz-Caracuel et al.
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy accounting for 1-2% of thyroid carcinomas. As a neuroendocrine neoplasm, it shares molecular features with other aggressive neuroendocrine carcinomas, including alteratio...
Multicenter Study
Endocrine pathology. 2025 Dec 5;36(1):49. DOI:10.1007/s12022-025-09894-9 2025
Eleni Armeni,Tu-Vinh Luong,Ashley Grossman
Eleni Armeni
Endocrine and neuroendocrine malignancies, including epithelial neuroendocrine neoplasms (NENs), phaeochromocytoma/paraganglioma (PPGL), adrenocortical carcinoma (ACC) and thyroid cancers, represent a heterogeneous group of tumours often ch...
Correction to: Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in MEN1/DAXX/ATRX Explain Biological Variability [0.03%]
Correction to：MEN1/DAXX/ATRX基因突变的胰腺神经内分泌肿瘤分子亚型解释了生物变异性
Simona Avanthay,Annunziata Di Domenico,Philipp Kirchner et al.
Simona Avanthay et al.
Published Erratum
Endocrine pathology. 2025 Nov 26;36(1):47. DOI:10.1007/s12022-025-09892-x 2025
Follicular Thyroid Carcinoma Relapse Cases - Revisited by X-ray 3D Virtual Histology [0.03%]
滤泡型甲状腺癌复发病例的X射线三维虚拟组织学再评估
Kiarash Tajbakhsh,Olga Stanowska,Jonas Bossart et al.
Kiarash Tajbakhsh et al.
The diagnosis and prognosis of follicular thyroid neoplasms are based on the identification of capsular and vascular invasion. Although conventional histology allows accurate classification in most cases, its inherent limitations in tissue ...
Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in MEN1/DAXX/ATRX Explain Biological Variability [0.03%]
MEN1/DAXX/ATRX基因突变的胰腺神经内分泌肿瘤分子亚型解释了生物学差异
Simona Avanthay,Annunziata Di Domenico,Philipp Kirchner et al.
Simona Avanthay et al.
About 40% of non-functioning (NF) Pancreatic Neuroendocrine Tumors (PanNETs) harbour mutations in MEN1, often co-occurring with DAXX/ATRX. While the ADM group (MEN1 and DAXX/ATRX co-mutated) exhibits homogeneous genetic and epigenetic featu...
Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome [0.03%]
肺神经内分泌肿瘤的表型谱系：由OTP / ASCL1表达分型并结合组织学，激素和预后进行相关性分析
Ayako Ura,Katja Evert,Matthias Evert et al.
Ayako Ura et al.
Recent studies have shown that pulmonary neuroendocrine tumor (NET) subgroups, defined by the transcription factors OTP and ASCL1, correlate with age, sex, and tumor location. Their relationships with histology and hormone production, howev...
Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy [0.03%]
烷化剂化疗后免疫治疗高突变负荷和错配修复异常的转移性胰腺神经内分泌肿瘤
Louis de Mestier,Thorvardur R Halfdanarson,Leonidas Apostolidis et al.
Louis de Mestier et al.
Alkylating agent-based chemotherapy is one of the main treatment options for patients with metastatic pancreatic neuroendocrine tumors (PanNETs).However, it favors the acquisition of a hypermutator phenotype, suggesting a potential benefit ...
Correction to: TERT Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival [0.03%]
Correction to: TERT扩增是乳头状甲状腺癌的风险分层标志物，与肿瘤复发和生存显著相关
Sara Gil-Bernabé,Noa Feás-Rodríguez,Enrique Pérez-Riesgo et al.
Sara Gil-Bernabé et al.
Published Erratum
Endocrine pathology. 2025 Oct 30;36(1):41. DOI:10.1007/s12022-025-09881-0 2025
Performance of Immunohistochemistry to Detect Rb/p53 Alterations in High-Grade Neuroendocrine Neoplasms: Staining Patterns and Comparison with Genetic Testing [0.03%]
免疫组化检测高级别神经内分泌肿瘤Rb/p53异常的效能：染色模式及与基因检测结果对比分析
Ruiqian Chen,Matthieu Tihy,Ludovic Lacroix et al.
Ruiqian Chen et al.
Rb and p53 status helps distinguishing well from poorly differentiated high-grade neuroendocrine neoplasms (HG-NENs) and may predict response to platinum-based chemotherapy. Historically, gene and protein profile correlations for Rb and p53...
Comparative Study
Endocrine pathology. 2025 Oct 29;36(1):40. DOI:10.1007/s12022-025-09885-w 2025