A Cauda Equina Neuroendocrine Tumor with Tyrosine Hydroxylase Expression [0.03%]
带有酪氨酸羟化酶表达的马尾神经内分泌肿瘤病例报告
Knarik Arkun,Zahra Jalali,Mina G Safain et al.
Knarik Arkun et al.
Expansion of Germline Variants in Primary Hyperparathyroidism: Fumarate Hydratase Deficiency as a Cause of Parathyroid Adenomas [0.03%]
特发性原发性甲状旁腺功能亢进的生殖细胞变异扩展：延胡索酸水合酶缺乏导致甲状旁腺腺瘤的原因分析
Hussam Alkaissi,Elias Chuki,Yi Liu et al.
Hussam Alkaissi et al.
A substantial fraction (60-85%) of hereditary primary hyperparathyroidism (hPHPT) lacks an identifiable genetic etiology. We describe fumarate hydratase (FH) mutations as a potential cause of hPHPT, expanding the phenotypic spectrum of FH d...
Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study [0.03%]
肾上腺皮质癌循环肿瘤DNA检测回顾性队列研究
Vania Balderrama-Brondani,Leonardo Marcal,Mohammad Jad Moussa et al.
Vania Balderrama-Brondani et al.
Adrenocortical carcinoma (ACC) is a rare malignancy with high recurrence rates. Circulating tumor DNA (ctDNA) is a minimally invasive, blood-based biomarker with multiple oncologic applications. The role of ctDNA in ACC care remains underst...
Integrated Pathologic, Genomic, and Transcriptomic Analysis of Renal Neuroendocrine Tumors Reveals Neuroendocrine Transcriptional Programs and Associated Gastrointestinal-Type Epithelium in a Subset of Cases [0.03%]
整合病理学、基因组和转录组分析肾神经内分泌肿瘤揭示了一部分病例中的神经内分泌转录程序及相关的胃肠道类型上皮组织
Eric D Young,Riya Dua,Stephen Kwak et al.
Eric D Young et al.
Renal well-differentiated neuroendocrine tumors (RenNETs) are rare primary renal neoplasms with enigmatic histogenesis. To define the molecular features of RenNETs and clarify their relationship to neuroendocrine tumors (NETs) from other si...
Prevalence and Histologic Features of Multifocal Fibrosing Thyroiditis in the Routine Pathology Practice [0.03%]
多灶性硬化性甲状腺炎的流行病学及组织病理特征分析
Floriana Jessica Di Paola,Maria Vittoria Altavilla,Giulia Calafato et al.
Floriana Jessica Di Paola et al.
Multifocal fibrosing thyroiditis (MFT) is a poorly understood condition characterized by multiple fibrotic scar-like lesions with paucicellular core and peripheral follicular cell atypia. Described by Dr. Rosai in 1990 in consultation cases...
An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups [0.03%]
全面整合胰腺神经内分泌肿瘤RNA剪接景观鉴定出临床相关的分子亚型
Ricardo Blázquez-Encinas,Víctor García-Vioque,Andrea Mafficini et al.
Ricardo Blázquez-Encinas et al.
Alterations in alternative splicing are emerging as a novel cancer hallmark, offering new insights into tumor biology. However, integrative analyses of splicing are still scarce, particularly in rare cancers like pancreatic neuroendocrine t...
Distinct ALK Expression Patterns Are Associated with Canonical and Noncanonical STRN::ALK Transcript Architectures in Oncocytic Thyroid Neoplasms [0.03%]
不同类型的ALK表达模式与经典和非经典的STRN::ALK转录结构在甲状腺滤泡性嗜酸细胞肿瘤中的关联性研究
Debora Mota Dias Thomaz,Thais Biude Mendes,Thaise Nayane Ribeiro Carneiro et al.
Debora Mota Dias Thomaz et al.
Oncocytic thyroid carcinomas are characterized by a unique chromosomal landscape and frequent resistance to radioactive iodine therapy, underscoring the need for improved molecular characterization. Although ALK rearrangements, particularly...
Neuroendocrine Tumors of the Gallbladder: A Multicenter Case Series and Systematic Literature Review Indicating Predominantly Non-Aggressive Tumor Behavior and a Common Association with Cholesterol Polyps and Cholesterolosis [0.03%]
胆囊神经内分泌肿瘤：多中心病例系列和系统文献回顾，表明肿瘤行为以非侵袭性为主且常伴有胆固醇息肉和胆固醇沉着病
Alessandro Vanoli,Yue Xue,Atsuko Kasajima et al.
Alessandro Vanoli et al.
Current data on neuroendocrine tumors (NETs) of the gallbladder and cystic duct (GB-NETs) are highly limited, and the available evidence, largely derived from cancer registry data, suggests that these tumors exhibit a substantially more agg...
Multicenter Study
Endocrine pathology. 2026 Jun 11;37(1):26. DOI:10.1007/s12022-026-09921-3 2026
Genomic Catastrophe Defines the Evolutionary Trajectory of Adrenocortical Carcinoma [0.03%]
染色体碎裂定义了肾上腺皮质癌的进化路径
Samuel Backman,Fredrik Axling,Liang Zhang et al.
Samuel Backman et al.
The mechanisms underlying how adrenocortical carcinoma (ACC) progresses into a metastatic and lethal disease remain poorly understood. To address this, we performed comprehensive genomic analyses to delineate the evolutionary trajectory of ...
Three-Tier Prognostic Stratification of Lung Carcinoids (NET G1-G2-G3) by Multivariable, Data-Driven Integration of Ki-67 and Mitotic Count [0.03%]
基于Ki-67和有丝分裂计数的多变量、数据驱动型整合的肺类癌(G1-G2-G3)三期预后分层
Giulia Orlando,Valentina Veronesi,Eleonora Duregon et al.
Giulia Orlando et al.
Pulmonary neuroendocrine tumors (NETs) include typical and atypical carcinoids, corresponding to low- and intermediate-grade malignancies. Integration of necrosis, mitotic count per 2 mm² (MC), and Ki-67 index, a desirable criterion in the...