Impact of Tissue Thickness on Computational Quantification of Features in Whole Slide Images for Diagnostic Pathology [0.03%]
组织厚度对全片数字病理图像量化特征计算的影响研究
Manav Shah,António Polónia,Mónica Curado et al.
Manav Shah et al.
Tissue section thickness (TST) is an understudied variable in digital pathology that significantly impacts both visual assessments and computational analyses. This study systematically examines the effects of TST on whole slide images (WSIs...
DLL3 Expression in Neuroendocrine Carcinomas and Neuroendocrine Tumours: Insights From a Multicentric Cohort of 1294 Pulmonary and Extrapulmonary Neuroendocrine Neoplasms [0.03%]
神经内分泌癌和神经内分泌肿瘤中的DLL3表达：来自1294例肺源性和肺外神经内分泌肿瘤的多中心队列研究
Maxime Schmitt,Hanibal Bohnenberger,Detlef Klaus Bartsch et al.
Maxime Schmitt et al.
Delta-like ligand 3 (DLL3) is frequently expressed in pulmonary small cell neuroendocrine carcinoma (SCNEC) and has emerged as a promising therapeutic target. However, limited data on DLL3 expression in other neuroendocrine neoplasms (NEN),...
Multicenter Study
Endocrine pathology. 2025 Mar 28;36(1):9. DOI:10.1007/s12022-025-09854-3 2025
Next-Generation Immunohistochemistry in Thyroid Neoplasm: A Practical Review on the Applications in Diagnosis and Molecular Classification [0.03%]
甲状腺肿瘤中下一代免疫组化：在诊断和分子分类中的应用的实际回顾
Jonathan P Rivera,Jen-Fan Hang
Jonathan P Rivera
An integrative histologic and molecular classification of thyroid tumors has become clinically relevant due to the potential role in risk stratification and selection of targeted therapy. In this review, we discuss the applications of six "...
Refining NTRK Fusion Detection in Papillary Thyroid Carcinoma Through Pan-TRK Immunohistochemistry and Histopathologic Features [0.03%]
通过泛TRK免疫组化和组织病理学特征改进乳头状甲状腺癌中NTRK融合检测
Hyun Lee,Sue Youn Kim,Ji Min Park et al.
Hyun Lee et al.
NTRK fusions are rare but recurrent driver alterations in papillary thyroid carcinoma (PTC), with therapeutic significance due to the availability of targeted TRK inhibitors. Pan-TRK immunohistochemistry (IHC) provides a practical approach ...
Methylation Profiles Differ According to Clinical Characteristics in Well-Differentiated Neuroendocrine Tumors of the Lung [0.03%]
肺部高度分化的神经内分泌肿瘤的甲基化谱型根据临床特征不同而不同
Philipp Melhorn,Erwin Tomasich,Alissa Blessing et al.
Philipp Melhorn et al.
Neuroendocrine tumors (NET) of the lung constitute a rare entity of primary lung malignancies that often exhibit an indolent clinical course. Epigenetics-related differences have been described previously for lung NET, but the clinical sign...
Comprehensive Gene Expression Analysis in Papillary Thyroid Carcinoma Reveals a Transcriptional Profile Associated with Reduced Radioiodine Avidity [0.03%]
乳头状甲状腺癌的综合基因表达分析揭示了与降低的放射性碘亲和力相关的转录谱
Vincenzo Condello,Carlotta Marchettini,Catharina Ihre-Lundgren et al.
Vincenzo Condello et al.
Papillary thyroid carcinoma (PTC) is the most common form of well-differentiated thyroid cancer (WDTC) and generally has a favorable prognosis. However, subsets of these tumors can metastasize, leading to aggressive disease progression and ...
Identification of Oncogenic Alterations in 124 Cases of Pediatric Papillary Thyroid Carcinoma: BEND7::ALK, DLG5::RET, and CCDC30::ROS1 Fusions Induce MAPK Pathway Activation [0.03%]
儿科乳头状甲状腺癌中124例致癌改变的鉴定：BEND7::ALK，DLG5::RET和CCDC30::ROS1融合诱导MAPK通路激活
Yixuan Liu,Longnv Bao,Guangqi Li et al.
Yixuan Liu et al.
Pediatric papillary thyroid carcinoma (PPTC; under age 18 at the time of diagnosis) is relatively uncommon. There are few studies concerning the genetic background of PPTC in Asian countries. In this study, we reviewed 124 cases of PPTC fro...
Clinical Relevance of ATRX/DAXX Gene Mutations and ALT in Functioning Pancreatic Neuroendocrine Tumors [0.03%]
ATRX / DAXX基因突变和ALT在功能性胰腺神经内分泌肿瘤中的临床相关性
Brenna R van T Veld,Wenzel M Hackeng,Claudio Luchini et al.
Brenna R van T Veld et al.
Functioning pancreatic neuroendocrine tumors (PanNETs) represent a subset of PanNETs that cause symptoms due to hormonal activity. Insulinoma is the most common functioning PanNET type. Mutations in the alpha thalassemia/mental retardation ...
Deep Learning Enabled Scoring of Pancreatic Neuroendocrine Tumors Based on Cancer Infiltration Patterns [0.03%]
基于癌症浸润模式的深度学习赋能胰腺神经内分泌肿瘤评分系统
Soner Koc,Ozgur Can Eren,Rohat Esmer et al.
Soner Koc et al.
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms that include tumors with different histomorphologic characteristics that can be correlated to sub-categories with different prognoses. In addition to the WHO ...
Evaluating CK20 and MCPyV Antibody Clones in Diagnosing Merkel Cell Carcinoma [0.03%]
评估CK20和MCPyV抗体克隆在诊断 Merkel 细胞癌中的作用
Begum Yeni Erdem,Can Baykal,Yasemin Ozluk et al.
Begum Yeni Erdem et al.
Merkel cell carcinoma (MCC) is diagnosed through histopathological and immunohistochemical examination of biopsies from skin or other organs. Its distinguishing features include perinuclear dot-like staining with Cytokeratin 20 (CK20) and d...