Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy [0.03%]
烷化剂化疗后免疫治疗高突变负荷和错配修复异常的转移性胰腺神经内分泌肿瘤
Louis de Mestier,Thorvardur R Halfdanarson,Leonidas Apostolidis et al.
Louis de Mestier et al.
Alkylating agent-based chemotherapy is one of the main treatment options for patients with metastatic pancreatic neuroendocrine tumors (PanNETs).However, it favors the acquisition of a hypermutator phenotype, suggesting a potential benefit ...
Correction to: TERT Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival [0.03%]
Correction to: TERT扩增是乳头状甲状腺癌的风险分层标志物，与肿瘤复发和生存显著相关
Sara Gil-Bernabé,Noa Feás-Rodríguez,Enrique Pérez-Riesgo et al.
Sara Gil-Bernabé et al.
Published Erratum
Endocrine pathology. 2025 Oct 30;36(1):41. DOI:10.1007/s12022-025-09881-0 2025
Performance of Immunohistochemistry to Detect Rb/p53 Alterations in High-Grade Neuroendocrine Neoplasms: Staining Patterns and Comparison with Genetic Testing [0.03%]
免疫组化检测高级别神经内分泌肿瘤Rb/p53异常的效能：染色模式及与基因检测结果对比分析
Ruiqian Chen,Matthieu Tihy,Ludovic Lacroix et al.
Ruiqian Chen et al.
Rb and p53 status helps distinguishing well from poorly differentiated high-grade neuroendocrine neoplasms (HG-NENs) and may predict response to platinum-based chemotherapy. Historically, gene and protein profile correlations for Rb and p53...
Comparative Study
Endocrine pathology. 2025 Oct 29;36(1):40. DOI:10.1007/s12022-025-09885-w 2025
Digital Immunophenotyping of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Subtypes With Specific Tumor-Immune Microenvironment Features [0.03%]
数字免疫分型鉴定出三种不同肿瘤-免疫微环境特征的肺不典型类癌和大细胞神经内分泌癌
Giovanni Centonze,Patrick Maisonneuve,Émilie Mathian et al.
Giovanni Centonze et al.
Atypical carcinoids (ACs) and large cell neuroendocrine carcinomas (LCNECs) are defined by the WHO as intermediate- and high-grade lung neuroendocrine neoplasms, respectively, based on morphological criteria; however, treatment strategies r...
Correction: Presurgical Succinate MetAstatic Risk Tool (P-SMART) in Paragangliomas [0.03%]
关于 presurgical succinate metabolic risk tool (P-SMART) 在副神经节瘤中的矫正意见
Elena Rapizzi,Lorenzo Zanatta,Alice Santi et al.
Elena Rapizzi et al.
Published Erratum
Endocrine pathology. 2025 Oct 22;36(1):37. DOI:10.1007/s12022-025-09884-x 2025
High Prevalence of Potential Molecular Therapeutic Targets in Poorly Differentiated Thyroid Carcinoma [0.03%]
分化型甲状腺癌中潜在分子治疗靶点的高流行率
Vanessa Zambelli,Giulia Orlando,Marta Fornaro et al.
Vanessa Zambelli et al.
Poorly differentiated thyroid carcinoma (PDTC) is a rare thyroid cancer with aggressive clinical course and peculiar clinical/pathological characteristics but lacking effective therapeutic options, when surgery is not curative. We aimed at ...
Intratumoral Heterogeneity of Ki67 Index and Its Impact on the Diagnosis and Prognostication of Pancreatic Neuroendocrine Tumors: Hot-Spot Count Differs Significantly from Random-Area Count [0.03%]
胰腺神经内分泌肿瘤中Ki67指数的瘤内异质性及其对诊断和预后的影响：热点计数与随机区域计数显著不同
Ozgur Can Eren,Nobuyuki Ohike,Deniz Tuncel et al.
Ozgur Can Eren et al.
The pivotal role of Ki67 in grading pancreatic neuroendocrine tumors (PanNETs) is well recognized and firmly established in current WHO guidelines. Intratumoral heterogeneity is a well-known phenomenon, and it has also been documented for K...
Pituitary Neuroendocrine Tumor or Pituitary Adenoma? Let's Ask the Epigenome! [0.03%]
垂体神经内分泌肿瘤还是垂体腺瘤？让我们来问问表观基因组吧！
Matthias Dottermusch
Matthias Dottermusch
The introduction of the term pituitary neuroendocrine tumor (PitNET) to replace pituitary adenoma has sparked a versatile debate among experts. The controversy surrounding this nomenclature change includes the question of whether these tumo...
Meta-Analysis
Endocrine pathology. 2025 Oct 8;36(1):35. DOI:10.1007/s12022-025-09879-8 2025
MiThyCA: A Computational Pathology Pipeline for the Identification of Microscopic Foci of Papillary Thyroid Carcinoma-Like Nuclear Features with AI in Whole-Slide Histological Images [0.03%]
基于人工智能的用于识别全片组织学图像中乳头状甲状腺癌样核特征微焦点的计算病理学流程MiThyCA
Leone Bacciu,Mario Urso,Vasco Coelho et al.
Leone Bacciu et al.
The histological identification of papillary thyroid carcinoma (PTC) is straightforward for experienced endocrine pathologists. The increase in radical thyroidectomies led to a raise in the rate of postoperative incidental subcentimeter PTC...
Presurgical Succinate MetAstatic Risk Tool (P-SMART) in Paragangliomas [0.03%]
术前琥珀酸代谢物风险评估工具(P-SMART)在副神经节瘤中的应用
Elena Rapizzi,Lorenzo Zanatta,Alice Santi et al.
Elena Rapizzi et al.
Introduction: Paragangliomas (PGLs) are rare malignant non-epithelial neuroendocrine neoplasms characterized by a strong genetic determinism and heterogeneous metastatic potential with no reliable histopathological predic...