SATB2 is an Emergent Biomarker of Anaplastic Thyroid Carcinoma: A Series with Comprehensive Biomarker and Molecular Studies [0.03%]
SATB2是未分化甲状腺癌新兴生物标志物：具有全面生物标志物和分子研究的系列文章
Dingani Nkosi,William E Crowe,Brian J Altman et al.
Dingani Nkosi et al.
Anaplastic thyroid carcinoma (ATC) is a rare and aggressive thyroid malignancy typically comprised of undifferentiated tumor cells with various histologic morphologies, which makes the diagnosis challenging. These tumors commonly show loss ...
Mitochondrial Proteome Defined Molecular Pathological Characteristics of Oncocytic Thyroid Tumors [0.03%]
线粒体蛋白质组定义了甲状腺肿瘤的分子病理特征
Lu Li,Likun Zhang,Wenhao Jiang et al.
Lu Li et al.
Oncocytic thyroid tumors are characterized by an elevated mitochondrial density within the cells, distinguishing them from other thyroid tumors, exhibit distinct clinical behaviors, including increased invasiveness and iodine therapy resist...
Unravelling the Reasons Behind Limited Response to Anti-PD Therapy in ATC: A Comprehensive Evaluation of Tumor-Infiltrating Immune Cells and Checkpoints [0.03%]
解开anti-PD疗法在ATC中反应有限的原因：对肿瘤浸润性免疫细胞和检查点的全面评估
Monikongkona Boruah,Shipra Agarwal,Riyaz Ahmad Mir et al.
Monikongkona Boruah et al.
Inhibiting the immune checkpoint (ICP) PD-1 based on PD-L1 expression status has revolutionized the treatment of various cancers, yet its efficacy in anaplastic thyroid carcinoma (ATC) remains limited. The therapeutic response depends upon ...
The Molecular Classification of Pheochromocytomas and Paragangliomas: Discovering the Genomic and Immune Landscape of Metastatic Disease [0.03%]
pheo和paragan的分子分型：探索转移性疾病中的基因组及免疫图谱
Carolijn J M de Bresser,Ronald R de Krijger
Carolijn J M de Bresser
Pheochromocytomas (PCCs) and paragangliomas (PGLs, together PPGLs) are the most hereditary tumors known. PPGLs were considered benign, but the fourth edition of the World Health Organisation (WHO) classification redefined all PPGLs as malig...
High-Grade Progression, Sarcomatous Transformation, and/or Metastasis of Pituitary Neuroendocrine Neoplasms (PitNENs): The UCSF Experience [0.03%]
高分级进展、肉瘤样转化和/或转移性垂体神经内分泌肿瘤（PitNEN）的UCSF经验
Merryl Terry,Minh P Nguyen,Vivian Tang et al.
Merryl Terry et al.
Pituitary neuroendocrine tumors (PitNET) that metastasize comprise ~ 0.2% of adenohypophyseal tumors are aggressive and are challenging to treat. However, many non-metastatic tumors are also aggressive. Herein, we review 21 specimens from 1...
Rapid Evolution of Metastases in Patients with Treated G3 Neuroendocrine Tumors Associated with NEC-Like Transformation and TP53 Mutation [0.03%]
G3神经内分泌肿瘤患者的转移灶快速演变与小细胞神经内分泌癌样转化和TP53突变相关性研究
Atsuko Kasajima,Nicole Pfarr,Eva-Maria Mayr et al.
Atsuko Kasajima et al.
Little is known about the morphomolecular features of G3 neuroendocrine tumors (G3NETs) under prolonged systemic treatments, although rapid progression is increasingly observed. This longitudinal study aims to elucidate the course and morph...
Catching the Silent Culprits: TERT Promoter Mutation Screening of Minimally Invasive Follicular and Oncocytic Thyroid Carcinoma in Clinical Practice [0.03%]
沉默的罪魁祸首：临床实践中微创滤泡性和乳头状甲状腺癌TERT启动子突变筛查
L Samuel Hellgren,Adam Stenman,Kenbugul Jatta et al.
L Samuel Hellgren et al.
De-escalation of thyroid cancer treatment is crucial to prevent overtreatment of indolent disease, but it remains important to identify clinically aggressive cases. TERT promoter mutations are molecular events frequently associated with hig...
Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres) [0.03%]
产生胰高糖素的神经内分泌肿瘤（胰高糖素瘤）富含ARX和PDX1共表达、DAXX/ATRX突变和ALT（端粒异常延长）的侵袭性肿瘤
Paola Mattiolo,Michele Bevere,Andrea Mafficini et al.
Paola Mattiolo et al.
Glucagonomas are functioning pancreatic neuroendocrine tumors (PanNETs) responsible for glucagonoma syndrome. This study aims to shed light on the clinicopathological and molecular features of these neoplasms. Six patients with glucagonomas...
Novel Drop-off PCR Assay for USP8 Hotspot Variant Detection in Corticotroph Tumors [0.03%]
一种新型PCR测定方法用于库欣病促肾上腺皮质激素分泌肿瘤中USP8热点突变的检测
Renan Lyra Miranda,Alexandro Guterres,Carlos Henrique de Azeredo Lima et al.
Renan Lyra Miranda et al.
Somatic Molecular Heterogeneity in Bilateral Macronodular Adrenocortical Disease (BMAD) Differs Among the Pathological Subgroups [0.03%]
双侧肾上腺大结节病(BMAD)病理亚组的体细胞分子异质性不同
Florian Violon,Lucas Bouys,Patricia Vaduva et al.
Florian Violon et al.
Bilateral macronodular adrenocortical disease (BMAD) is an uncommon cause of Cushing's syndrome leading to bilateral macronodules. Isolated BMAD has been classified into three molecular groups: patients with ARMC5 alteration, KDM1A alterati...