68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer [0.03%]
68镓-MY6349 PET/CT成像评估多种类型肿瘤TROP2表达水平
Haojun Chen,Liang Zhao,Yizhen Pang et al.
Haojun Chen et al.
BACKGROUNDConsidering that trophoblast cell-surface antigen 2 (Trop2) is overexpressed in a wide range of human epithelial cancers, it presents an attractive target for diagnosis and treatment of multiple types of cancer. Herein, we have de...
Eric Tran
Eric Tran
Treatment with T cells genetically engineered to express tumor-reactive T cell receptors (TCRs), known as TCR-gene therapy (TCR-T), is a promising immunotherapeutic approach for patients with cancer. The identification of optimal TCRs to us...
Experimental West Nile virus infection provides lessons for recovery from enteric neuropathies [0.03%]
实验性西尼罗病毒感染提供了肠道神经病恢复的启示
Joel C Bornstein
Joel C Bornstein
Loss of enteric neurons leading to long-term gastrointestinal dysfunction is common to many diseases, and the path to functional recovery is unclear. In this issue of the JCI, Janova et al. report that West Nile virus killed enteric neurons...
Targeting TET3 in macrophages provides a concept strategy for the treatment of endometriosis [0.03%]
靶向定位巨噬细胞TET3为治疗子宫内膜异位症提供了一个新策略
Hossein Hosseinirad,Md Saidur Rahman,Jae-Wook Jeong
Hossein Hosseinirad
Endometriosis, characterized by the presence of endometrial-like tissue outside the uterus, is a condition associated with pain and infertility. In this issue of the JCI, Lv et al. illuminate the critical pathophysiological role of the ten-...
Accumulation of Epstein-Barr virus-induced cross-reactive immune responses is associated with multiple sclerosis [0.03%]
Epstein-Barr病毒引起的交叉免疫反应的积累与多发性硬化相关
Hannes Vietzen,Laura M Kühner,Sarah M Berger et al.
Hannes Vietzen et al.
The convergence of genomic medicine and translational omics in transforming breast cancer patient care [0.03%]
基因组医学和转化组学在乳腺癌患者护理中的融合与转变
Sulin Wu,Yonglan Zheng,Olufunmilayo I Olopade
Sulin Wu
Kelsey R van Straalen,Vincent Piguet,Johann E Gudjonsson
Kelsey R van Straalen
Enhanced susceptibility of pediatric airway epithelium to respiratory syncytial virus infection [0.03%]
呼吸道合胞病毒感染下小儿气道上皮易感性增强
Raymond J Pickles,Gang Chen,Scott H Randell
Raymond J Pickles
Immature innate and adaptive immunity and vulnerability of narrower airways to obstruction increase the susceptibility of infants to severe respiratory syncytial virus (RSV) disease. In this issue of the JCI, Zhao et al. illustrated greater...
Activation of STAT3-mediated ciliated cell survival protects against severe infection by respiratory syncytial virus [0.03%]
活化的STAT3介导的纤毛细胞生存可保护呼吸道合胞病毒引起的严重感染
Caiqi Zhao,Yan Bai,Wei Wang et al.
Caiqi Zhao et al.
Respiratory syncytial virus (RSV) selectively targets ciliated cells in human bronchial epithelium and can cause bronchiolitis and pneumonia, mostly in infants. To identify molecular targets of intervention during RSV infection in infants, ...
Laura J Rasmussen-Torvik
Laura J Rasmussen-Torvik