Rapid response of lichen planus to baricitinib associated with suppression of cytotoxic CXCL13+ CD8+ T-cells [0.03%]
巴瑞克替尼快速缓解扁平苔藓与细胞毒性CXCL13+CD8+T细胞抑制相关
Angelina S Hwang,Jacob A Kechter,Tran H Do et al.
Angelina S Hwang et al.
Background: Cutaneous lichen planus (LP) is a recalcitrant, difficult-to-treat, inflammatory skin disease characterized by pruritic, flat-topped, violaceous papules on the skin. Baricitinib is an oral Janus kinase (JAK) 1...
Single-nuclei transcriptomics reveals TBX5-dependent targets in a patient with Holt-Oram syndrome [0.03%]
单核转录组学揭示HO Syndrome患者TBX5依赖性靶点
Jeffrey D Steimle,Yi Zhao,Fansen Meng et al.
Jeffrey D Steimle et al.
Complement-producing maternal microchimeric cells override infection susceptibility in complement-deficient murine offspring [0.03%]
补体缺乏型小鼠后代中母源性微嵌合细胞产生补体而不再易患感染性疾病
Giang Pham,Raymond E Diep,Lucien H Turner et al.
Giang Pham et al.
MAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer [0.03%]
MAP3K1突变使激素受体阳性HER2阴性乳腺癌产生肿瘤免疫异质性
Yuwen Cai,Cui-Cui Liu,Yanwu Zhang et al.
Yuwen Cai et al.
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer, the most common type of breast cancer, is facing challenges such as endocrine therapy resistance and distant relapse. Immunotherapy has...
Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging [0.03%]
烟酸和吡哆醇可刺激肌肉干细胞增殖并增强衰老期间的再生能力
Sara Ancel,Joris Michaud,Eugenia Migliavacca et al.
Sara Ancel et al.
Skeletal muscle relies on resident muscle stem cells (MuSCs) for growth and repair. Aging and muscle diseases impair MuSC function, leading to stem cell exhaustion and regenerative decline that contribute to the progressive loss of skeletal...
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice [0.03%]
克隆性造血小鼠模型中炎症交叉 talk损害吞噬受体并加重动脉粥样硬化病情
Wenli Liu,Brian D Hardaway,Eunyoung Kim et al.
Wenli Liu et al.
Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis, but the mechanisms by which CH mutant cells transmit inflammatory signals to nonmutant cells are largely unknown. To address this question, we transplanted 1.5% Jak2V6...
In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions [0.03%]
宫内感染人巨细胞病毒可诱导产生NK样FcγRIII⁺CD8⁺T细胞并介导抗体效应功能
Eleanor C Semmes,Danielle R Nettere,Ashley N Nelson et al.
Eleanor C Semmes et al.
Human cytomegalovirus (HCMV) profoundly impacts host T and NK cells across the lifespan, yet how this common congenital infection modulates developing fetal immune cell compartments remains underexplored. Using cord blood from neonates with...
Prospective observational study and mechanistic evidence showing lipolysis of circulating triglycerides worsens hypertriglyceridemic acute pancreatitis [0.03%]
前瞻性队列研究和机制证据显示循环三酰甘油的脂解恶化以高三酰甘油血症为特征的急性胰腺炎
Prasad Rajalingamgari,Biswajit Khatua,Megan J Summers et al.
Prasad Rajalingamgari et al.
BACKGROUNDWhile most hypertriglyceridemia is asymptomatic, hypertriglyceridemia-associated acute pancreatitis (HTG-AP) can be more severe than AP of other etiologies. The reasons underlying this are unclear. We thus examined whether lipolyt...
Progranulin-dependent repair function of Regulatory T cells drive bone fracture healing [0.03%]
脯氨酸丰富的分泌型蛋白质在调节性T细胞中的功能对于骨折愈合至关重要
Ruiying Chen,Xiaomeng Zhang,Bin Li et al.
Ruiying Chen et al.
Local immunoinflammatory events instruct skeletal stem cells (SSCs) to repair/regenerate bone after injury, but mechanisms are incompletely understood. We hypothesized that specialized Regulatory T (Treg) cells are necessary for bone repair...
Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats [0.03%]
melanocortin-4受体拮抗剂TCMCB07可缓解大鼠化疗引起的厌食和体重减轻
Xinxia Zhu,Russell Potterfield,Kenneth A Gruber et al.
Xinxia Zhu et al.
Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance and quality of life, and worsens oncologic outcomes. There are currently few effec...