Cell-cycle machinery is critical in regulating uterine steroid hormone for embryo implantation and development [0.03%]
细胞周期机制在调节子宫类固醇激素以实现胚胎植入和发育方面发挥关键作用
Francesco J DeMayo
Francesco J DeMayo
Proper embryo implantation is necessary for a successful pregnancy. In this issue of the JCI, Aljubran et al. identified the cell cycle regulatory protein cyclin A2 (CCNA2) as a factor in supporting embryo implantation and embryo developmen...
Nuclear PD-L1 compartmentalization suppresses tumorigenesis and overcomes immunocheckpoint therapy resistance in mice via histone macroH2A1 [0.03%]
核内PD-L1区隔化通过组蛋白macroH2A1在小鼠中抑制肿瘤发生并克服免疫检查点治疗抗性
Yong Liu,Zhi Yang,Shuanglian Wang et al.
Yong Liu et al.
Canonically PD-L1 functions as the inhibitory immune checkpoint on cell surface. Recent studies have observed PD-L1 expression in the nucleus of cancer cells. But the biological function of nuclear PD-L1 (nPD-L1) in tumor growth and antitum...
Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation [0.03%]
乳酸通过CBX3调控的组蛋白乳酸化重编程胶质母细胞瘤免疫反应
Shuai Wang,Tengfei Huang,Qiulian Wu et al.
Shuai Wang et al.
Glioblastoma (GBM), an aggressive brain malignancy with a cellular hierarchy dominated by GBM stem cells (GSCs), evades antitumor immunity through mechanisms that remain incompletely understood. Like most cancers, GBMs undergo metabolic rep...
It takes a village [0.03%]
养育孩子需要全村人的努力
Alex D Waldman
Alex D Waldman
Transparency, bias, and reproducibility across science: a meta-research view [0.03%]
(meta)研究视角下的科学研究透明性、偏倚和可重复性
John Pa Ioannidis
John Pa Ioannidis
N/A.
Parkin paves the path to antitumor immunity: Expanding Parkin's role as a tumor suppressor [0.03%]
Parkin促进抗肿瘤免疫：扩大Parkin的抑癌蛋白作用
Hyungsoo Kim,Ze&#x;ev A Ronai
Hyungsoo Kim
Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppress...
Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles [0.03%]
减数分裂I期缺陷有助于雄性合子型葡萄胎的产生
Maryam Rezaei,Manqi Liang,Zeynep Yalcin et al.
Maryam Rezaei et al.
To identify novel genes responsible for recurrent hydatidiform moles (HMs), we performed exome sequencing on 75 unrelated patients who were negative for mutations in the known genes. We identified biallelic deleterious variants in 6 genes, ...
Shuyan Tang,Ting Guo,Chengcheng Song et al.
Shuyan Tang et al.
Although premature ovarian insufficiency (POI), a common cause of female infertility and subfertility, has a well-established hereditary component, the genetic factors currently implicated in POI account for only a limited proportion of cas...
Xylazine induces dopamine release and augments the effects of fentanyl [0.03%]
丁丙诺啡诱发多巴胺释放并增强喷他佐辛的作用
Joseph R Trinko,Ethan Foscue,Edward M Kong et al.
Joseph R Trinko et al.
Rg3-lipo biomimetic delivery of paclitaxel enhances targeting of tumors and myeloid-derived suppressor cells [0.03%]
RG3-脂肽模拟递送系统可增强白蛋白紫杉醇对肿瘤组织及髓源抑制细胞的靶向作用
Yuru Shen,Bin Zhong,Wanwei Zheng et al.
Yuru Shen et al.
Liposomal drug delivery systems have revolutionized traditional cytotoxic drugs. However, the relative instability and toxicity of the existing liposomal drug delivery systems compromised their efficacy. Herein, we present Rg3-lipo, an inno...