Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition [0.03%]
肿瘤细胞源精胺通过抑制CD8+t细胞促进胶质母细胞瘤的免疫微环境恶化
Kristen E Kay,Juyeun Lee,Ellen S Hong et al.
Kristen E Kay et al.
The glioblastoma (GBM) microenvironment is enriched in immunosuppressive factors that potently interfere with the function of cytotoxic T lymphocytes. Cancer cells can directly impact the immune system, but the mechanisms driving these inte...
An inducible RIPK3-driven necroptotic system enhances cancer cell-based immunotherapy and ensures safety [0.03%]
诱导型RIPK3凋亡系统增强基于免疫疗法的癌症治疗并确保其安全性
Kok-Siong Chen,Sarah Manoury-Battais,Nobuhiko Kanaya et al.
Kok-Siong Chen et al.
Recent progress in cancer cell-based therapies has led to effective targeting and robust immune responses against cancer. However, the inherent safety risks of using live cancer cells necessitate the creation of an optimized safety switch w...
Low tristetraprolin expression activates phenotypic plasticity and primes transition to lethal prostate cancer in mice [0.03%]
低四聚泛素结合蛋白TRIM21通过激活表型可塑性来促进小鼠致死性前列腺癌的发展
Katherine L Morel,Beatriz Germán,Anis A Hamid et al.
Katherine L Morel et al.
Phenotypic plasticity is a hallmark of cancer and increasingly realized as a mechanism of resistance to androgen receptor (AR)-targeted therapy. Now that many prostate cancer (PCa) patients are treated upfront with AR-targeted agents, it's ...
G-CSF resistance of ELANE mutant neutropenia depends on SERF1 containing truncated neutrophil elastase aggregates [0.03%]
ELANE突变性中性粒细胞减少症的G-CSF抵抗与SERF1介导的截短型中性粒弹性蛋白酶聚集体有关
Ramesh C Nayak,Sana Emberesh,Lisa Trump et al.
Ramesh C Nayak et al.
Severe congenital neutropenia (SCN) is frequently associated with dominant point mutations in ELANE, the gene encoding neutrophil elastase (NE). Chronic administration of granulocyte colony-stimulating factor (G-CSF) is a first-line treatme...
David Ginsburg
David Ginsburg
The lung is a megakaryocyte outpost that can defend against thrombocytopenic attack [0.03%]
肺是巨核细胞前哨站可防御血小板减少攻击
Anthony K Yeung,George J Murphy
Anthony K Yeung
Lung megakaryocytes (Mks) are a unique subset of Mks that are distinct from their bone marrow counterparts. Recent evidence suggests that lung Mks favor an immune phenotype, but have unclear contributions to the total platelet mass. In this...
Insulin-like growth factor 2 drives fibroblast-mediated tumor immunoevasion and confers resistance to immunotherapy [0.03%]
胰岛素样生长因子2驱动成纤维细胞介导的肿瘤免疫逃避并赋予免疫疗法耐药性
Daqiang Song,Yushen Wu,Jie Li et al.
Daqiang Song et al.
T cell exclusion is crucial in enabling tumor immune evasion and immunotherapy resistance. However, the key genes driving this process remain unclear. We uncovered a notable increase of insulin-like growth factor 2 (IGF2) in immune-excluded...
CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia [0.03%]
幼稚颗粒细胞分泌的CXCL8通过抑制野生型造血抑制慢性嗜酸性粒细胞性白血病中的野生型造血功能
Paul Deschamps,Margaux Wacheux,Axel Gosseye et al.
Paul Deschamps et al.
Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy with limited therapeutic options. Single-cell analysis of clonal architecture demonstrates early clonal dominance with few residual WT hematopoietic stem cells. Circulati...
Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis [0.03%]
诱导性CCR2+非经典单核细胞介导癌症转移的消退
Xianpeng Liu,Ziyou Ren,Can Tan et al.
Xianpeng Liu et al.
A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for the promotion of m...