A large-scale population-based study reveals that gp42-IgG antibody is protective against Epstein-Barr virus-associated nasopharyngeal carcinoma [0.03%]
一项大规模人群队列研究发现gp42-IgG抗体可保护免于罹患EB病毒相关鼻咽癌
Xiang-Wei Kong,Guo-Long Bu,Hua Chen et al.
Xiang-Wei Kong et al.
Background: Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC), but the existence of NPC protective antibody against EBV-associated antigens remains inconclusive. ...
AAV9/SLC6A1 gene therapy rescues abnormal EEG patterns and cognitive behavioral deficiencies in Slc6a1-/- mice [0.03%]
AAV9/Slc6a1基因治疗可改善Slc6a1-/ -小鼠的异常脑电图及行为缺陷
Weirui Guo,Matthew Rioux,Frances Shaffo et al.
Weirui Guo et al.
The SLC6A1 gene encodes the gamma-aminobutyric acid (GABA) transporter GAT-1, the deficiency of which is associated with infantile encephalopathy with intellectual disability. We designed two AAV9 vectors, with either the JeT or MeP promote...
Ferumoxytol nanozymes effectively target chronic biofilm infections in apical periodontitis [0.03%]
纳米酶富马氧化铁有效针对牙周根尖慢性生物被膜感染
Alaa Babeer,Yuan Liu,Zhi Ren et al.
Alaa Babeer et al.
Bacterial biofilms are pervasive and recalcitrant to current antimicrobials, causing numerous infections. Iron oxide-nanozymes, including an FDA-approved formulation (ferumoxytol, FMX), show potential against biofilm infections via catalyti...
Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model [0.03%]
自身抗原塑造了自发性类风湿关节炎小鼠模型中的转录组和TCR库
Elizabeth E McCarthy,Steven Yu,Noah Perlmutter et al.
Elizabeth E McCarthy et al.
The development of pathogenic autoreactive CD4+ T cells, particularly in the context of impaired signaling, remains poorly understood. Unraveling how defective signaling pathways contribute to their activation and persistence is crucial for...
IL-2-inducible T cell kinase deficiency sustains chimeric antigen receptor T cell therapy against tumor cells [0.03%]
诱导T细胞激酶缺乏维持针对肿瘤细胞的嵌合抗原受体T细胞治疗
Zheng Fu,Zineng Huang,Hao Xu et al.
Zheng Fu et al.
Despite the revolutionary achievements of chimeric antigen receptor (CAR) T cell therapy in treating cancers, especially leukemia, several key challenges still limit its therapeutic efficacy. Of particular relevance is the relapse of cancer...
Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV [0.03%]
靶向SARS-CoV刺突糖蛋白稀有抗原位点的人源单克隆抗体的结构表征
Naveenchandra Suryadevara,Nurgun Kose,Sandhya Bangaru et al.
Naveenchandra Suryadevara et al.
The function of the spike protein N terminal domain (NTD) in coronavirus (CoV) infections is poorly understood. However, some rare antibodies that target the SARS-CoV-2 NTD potently neutralize the virus. This finding suggests the NTD may co...
Elevated microRNA-187 causes cardiac endothelial dysplasia to promote congenital heart disease through inhibition of NIPBL [0.03%]
微小核糖核酸-187通过抑制分离起始蛋白NIPBL诱发心内膜发育不良促进先天性心脏病发生发展中文标题
Chao Li,Zizheng Tan,Hongdou Li et al.
Chao Li et al.
Cardiac endothelial cells are essential for heart development, and disruption of this process can lead to congenital heart disease (CHD). However, how microRNAs influence cardiac endothelial cells in CHD remains unclear. This study identifi...
Neisseria gonorrhoeae induces local secretion of IL-10 at the human cervix to promote colonization [0.03%]
淋球菌通过局部诱导宫颈分泌IL-10来促进定殖
Yiwei Dai,Vonetta L Edwards,Qian Yu et al.
Yiwei Dai et al.
Gonorrhea, caused by the human-restricted pathogen Neisseria gonorrhoeae, is a commonly reported sexually transmitted infection. Since most infections in women are asymptomatic, the true number of infections is likely much higher than repor...
Mutations in unfolded protein response regulator ATF6 cause hearing and vision loss syndrome [0.03%]
ATF6突变引起未折叠蛋白反应异常导致感觉神经性聋盲综合征
Eun-Jin Lee,Kyle Kim,Monica Sophia Diaz-Aguilar et al.
Eun-Jin Lee et al.
Activating transcription factor 6 (Atf6) is a key regulator of the unfolded protein response (UPR) and is important for endoplasmic reticulum (ER) function and protein homeostasis in metazoan cells. Patients carrying loss-of-function ATF6 d...
Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease [0.03%]
特异性皮肤上皮细胞的铁死亡启动并维持慢性全身免疫介导的银屑病
Kavita Vats,Hua Tian,Kunal Singh et al.
Kavita Vats et al.
Dysregulations of epithelial-immune interactions frequently culminate in chronic inflammatory diseases of the skin, lungs, kidneys, and gastrointestinal tract. Yet, the intraepithelial processes which initiate and perpetuate inflammation in...