Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice [0.03%]
胸腺白介素4减少可损害非肥胖糖尿病小鼠的负性T细胞选择功能
Alexis N Cattin-Roy,Kimberly G Laffey,Luan B Le et al.
Alexis N Cattin-Roy et al.
Type 1 diabetes (T1D) develops spontaneously despite functional antigen presentation machinery in the thymus and a perceptible central tolerance process. We found that intrathymic enrichment with IL-4 fine tunes signaling through the IL-4/I...
Sex, cells, and metabolism: Androgens temper Th17-mediated immunity [0.03%]
性、细胞和代谢：雄激素缓解Th17介导的免疫反应
Nikita L Mani,Samuel E Weinberg
Nikita L Mani
Sex-based differences in autoimmune disease susceptibility have long been recognized, prompting investigations into how sex hormones influence immunity. Recent advances suggest that hormones may shape immune responses by altering cellular m...
Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α [0.03%]
通过增强血红蛋白亲和力和抑制HIF-2α改善线粒体疾病的治疗性缺氧疗法
Hong Wang,Maria Miranda,Eizo Marutani et al.
Hong Wang et al.
HO-1 impairs the efficacy of radiotherapy by redistributing cGAS and STING in tumors [0.03%]
HO-1通过在肿瘤中重新分布cGAS和STING来影响放射治疗的效果
Chuqing Zhang,Zhenji Deng,Jiawei Wu et al.
Chuqing Zhang et al.
Type I IFNs (IFN-Is) induced by radiotherapy (RT) are critical for its efficacy, while the mechanism by which tumor cells inhibit IFN-I production remains largely unsolved. By an unbiased CRISPR screen, we identified hemeoxygenase 1 (HO-1) ...
Supportive care or exhausted neglect: the role of microglia at the end stage of prion disease [0.03%]
助力还是耗竭：微胶质细胞在朊病毒病终末期的作用
Victoria A Lawson
Victoria A Lawson
The transmissible nature of prion diseases enables reproduction of neurodegeneration in small animal models that faithfully follows the disease process observed in the natural disease of animals and humans. This allows the temporal developm...
Taking the STING out of radiotherapy: STING checkpoints mediate radiation resistance [0.03%]
去除放疗的STING作用：STING检查点介导辐射抵抗性
Michael C Brown,Justin T Low,Michelle L Bowie et al.
Michael C Brown et al.
The cyclic GMP-AMP synthase/stimulator of interferon genes (cGAS/STING) pathway is a critical driver of type I interferon (IFN-I) and antitumor CD8+ T cell responses after radiotherapy (RT). In this issue of the JCI, two reports describe me...
Palmitoylation acts as a checkpoint for MAVS aggregation to promote antiviral innate immune responses [0.03%]
棕榈酰化作用于MAVS聚集的检查点以促进抗病毒先天免疫反应
Liqiu Wang,Mengqiu Li,Guangyu Lian et al.
Liqiu Wang et al.
Upon RNA virus infection, the signaling adaptor MAVS forms functional prion-like aggregates on the mitochondrial outer membrane, which serve as a central hub that links virus recognition to downstream antiviral innate immune responses. Mult...
Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir [0.03%]
评估临床抗逆转录病毒治疗30年对HIV-1储存隔室的影响
Irene González-Navarro,Víctor Urrea,Cristina Gálvez et al.
Irene González-Navarro et al.
Background: Antiretroviral therapy (ART) has improved the clinical management of HIV-1 infection. However, little is known about how the latest ART recommendations affect the heterogeneity of HIV-1 reservoir size. ...
Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival [0.03%]
Beclin 1通过预防ISG15介导的细胞因子风暴来保障胎儿造血和存活
Wen Wei,Xueqin Gao,Jiawei Qian et al.
Wen Wei et al.
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is asso...
NEUROPILIN-1 INHIBITION SUPPRESSES NERVE-GROWTH FACTOR SIGNALING AND NOCICEPTION IN PAIN MODELS [0.03%]
神经纤毛蛋白-1抑制可阻断疼痛模型中的神经生长因子信号传导和痛觉异常
Chloe J Peach,Raquel Tonello,Elisa Damo et al.
Chloe J Peach et al.
Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain yet failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a co-receptor for NGF and tropomyosin-related ki...