A deep intronic mutation causes RAD50 deficiency through an unusual mechanism of distant exon activation [0.03%]
一个深部内含子突变通过激活远处外显子导致RAD50缺乏的异常机制
Kristine Bousset,Stefano Donega,Najim Ameziane et al.
Kristine Bousset et al.
Red Blood Cells Capture and Deliver Bacterial DNA to Drive Host Responses During Polymicrobial Sepsis [0.03%]
红细胞在多微生物败血症期间捕获并递送细菌DNA以驱动宿主反应
L K Metthew Lam,Nathan J Klingensmith,Layal Sayegh et al.
L K Metthew Lam et al.
Red blood cells (RBCs), traditionally recognized for their role in transporting oxygen, play a pivotal role in the body's immune response by expressing TLR9 and scavenging excess host cell-free DNA. DNA capture by RBCs leads to accelerated ...
Cathelicidin antimicrobial peptide expression in neutrophils and neurons antagonistically modulates neuroinflammation [0.03%]
中性粒细胞和神经元中的 Cathelicidin 抗微生物多肽表达拮抗调节神经炎症反应
Subash Chand Verma,Emmanuelle Enée,Kanchanadevi Manasse et al.
Subash Chand Verma et al.
Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS), the pathophysiology of which remains unclear and for which there is no definitive cure. Antimicrobial peptides (AMPs) are immunomodulatory molec...
Rares Drula,George A Calin
Rares Drula
Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells [0.03%]
核梭杆菌通过肿瘤干细胞新生促进结直肠癌的发展
Qinying Wang,Tingting Hu,Qinyuan Zhang et al.
Qinying Wang et al.
Intestinal stem cells are crucial for maintaining intestinal homeostasis, yet their transformation into tumor stem cells in the context of microbial infection remains poorly understood. Fusobacterium nucleatum (F. nucleatum) is frequently a...
C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models [0.03%]
一种新型钙通道阻断剂C2230选择性抑制CaV2.2通道，发挥多种痛觉模型的镇痛作用
Cheng Tang,Kimberly Gomez,Yan Chen et al.
Cheng Tang et al.
Antagonists (e.g., Ziconotide, Gabapentin) of the CaV2.2 (N-type) calcium channels are used clinically as analgesics for chronic pain. However, their use is limited by narrow therapeutic windows, difficult dosing routes (Ziconotide), misuse...
YAP1 induces bladder cancer progression and promotes immune evasion through IL-6/ STAT3 pathway and CXCL deregulation [0.03%]
YAP1通过IL-6/STAT3信号通路和CXCL异常调节诱导膀胱癌进展及免疫逃逸
Pritam Sadhukhan,Mingxiao Feng,Emily J Illingworth et al.
Pritam Sadhukhan et al.
The Hippo signaling pathway plays a key role in tumorigenesis in different cancer types. We investigated the role of the Hippo "effector" YAP1 on the tumor immune microenvironment (TIME) of urothelial carcinoma of bladder (UCB) and evaluate...
Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressure [0.03%]
血管平滑肌细胞PRDM16调控血压的昼夜节律变异
Zhenguo Wang,Wenjuan Mu,Juan Zhong et al.
Zhenguo Wang et al.
Disruptions of blood pressure (BP) circadian variation are closely associated with an increased risk of cardiovascular disease (CVD). Thus, gaining insights into the molecular mechanisms of BP circadian variation is essential for comprehend...
Post-ischemic inactivation of HIF Prolyl Hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis [0.03%]
缺血后诱导内皮细胞HIF脯氨酰羟化酶失活通过促进糖酵解导致肾小管上皮细胞适应不良修复反应
Ratnakar Tiwari,Rajni Sharma,Ganeshkumar Rajendran et al.
Ratnakar Tiwari et al.
Ischemic acute kidney injury (AKI) is common in hospitalized patients and increases the risk for chronic kidney disease (CKD). Impaired endothelial cell (EC) functions are thought to contribute in AKI to CKD transition, but the underlying m...
Dysregulated Treg repair responses lead to chronic rejection after heart transplantation [0.03%]
调节性T细胞修复反应失调导致心脏移植后的慢性排斥反应
Jordan Jp Warunek,Lu Fan,Xue Zhang et al.
Jordan Jp Warunek et al.
Chronic rejection (CR) after organ transplantation is alloimmune injury manifested by graft vascular remodeling and fibrosis that is resistant to immunosuppression. Single-cell RNA-Seq analysis of MHC class II-mismatched (MHCII-mismatched) ...