Immune-molecular interactions in high-grade serous ovarian cancer distinguish long-term survivors [0.03%]
高级别浆液性卵巢癌中免疫分子间的相互作用可区分长期生存者
Jeanette E Boudreau
Jeanette E Boudreau
The approach and efficacy of treatments for high-grade serous carcinoma (HGSC) of the ovary have changed little in decades. Although numerous studies demonstrated immune infiltration as frequent and prognostically beneficial, clinical trial...
Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs [0.03%]
免疫系统平衡：SHP1调控炎症肺中的中性粒细胞活化
Laxman Ghimire,Hongbo R Luo
Laxman Ghimire
Following respiratory infection or injury, neutrophil hyperactivation can damage surrounding lung tissue by releasing harmful compounds. In this issue of the JCI, Moussavi-Harami and colleagues identified tyrosine phosphatase SHP1 as a key ...
Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells [0.03%]
Evi1通过调控Kdm6b介导的组蛋白去甲基化作用来调节造血祖细胞中Laptm4b驱动的mTOR途径
Qiong Wu,Chunjie Yu,Fang Yu et al.
Qiong Wu et al.
Ecotropic viral integration site 1 (EVI1/MECOM) is frequently upregulated in myeloid malignancies. Here, we present an Evi1-transgenic mouse model with inducible expression in hematopoietic stem/progenitor cells (HSPCs). Upon induction of E...
Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1 [0.03%]
内皮BMAL1在衰老过程中通过破坏细胞外微纤维蛋白-1而导致骨质流失
Ying Yin,Qingming Tang,Jingxi Yang et al.
Ying Yin et al.
The occurrence of aging is intricately associated with alterations in circadian rhythms that coincide with stem cell exhaustion. Nonetheless, the extent to which the circadian system governs skeletal aging remains inadequately understood. H...
The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals [0.03%]
本杰明·巴顿的肌干细胞故事：通过保健品恢复肌肉再生能力
Taylor Peach,Mattia Quattrocelli
Taylor Peach
Aging negatively affects the capacity of muscle stem cells (MuSCs) to regenerate muscle. In this issue of the JCI, Ancel, Michaud, and colleagues used a high-content imaging screen to identify nicotinamide and pyridoxine as promoters of MuS...
Beyond ketosis: the search for the mechanism underlying SGLT2-inhibitor benefit continues [0.03%]
超越酮症：SGLT2抑制剂益处作用机制的探索仍在继续
Justin H Berger,Brian N Finck
Justin H Berger
Despite the impressive clinical benefits and widespread adoption of sodium glucose cotransporter 2 inhibitors (SGLT2i) to treat all classes of heart failure, their cardiovascular mechanisms of action are poorly understood. Proposed mechanis...
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts [0.03%]
健康和衰竭的 rat 心脏中 SGLT2 抑制改变底物利用和线粒体还原态
Leigh Goedeke,Yina Ma,Rafael C Gaspar et al.
Leigh Goedeke et al.
Previous studies highlight the potential for sodium-glucose cotransporter type 2 (SGLT2) inhibitors (SGLT2i) to exert cardioprotective effects in heart failure by increasing plasma ketones and shifting myocardial fuel utilization toward ket...
Estimation of prevalence of autoimmune diseases in the United States using electronic health record data [0.03%]
基于电子健康记录数据估算美国自身免疫性疾病患病率
Aaron H Abend,Ingrid He,Neil Bahroos et al.
Aaron H Abend et al.
Background: Previous epidemiologic studies of autoimmune diseases in the United States (US) have included a limited number of diseases or used meta-analyses that rely on different data collection methods and analyses for ...
Clinical tolerance but no protective efficacy in a placebo-controlled trial of repeated controlled schistosome infection [0.03%]
临床耐受性但缺乏保护效果：重复可控血吸虫感染的安慰剂对照试验结果
Jan Pieter R Koopman,Emma L Houlder,Jacqueline J Janse et al.
Jan Pieter R Koopman et al.
Background: Partial protective immunity to schistosomiasis develops over time, following repeated praziquantel treatment. Moreover, animals develop protective immunity after repeated immunisation with irradiated cercariae...
Senescence of endothelial cells increases susceptibility to Kaposi's sarcoma-associated herpesvirus infection via CD109-mediated viral entry [0.03%]
内皮细胞衰老通过CD109介导的病毒进入而增加卡波西肉瘤相关疱疹病毒感染的易感性
Myung-Ju Lee,Jun-Hee Yeon,Jisu Lee et al.
Myung-Ju Lee et al.
The aging process is characterized by cellular functional decline and increased susceptibility to infections. Understanding the association between virus infection and aging is crucial for developing effective strategies against viral infec...