Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer [0.03%]
题为“一个完整的闰盘复合体在心脏发育和功能中具有机械整合作用”的文章报告了以下内容。
Yuri Kim,Seong Won Kim,David Saul et al.
Yuri Kim et al.
Heterozygous truncating variants in the sarcomere protein titin (TTN) are the most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte TTN expression we characterized highly conserved intron ...
NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis [0.03%]
NEDD4L介导肠上皮细胞铁死亡以限制炎症性肠病和结直肠肿瘤发生
Jingjing Liang,Ning Wang,Yihan Yao et al.
Jingjing Liang et al.
Various factors play key roles in maintaining intestine homeostasis. Disruption of the balance may lead to intestinal inflammatory diseases (IBDs) and even colorectal cancer (CRC). Loss or gain of function of many key proteins can result in...
Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice [0.03%]
小鼠肠道Cyp24a1可独立于肾脏Cyp24a1的系统调节局部调节维生素D
Michaela Aa Fuchs,Alexander Grabner,Melody Shi et al.
Michaela Aa Fuchs et al.
Vitamin D regulates mineral homeostasis. The most biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), is synthesized by CYP27B1 from 25-dihydroxyvitamin D (25D) and inactivated by CYP24A1. Human monogenic diseases and ge...
Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study [0.03%]
克里扎努单抗治疗视网膜血管病伴脑白质病的Ⅱ期临床研究
Wilson X Wang,Dan Spiegelman,P Kumar Rao et al.
Wilson X Wang et al.
CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA [0.03%]
CRISPR/Cas13d通过抑制C9orf72六核苷酸重复序列RNA的非AUG起始翻译来降低其表达水平
Honghe Liu,Xiao-Feng Zhao,Yu-Ning Lu et al.
Honghe Liu et al.
The paradox of eGFR trends and kidney failure incidence in patients without monogenic kidney disorders. Reply [0.03%]
eGFR变化趋势与非单基因肾脏疾病患者肾衰竭发病率的悖论答复
Mark Elliott,Krzysztof Kiryluk,Ali Gharavi
Mark Elliott
Interleukin 10 drives Staphylococcus aureus imprinting and vaccine failure in murine models via antibody glycosylation [0.03%]
白细胞介素10通过抗体糖基化驱动金黄色葡萄球菌印记并导致小鼠模型疫苗失效
Victor J Torres
Victor J Torres
Despite many attempts, there is currently no approved vaccine to prevent Staphylococcus aureus infections. Preclinical vaccination models have failed to predict vaccine efficacy in humans as S. aureus exposure in humans imprints an immune r...
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination [0.03%]
病原体驱动的IL-10抗体岩藻糖基化损害疫苗效力
Chih-Ming Tsai,Irshad A Hajam,J R Caldera et al.
Chih-Ming Tsai et al.
The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that ...
Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors [0.03%]
针对TMED货物受体靶向治疗可逆转尿黏蛋白转运障碍
Silvana Bazua-Valenti,Matthew R Brown,Jason Zavras et al.
Silvana Bazua-Valenti et al.
The trafficking dynamics of uromodulin (UMOD), the most abundant protein in human urine, play a critical role in the pathogenesis of kidney disease. Monoallelic mutations in the UMOD gene cause autosomal dominant tubulointerstitial kidney d...