Neutrophil-microglia interaction drives motor dysfunction in neuromyelitis optica model induced by subarachnoid AQP4-IgG [0.03%]
蛛网膜注射AQP4-IgG的视神经脊髓炎模型中中性粒细胞-小胶质细胞相互作用导致运动障碍
Fangfang Qi,Vanda A Lennon,Shunyi Zhao et al.
Fangfang Qi et al.
Neutrophils and neutrophil extracellular traps (NETs) contribute to early neuromyelitis optica (NMO) histopathology initiated by IgG targeting astrocytic aquaporin-4 water (AQP4) channels. Yet, the mechanisms underlying neutrophil recruitme...
Sinus mast cell accumulation and persistence suggest a unique endotype in toxin exposure-associated chronic rhinosinusitis [0.03%]
毒物暴露相关的慢性鼻窦炎中积聚和持续存在的鼻窦肥大细胞表明存在一种独特的疾病亚型
Xinyu Wang,Yung-An Huang,Anshika Sethi et al.
Xinyu Wang et al.
Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma [0.03%]
APOB稀有变异体的携带预示严重脂肪性肝病和肝细胞癌风险增加
Matteo Mureddu,Serena Pelusi,Oveis Jamialahmadi et al.
Matteo Mureddu et al.
Background: MASLD has a substantial inherited component. Rare variants in Apolipoprotein B gene (APOB) have been implicated in susceptibility to liver steatosis, but their role in disease progression and outcomes is uncle...
Proteogenomic characterization of cervical cancer identifies molecular subtypes predictive of clinical outcomes and subtype-specific targets [0.03%]
宫颈癌的蛋白质基因组特征鉴定出预测临床结果的分子亚型和特定亚型靶点
Xun Tian,Mansheng Li,Zhi Wang et al.
Xun Tian et al.
Cervical cancer (CC) remains the fourth leading cause of cancer-related deaths in women globally, with poor prognosis for metastatic and recurrent cases. Although genomic alterations have been extensively characterized, global proteogenomic...
Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases [0.03%]
自身抗体热点揭示了免疫原性XIST核糖核蛋白复合物在自身免疫疾病中的起源和影响
Bingyu Yan,Jinwoo Lee,Suhas Srinivasan et al.
Bingyu Yan et al.
A Trypanosoma cruzi trans-sialidase peptide demonstrates high serological prevalence among infected populations across endemic regions [0.03%]
一种克氏锥虫转化唾液酸酶肽在感染人群中的血清阳性率较高
Hannah M Kortbawi,Ryan J Marczak,Jayant V Rajan et al.
Hannah M Kortbawi et al.
Background: Infection by Trypanosoma cruzi, the agent of Chagas disease, is endemic to the Americas and can irreparably damage the cardiac and gastrointestinal systems during decades of parasite persistence. Diagnosis of ...
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell mediated regeneration [0.03%]
TP53/TAU轴调节微管聚集以控制肺泡干细胞介导的再生
Satoshi Konishi,Khaliun Enkhbayar,Shuyu Liu et al.
Satoshi Konishi et al.
Cells exhibit diverse sizes and shapes, tailored for functional needs of tissues. Lung alveoli are lined by large, extremely thin epithelial alveolar type-1 cells (AT1s). Their characteristic morphology is essential for lung function and mu...
Biallelic GLTP mutations cause nonsyndromic epidermal differentiation disorder via disrupted epidermal glucosylceramide transport [0.03%]
GLTP双等位基因突变通过扰乱皮肤类糖脂转运引起非综合征性皮肤病変
Zeqiao Zhang,Shimiao Huang,Adam Jackson et al.
Zeqiao Zhang et al.
Ceramides are essential skin lipids for maintaining the mammalian skin permeability barrier, which protects against external stimuli. The precursor of epidermal ceramides, glucosylceramides (GlcCer), is synthesized within granular keratinoc...
Adam9-deficient retinal pigment epithelium pseudopods maintain photoreceptor outer segment renewal despite subretinal space expansion [0.03%]
无腺苷酸脱氨酶9的视网膜色素上皮伪足在脉络膜上腔扩大时维持光感受器外节更新
Tylor R Lewis,Carson M Castillo,Sebastien Phan et al.
Tylor R Lewis et al.
Vision begins in the outer segment compartment of photoreceptor cells, which is constantly renewed through the addition of membrane material at its base and ingestion of mature membranes at its tip by the retinal pigment epithelium (RPE). T...
Overexpression of the ERG oncogene in prostate cancer identifies candidates for PARP inhibitor-based radiosensitization [0.03%]
ERG癌基因在前列腺癌中的过表达确定了基于PARP抑制剂的放疗增敏候选对象
Sabrina Köcher,Mohamed E Elsesy,Ayham Moustafa et al.
Sabrina Köcher et al.
Radiotherapy (RT) is a central treatment for prostate cancer (PCa), acting by inducing DNA double-strand breaks (DSBs). Tumor ability to repair these breaks limits RT efficacy, making DSB repair inhibitors potential radiosensitizers. Theref...