Characterization of elite controllers with undetectable intact HIV DNA reservoir [0.03%]
完整HIV-DNA贮存库检测不到的精英控制者特征分析
Jana Blazkova,Brooke D Kennedy,Jesse S Justement et al.
Jana Blazkova et al.
Cardiac radiotherapy-induced epigenetic memory underlies electrophysiologic and metabolic reprogramming [0.03%]
心脏放射治疗诱导的表观遗传记忆决定了心电生理和代谢重编程
Samuel D Jordan,Shuhua Fu,Abigail Fulkerson et al.
Samuel D Jordan et al.
Stereotactic arrhythmia radiotherapy (STAR) is emerging as a highly effective treatment for ventricular tachycardia (VT). Growing evidence indicates that STAR favorably reprograms the electrical substrate by speeding conduction and/or prolo...
Pathobiont-triggered induction of goblet cell response drives regional susceptibility to Inflammatory Bowel Disease [0.03%]
病原生物触发杯状细胞反应驱动炎症性肠病区域易感性
Paige N Spencer,Monica E Brown,Erin P Smith et al.
Paige N Spencer et al.
The gastrointestinal tract varies in structure and function by region, yet the drivers of region-specific inflammatory disease remain elusive. Here, a TNF-overexpressing murine model (TnfΔARE/+) of Crohn's disease (CD) was used to investig...
Inflammation- and resolution-programmed myeloid circuits govern therapeutic resistance in epithelial and mesenchymal triple-negative breast cancer [0.03%]
炎症和解决计划的髓样电路治理上皮和间质型三阴性乳腺癌的治疗抵抗性
Liqun Yu,Charlotte Rivas,Fengshuo Liu et al.
Liqun Yu et al.
Single-cell analysis of human triple-negative breast cancer revealed heterogeneous macrophage populations with opposing phenotypes-pro-inflammatory and pro-resolution of inflammation. Paradoxically, both subsets accumulated in therapy-refra...
Dilan Athauda,Nigel H Greig,Wassilios G Meissner et al.
Dilan Athauda et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), established therapies for type 2 diabetes and obesity, are increasingly recognized for their potential in neurodegenerative diseases. Preclinical studies across diverse neurodegenerative...
Predicting checkpoint inhibitor-associated autoimmune diabetes: prospects and limitations [0.03%]
预测检查点抑制剂相关自身免疫糖尿病的发生：前景与局限性
Kevan C Herold,Ana Luisa Perdigoto
Kevan C Herold
Checkpoint inhibitor-associated autoimmune diabetes (CIADM) is a life-altering and potentially life-threatening complication of immune checkpoint inhibitor (ICI) treatment in patients with cancer. Risk factors and predictors of this complic...
The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers [0.03%]
一种机器学习算法能够利用移植后的生物标志物预测慢性移植物抗宿主病和死亡风险
Michael J Martens,Debjani Dutta,Yongzi Yu et al.
Michael J Martens et al.
BACKGROUNDChronic graft-versus-host disease (cGVHD) is a major contributor to nonrelapse mortality (NRM) following hematopoietic cell transplantation (HCT). Whether machine-learning (ML) models with biomarkers improve the accuracy for predi...
Immune correlates of HIV-1 rebound during broadly neutralizing antibody treatment in young children [0.03%]
广谱中和抗体治疗期间人类免疫缺陷病毒-1反弹与免疫力的相关性——一项针对儿童患者的研究
Aischa Niesar,Melanie Lancien,Seohyun Hong et al.
Aischa Niesar et al.
Broadly neutralizing antibodies (bnAbs) are evaluated as possible alternatives to standard antiretroviral treatment (ART) for maintaining control of HIV-1 replication and may enhance immune responses to reduce or control the viral reservoir...
Cotargeting DNA topoisomerase II enhances efficacy of RAS-targeted therapy in KRAS-mutant cancer models [0.03%]
DNA拓扑异构酶II联合靶向治疗增强RAS靶向疗法在KRAS突变癌症模型中的疗效
Rongzhong Xu,Dongsheng Wang,Guangzhi Ma et al.
Rongzhong Xu et al.
The approval of sotorasib and adagrasib as the first KRAS G12C inhibitors has made the RAS oncogene a druggable target. However, they have modest objective response rates and short response durations. Therefore, strategies for improving RAS...
Jason A Somarelli,Jason W Arnold,Andrew B West
Jason A Somarelli