α4 integrin blockade impairs CD8 T cell neuroimmune surveillance following SIV infection [0.03%]
阻断α4整合素会损害SIV感染后的CD8T细胞神经免疫监视功能
Pabitra B Pal,Sonny R Elizaldi,Giovanne B Diniz et al.
Pabitra B Pal et al.
Integrin-targeted therapies are under investigation for HIV associated neuroinflammation, yet their impact on CNS anti-viral immunity remains undefined. We examined the role of α4 integrin in T cell mediated neuroimmune surveillance using ...
Long-acting parathyroid hormone receptor agonist rectifies hypocalcemia in autosomal dominant hypocalcemia type 1 mice [0.03%]
长效甲状旁腺激素受体激动剂可纠正自身显性低钙血症1型小鼠的低钙血症
Fadil M Hannan,Mark Stevenson,Taha Elajnaf et al.
Fadil M Hannan et al.
Disrupted Neurovascular-Endocrine Coupling in Type 1 Diabetes with impaired awareness of hypoglycaemia [0.03%]
1型糖尿病伴低血糖未察觉症患者的神经血管-内分泌耦联障碍
Pavel Filip,Antonietta Canna,Heidi Grohn et al.
Pavel Filip et al.
Recurrent hypoglycaemia in type 1 diabetes (T1D) may culminate in impaired awareness of hypoglycaemia (IAH). While neuroimaging studies identified affected brain regions, more complex perspectives integrating vascular dynamics with endocrin...
Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice [0.03%]
神经SEL1L-HRD1内质网相关降解对小鼠运动功能和存活必不可少
Mauricio Torres,You Lu,Brent Pederson et al.
Mauricio Torres et al.
Hypomorphic variants in the SEL1L-HRD1 ER-associated degradation (ERAD) complex have been linked to severe neurological syndromes in children, including neurodevelopmental delay, intellectual disability, motor dysfunction, and early death. ...
AAV-mediated gene therapy in a SLC13A5 citrate transporter disorder model rescues epileptic and metabolic phenotypes [0.03%]
利用AAV介导的基因治疗逆转SLC13A5柠檬酸转运蛋白障碍模型中的癫痫和代谢表型
Lauren E Bailey,Raegan M Adams,Morgan K Schackmuth et al.
Lauren E Bailey et al.
SLC13A5 citrate transporter disorder is a rare epileptic encephalopathy caused by loss of function pathogenic variants in the SLC13A5 gene. Loss of sodium/citrate cotransporter (NaCT) function causes a severe early life epilepsy resulting i...
Distinct HIF1α and HIF2α functions control skeletal muscle metabolism and erythropoiesis [0.03%]
不同的HIF1α和HIF2α功能控制骨骼肌代谢和红细胞生成
Junhyeong Lee,Merc Emil Matienzo,Sangyi Lim et al.
Junhyeong Lee et al.
Skeletal muscle frequently experiences oxygen depletion, especially during exercise, and the alpha subunit of the hypoxia-inducible factors (HIF1α and HIF2α) plays a crucial role in mediating cellular adaptation to low oxygen levels. Howe...
GSDME/IL-18 pyroptotic axis prevents myosteatosis by expanding tissue-resident macrophages to promote muscle regeneration [0.03%]
GSDME/IL-18焦亡轴通过扩增组织驻留巨噬细胞促进肌肉再生从而预防肌脂变性
Qi Cao,Jian Liu,Gang Huang et al.
Qi Cao et al.
Metabolic-inflammatory crosstalk orchestrates muscle repair. Although pyroptosis typically aggravates sterile injury, we demonstrated that GSDME-dependent pyroptotic signaling associated with recruited myeloid cells paradoxically supported ...
A CD57+ CD8 T cell subset links cytotoxic T cell cytotoxicity to fibrotic lung disease in systemic sclerosis [0.03%]
系统性硬化病中CD57+CD8T细胞亚群将CTL毒性与肺纤维化相联系
Takanori Sasaki,Ye Cao,John M Sowerby et al.
Takanori Sasaki et al.
Interstitial lung disease (ILD) is a major cause of morbidity and mortality in systemic sclerosis (SSc); however, the immunopathologic mechanisms driving lung disease in SSc are unclear. T cells have been implicated as a likely driver of lu...
Galectin-3 mediates lysosome-related inflammation within monocyte-derived macrophages in a mouse model of ischemic brain injury [0.03%]
半乳糖凝集素3介导小鼠缺血性脑损伤单核细胞衍生巨噬细胞中与溶酶体相关的炎症反应
Miao Wang,Zhentai Huang,Zhihong Du et al.
Miao Wang et al.
Circulating monocyte-derived macrophages (MDMø) rapidly invade the brain after stroke, exerting both detrimental and beneficial effects. Elucidating mechanisms that mediate detrimental properties of MDMø may identify therapeutic strategie...
Postnatal Slc26a4 gene therapy improves hearing and structural integrity in a hereditary hearing loss model [0.03%]
产后Slc26a4基因治疗可改善遗传性听力损失模型的小鼠的听力和结构完整性
Yi-Hsiu Tsai,Peng-Yu Wu,Yu-Chi Chuang et al.
Yi-Hsiu Tsai et al.
Mutations in SLC26A4 are the second most common cause of hereditary hearing loss in many Asian countries, leading to DFNB4, a condition characterized by progressive hearing loss and inner ear malformations. While gene therapy holds great po...