Macrophage-rich niches regulate T cell dynamics at the liver invasive margin during gallbladder cancer progression [0.03%]
巨噬细胞丰富的微环境调节胆囊癌进展过程中肝脏浸润边缘的T细胞动态变化
Maolan Li,Zhaonan Liu,Shenbing Shan et al.
Maolan Li et al.
Liver invasion is one of the most frequent events in the progression of gallbladder cancer (GBC). However, the cellular and pathological role of the tumor-liver-interface microenvironment in liver invasion is still enigmatic. Here, we appli...
IFN signaling at the nexus of the radiotherapy response in malignant peripheral nerve sheath tumors [0.03%]
干扰素信号在恶性外周神经鞘肿瘤放疗反应中的作用节点研究
Sean P Pitroda,Ralph R Weichselbaum
Sean P Pitroda
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that constitute a major cause of mortality in individuals with neurofibromatosis type 1 (NF-1) and exhibit highly variable responses to radiotherapy. In this issue of...
IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors [0.03%]
干扰素信号与恶性外周神经鞘瘤放疗反应相关性研究
Iowis Zhu,Julian Chien,Gabriel E Rech et al.
Iowis Zhu et al.
Patients with malignant peripheral nerve sheath tumors (MPNSTs) have poor outcomes despite multimodal treatment with surgery, radiation, and systemic therapy. The responses to radiotherapy (RT) are mixed, and the biologic mechanisms underly...
Disruption of CSF-1 receptor-mediated metal ion homeostasis in the murine brain promotes neurodegenerative disease [0.03%]
小鼠脑中的CSF-1受体介导的金属离子稳态紊乱促进神经退行性疾病发生发展
Violeta Chitu,Julia Alvarenga,Wenna Chen et al.
Violeta Chitu et al.
Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/- mouse. CRL is caused by microglial ...
CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic and tolerogenic properties [0.03%]
新生儿人naïve CD4+ T细胞中CD38的表达决定了其独特的代谢和耐受特性
Laura R Dwyer,Andrea M DeRogatis,Sean Clancy et al.
Laura R Dwyer et al.
Neonatal life is marked by rapid antigen exposure, necessitating establishment of peripheral immune tolerance via conversion of naïve CD4+ T cells into regulatory T cells (Tregs). Here, we demonstrated heightened capacity for FOXP3 express...
MEK inhibitor Mirdametinib promotes fracture healing in osteofibrous dysplasia RASopathy [0.03%]
MEK抑制剂Mirdametinib可促进骨纤维发育不良RAS障碍的骨折愈合
Aysha Khalid,Kristin Denton,Nandina Paria et al.
Aysha Khalid et al.
Osteofibrous dysplasia (OFD) is a skeletal RASopathy presenting with periosteal bone lesions that may progress to fracture and delayed healing (pseudarthrosis). MET gene mutations reducing ubiquitin-mediated protein degradation via loss of ...
RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis [0.03%]
RNA结合蛋白LARP6调控肝星状细胞活化及肝纤维化
Hyun Young Kim,Orel Mizrahi,Wonseok Lee et al.
Hyun Young Kim et al.
Metabolic syndrome and excessive alcohol consumption (MetALD) result in liver injury and fibrosis, which is driven by increased collagen production by activated hepatic stellate cells (HSCs). Our previous studies demonstrated that LARP6, an...
Tet2-driven clonal hematopoiesis drives aortic aneurysm via macrophage-to-osteoclast-like differentiation [0.03%]
Tet2诱导的克隆性血液病通过巨噬细胞向破骨细胞样分化驱动主动脉瘤形成
Jun Yonekawa,Yoshimitsu Yura,Junmiao Luo et al.
Jun Yonekawa et al.
Aortic aneurysms are age-linked aortic dilations that progress silently and carry high rupture mortality. Immune cells are recognized drivers of aneurysm pathogenesis. Clonal hematopoiesis is an age-related expansion of somatically mutated ...
Tumor cell-derived IFN spatially reprograms osteopontin-enriched macrophage niches to promote PARP inhibitor resistance [0.03%]
肿瘤细胞来源的干扰素通过空间重塑富含骨桥蛋白的巨噬细胞生态位来促进PARP抑制剂耐药性
Dan Liu,Kangjia Tao,Cheng Xu et al.
Dan Liu et al.
Poly (ADP-ribose) polymerase inhibitors (PARPi) benefit homologous recombination-deficient (HRD) malignancies, yet resistance remains a major challenge. Leveraging specimens from a prospective neoadjuvant niraparib monotherapy trial in trea...
Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model [0.03%]
凋亡相关斑点样蛋白促进闭合性颅脑损伤小鼠模型中的持续性神经炎症和轻度认知障碍
Tao Li,Sergio Castro-Gomez,Pablo Botella Lucena et al.
Tao Li et al.
Mild traumatic brain injury (mTBI) from closed-head injuries (CHI) can lead to prevalent neuropsychiatric disorders, including mood disorders and an increased risk for neurodegenerative diseases and dementia. Inflammasomes are molecular com...