The Parkinson's pandemic: prioritizing environmental policy and biological resilience via the gut [0.03%]
帕金森病的流行：通过肠道优先考虑环境政策和生物韧性
Bianca Palushaj,Robin M Voigt
Bianca Palushaj
Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance [0.03%]
三阴性乳腺癌转移灶的全面基因组分析确定PKD1在免疫治疗抵抗中的作用
Xiu-Zhi Zhu,Yi-Fan Zhou,Xiao-Han Ying et al.
Xiu-Zhi Zhu et al.
The multi-omics data represented by genomic data from patients with metastatic triple-negative breast cancer (TNBC) is crucial for precision treatment, yet data on genomic alterations in metastatic cohorts and Chinese populations remains li...
TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress [0.03%]
TLR4维持肝外科应激模型中Treg介导的保护作用
Hongji Zhang,Yunwei Zhang,Tianxing Ren et al.
Hongji Zhang et al.
Surgical stress, such as hepatic ischemia-reperfusion (I/R) injury, induces excessive inflammation and adversely affects liver surgery outcomes. Regulatory T cells (Tregs) are crucial for immune homeostasis, yet their protective mechanisms ...
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson's disease models [0.03%]
N-乙酰-L-亮氨酸可降低帕金森病模型中的α-突触核蛋白水平并改善突触功能
Pingping Song,Chuyu Chen,Rossella Franchini et al.
Pingping Song et al.
N-acetyl-l-leucine (NALL), a derivative of the branched-chain amino acid leucine, has shown therapeutic potential for neurodegenerative diseases, including in prodromal stages of Parkinson's disease (PD). However, the mechanism of its prote...
The changing landscape of urothelial carcinoma: on the edge of a paradigm shift [0.03%]
尿路上皮癌的治疗格局改变：范式转换正在进行中
Joshua J Meeks
Joshua J Meeks
Urothelial cancers of the urinary tract are the fourth most common malignancy in men, with a shifting demographic affecting younger patients and an increasing incidence in females. In this Review, we discuss recent discoveries and paradigm-...
Tumor-intrinsic chromatin programs enforce immune evasion in glioblastoma [0.03%]
胶质母细胞瘤中肿瘤内在的染色质程序导致免疫逃逸
Raymond Sun,Chao Gao,Rongze Olivia Lu
Raymond Sun
Immunotherapy has shown limited efficacy in glioblastoma (GBM), reflecting profound immune evasion and an immunosuppressive microenvironment. In this Commentary, we highlight recent work by Zhang and colleagues identifying the transcription...
Safeguarding lymphatic identity: cooperative Erg and Fli1 activity in lymphatic vascular homeostasis [0.03%]
淋巴身份的维持：Erg和Fli1在淋巴管血管稳态中的协同活性
Kelly de Korodi,Tatiana V Petrova
Kelly de Korodi
Although transcriptional programs driving lymphatic endothelial cell (LEC) specification are being increasingly characterized, far less is known about the postnatal mechanisms that preserve lymphatic vessel identity and function. In this is...
Deep biochemical phenotyping reveals prognostic value of rare genetic variants in adult kidney stone disease [0.03%]
深度生化表型分析揭示成人肾结石疾病中罕见基因变异的预后价值
Johannes Münch,Jana Petrovska,Joana Figueiro-Silva et al.
Johannes Münch et al.
BACKGROUNDKidney stone disease (KSD) affects approximately 10% of the population. While genetic factors are known to play a role in KSD, determining the clinical relevance of rare variants in KSD genes identified in adults remains challengi...
Observational Study
The Journal of clinical investigation. 2026 Mar 2;136(5):e196277. DOI:10.1172/JCI196277 2026
Organized immunity in the CNS: what stroke reveals about neuroinflammation and lymphoid niches [0.03%]
中枢神经系统的组织免疫：卒中揭示的神经炎症和淋巴细胞生态位的现象
Catalina Lee-Chang
Catalina Lee-Chang
Organized adaptive immunity can emerge in the CNS under specific inflammatory and stromal conditions. The study by Yang et al. in this issue of the JCI reports that experimental ischemic stroke induced germinal center-like B cell follicles ...
α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models [0.03%]
富马酸二氢钠通过表观遗传调控代谢重编程在骨关节炎模型中保护软骨损伤
Shuaijun Li,Jiefeng Huang,Ting Shang et al.
Shuaijun Li et al.
The link between glutaminolysis and osteoarthritis (OA) has only recently begun to be elucidated. Here, we report the association of obesity- and injury-induced cartilage damage with impaired glutaminolysis in chondrocytes. Defective glutam...