Helping alveolar macrophages live to fight another day during viral pneumonia [0.03%]
助力肺泡巨噬细胞在病毒性肺炎中持续作战
Elise Mr Armstrong,Joseph P Mizgerd
Elise Mr Armstrong
Alveolar macrophages (AMs) help defend the lungs against infection, but during pneumonia many alveolar macrophages die. In this issue of the JCI, Malainou et al. explored the mechanism underpinning AM death during viral pneumonia and its ef...
Bispecific antibodies and CAR T cells targeting a TP53 mutation-associated neoantigen show discordant affinity requirements [0.03%]
双特异抗体和靶向TP53突变相关新抗原的CAR-T细胞显示出不同的亲和力要求
Sarah R DiNapoli,Katharine M Wright,Brian J Mog et al.
Sarah R DiNapoli et al.
Mutation-associated neoantigens (MANAs) are highly cancer-specific targets for immunotherapy where peptides derived from intracellular mutant proteins are presented on the cell surface via HLA molecules. T cell-engaging bispecific antibodie...
Gregory Austin,Alejandra Tomas
Gregory Austin
The glucagon-like peptide-1 receptor (GLP-1R) is a class B1 G protein-coupled receptor and major therapeutic target in type 2 diabetes and obesity. Beyond its canonical role in Gαs/cAMP signaling, GLP-1R is increasingly recognized as an or...
Lisa R Beutler
Lisa R Beutler
Historically, antiobesity medications have been modestly effective at best, with side-effect profiles that limit compliance and often preclude the long-term therapy required to maintain weight loss. Recently developed therapies based on ana...
Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis [0.03%]
神经信号和GPR37激活的巨噬细胞efferocytosis介导的保护素DX缓解小鼠骨折术后疼痛
Yize Li,Sangsu Bang,Jasmine Ji et al.
Yize Li et al.
Protectin DX (PDX) is a member of the superfamily of specialized proresolving mediators and exerts anti-inflammatory actions in animal models; however, its signaling mechanism remains unclear. Here, we demonstrate the analgesic actions of P...
Elevated tRNA halves in olfactory epithelial cells of patients with schizophrenia [0.03%]
精神分裂症患者嗅上皮细胞中tRNA halves水平升高
Justin T Gumas,Megumi Shigematsu,Karin E Borgmann-Winter et al.
Justin T Gumas et al.
Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics. ...
Targeting the N-acetyltransferase 10/DKK2 axis enhances CD8+ T cell antitumor activity in colorectal cancer models [0.03%]
靶向N-乙酰转移酶10/DKK2轴可增强CD8+T细胞在结直肠癌模型中的抗肿瘤活性
Mengmeng Li,Xiaoya Zhao,Jun Wu et al.
Mengmeng Li et al.
Despite overexpression of N-acetyltransferase 10 (NAT10) in colorectal cancer (CRC), its immunomodulatory role in the tumor microenvironment remains elusive. Here, we reveal that NAT10 promotes immune evasion through N4-acetylcytosine-depen...
Retraction for Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation [0.03%]
苍术素I通过激活肿瘤抗原呈递增强免疫检查点阻断疗法的响应研究撤稿通知书
Hanchen Xu,Kevin Van der Jeught,Zhuolong Zhou et al.
Hanchen Xu et al.
Retraction for Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer [0.03%]
染色单体黏连复合物成员单位突变赋予癌症治疗弱点的文章的撤稿启事
Yunhua Liu,Hanchen Xu,Kevin Van der Jeught et al.
Yunhua Liu et al.
Giulia Guerra,Marco Mergiotti,Hossein Ardehali et al.
Giulia Guerra et al.
Advances in cancer therapy have greatly extended patient survival but have also introduced a growing burden of cardiovascular toxicity that threatens long-term outcomes. These toxicities encompass a broad and often unpredictable range of cl...