Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use [0.03%]
同时抑制COX-1和COX-2不足以引起慢性使用NSAIDs相关的肠病
Kayla Barekat,Soumita Ghosh,Christin Herrmann et al.
Kayla Barekat et al.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medications for the management of chronic pain; however, they are associated with numerous gastrointestinal (GI) adverse events. Although many mechanisms have been sugge...
PARP inhibitors restore NK cell function via secretory crosstalk with tumor cells in prostate cancer [0.03%]
PARP抑制剂通过与肿瘤细胞的分泌交叉对话恢复NK细胞功能前列腺癌中的作用机制研究
Zheng Chao,Le Li,Xiaodong Hao et al.
Zheng Chao et al.
Prostate cancer (PCa) is one of the most frequently diagnosed malignancies and the main cause of cancer-related death in men worldwide. Poly (ADP-ribose) polymerase (PARP) inhibitors have been approved for the treatment of PCa harboring BRC...
Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism [0.03%]
术中动脉和静脉采样评估非小细胞肺癌的体内代谢特征
Johnathan R Kent,Keene L Abbott,Rachel Nordgren et al.
Johnathan R Kent et al.
Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and ADHD [0.03%]
非典型性多巴胺转运蛋白缺乏综合征小鼠模型揭示与帕金森氏症和注意力缺陷多动障碍相关的多巴胺功能异常
Freja Herborg,Lisa K Konrad,Søren H Jørgensen et al.
Freja Herborg et al.
Atypical dopamine transporter (DAT) deficiency syndrome (DTDS) arises from genetic disruption of DAT function and is characterized by early-onset parkinsonism alongside comorbid psychiatric symptoms. However, the underlying pathobiological ...
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion by suppressing CXCL10 and CD8+ T cell activation [0.03%]
少突胶质细胞转录因子2通过抑制CXCL10和活化CD8+t细胞来促进胶质母细胞瘤免疫逃逸
Xinchun Zhang,Jinjiang Xue,Cunyan Zhao et al.
Xinchun Zhang et al.
Glioblastoma (GBM) is a highly lethal brain tumor with limited treatment options and resistance to immune checkpoint inhibitors due to its immunosuppressive tumor microenvironment (TME). Here, we identify OLIG2 as a key regulator of immune ...
Rho/ROCK signaling and α-Catenin mediate β-Catenin-driven hyperplasia in the adrenal cortex via adherens junctions [0.03%]
Rho/ROCK信号和α-E-钙黏蛋白通过黏着斑介导β-E-钙黏蛋白引起的肾上腺皮质增生
Mesut Berber,Betul Haykir,Nick A Guagliardo et al.
Mesut Berber et al.
How β-Catenin (βCat) mediates tissue hyperplasia is poorly understood. To explore this, we employed the adrenal cortex as a model system given its stereotypical spatial organization and the important role βCat plays in homeostasis and di...
Dermal fibroblasts respond to interleukin-4 and 13 and promote T-cell recruitment in atopic dermatitis [0.03%]
特应性皮炎中真皮成纤维细胞对白细胞介素4和13的反应以及促进T细胞募集的作用
Tomofumi Numata,Michael Shia,Yoshiyuki Nakamura et al.
Tomofumi Numata et al.
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a type 2 immune response that is not fully understood. Single-cell RNA sequencing (scRNA-seq) of human AD skin and murine models of type 2 inflammation identif...
ATR Safeguards Epithelial-to-Mesenchymal Transition by Countering R-loops and Enabling Transcription Reprogramming [0.03%]
ATR通过对抗R环和使转录重新编程来保障上皮间质转化
Parasvi S Patel,Jacob P Matson,Xiaojuan Ran et al.
Parasvi S Patel et al.
Transitions of cancer cells between distinct cell states, which are typically driven by transcription reprogramming, fuel tumor plasticity, metastasis, and therapeutic resistance. Whether the transitions between cell states can be therapeut...
Corrigendum to Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation [0.03%]
轴突引导线索SLIT2通过交感神经支配调节小鼠骨髓基质细胞生态位的修正意见
Zuoxing Wu,Na Li,Zhengqiong Luo et al.
Zuoxing Wu et al.
Published Erratum
The Journal of clinical investigation. 2026 Jan 16;136(2):e203674. DOI:10.1172/JCI203674 2026