A protein-based pneumococcal vaccine elicits broad immunity associated with multifunctional antibody responses in humans [0.03%]
一种基于蛋白质的肺炎球菌疫苗能够诱导与多功能抗体反应相关的广谱免疫反应
Kaiyi Li,Jinglu Yang,Xiaobing Zhai et al.
Kaiyi Li et al.
Traditional polysaccharide vaccines are constrained by streptococcus pneumoniae diversity. We propose a protein-based pneumococcal vaccine (PBPV) - formulated with conserved surface proteins P3296, P5668, PRx1, and pneumolysin (Ply) - that ...
Rhythms of risk: the intersection of clocks, cancer, and chronotherapy [0.03%]
风险的节奏：时钟、癌症与时间治疗学的交汇点
Rebecca M Mello,Selma Masri,Katja A Lamia
Rebecca M Mello
Circadian clocks govern daily rhythms in cellular and physiological processes, including cell cycle, DNA repair, metabolism, and immune function, that influence cancer development and treatment response. Disruption of circadian regulators e...
Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1 [0.03%]
原花青素通过稳定LKB1和SYVN1促进泛素-蛋白酶体降解PD-L1从而增强抗肿瘤免疫反应
Mengting Xu,Xuwen Lin,Hanchi Xu et al.
Mengting Xu et al.
Programmed cell death 1 ligand 1-targeted (PD-L1-targeted) immune checkpoint inhibitors are revolutionizing cancer therapy. However, strategies to induce endogenous PD-L1 degradation represent an emerging therapeutic paradigm. Here, we iden...
MAP4K2 suppresses antitumor immunity in a pancreatic cancer model by promoting Treg differentiation [0.03%]
MAP4K2通过促进Tregs分化在胰腺癌模型中抑制抗肿瘤免疫反应
Huai-Chia Chuang,Chia-Wen Wang,Chia-Hsin Hsueh et al.
Huai-Chia Chuang et al.
MAP kinase kinase kinase kinase (MAP4K) family kinases are key kinases for T-cell-mediated immune responses; however, in vivo roles of MAP4K2 in immune regulation remain unclear. Using T-cell-specific Map4k2 conditional knockout (T-Map4k2 c...
EBF2 variant identified in a patient with atypical partial lipodystrophy causes adipose fibrosis and dysfunction [0.03%]
在不典型部分脂质营养不良患者中鉴别的EBF2变异导致脂肪纤维化和功能障碍
Maria C Foss-Freitas,Donatella Gilio,Lynn Pais et al.
Maria C Foss-Freitas et al.
Lipodystrophy syndromes are marked by loss of adipose tissue (AT), which leads to insulin resistance and metabolic syndrome development. We identified a heterozygous nonsense variant in early B cell factor 2 (EBF2) (Chr8:26033143C>A, NM_022...
Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound [0.03%]
特异性CD8+t细胞反应增强可延长中断抗逆转录病毒治疗后sivmac239的反弹时间
Were R Omange,Benjamin D Varco-Merth,Omo Fadeyi et al.
Were R Omange et al.
HIV/SIV-specific CD8+ T cell responses are typically unable to control viral rebound following antiretroviral therapy (ART) interruption (ATI). To investigate whether enhancing the magnitude and activation of SIV-specific CD8+ T cells at th...
Vascular smooth muscle cell-derived KIF13B protects against atherosclerosis: evidence from humans and mice [0.03%]
血管平滑肌细胞衍生的KIF13B具有抗动脉粥样硬化作用：来自人类和小鼠的证据
Guolin Miao,Yufei Han,Jingxuan Chen et al.
Guolin Miao et al.
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of death worldwide, with plaque instability being a major culprit. Phenotypic switching of vascular smooth muscle cells (VSMCs) is a central event in atherosclerosis, dr...
ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis [0.03%]
ADAMTS7促进动脉粥样硬化平滑肌泡沫细胞的增生
Allen Chung,Lauren E Fries,Hyun-Kyung Chang et al.
Allen Chung et al.
Human genetic studies have repeatedly associated ADAMTS7 with atherosclerotic cardiovascular disease. Subsequent investigations in mice demonstrated that ADAMTS7 is proatherogenic and induced in response to vascular injury. However, the cel...
Targeting Pim2 Improves Antitumor Immunity through Promoting Effector Function and Persistence of CD8 T cells [0.03%]
靶向PIM2通过促进CD8+T细胞的效应功能和持久性来增强抗肿瘤免疫
Yongxia Wu,Linlu Tian,Allison Pugel et al.
Yongxia Wu et al.
The PIM kinase family is critically involved in tumorigenesis, yet its role in primary T cells is understudied. We reported that PIM2, distinct from the other two isoforms, inhibits T-cell responses to alloantigen. Here, we further establis...
Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes [0.03%]
衰老的小鼠骨髓髓系和间质细胞产生独特的衰老表型
Madison L Doolittle,Mitchell N Froemming,Jennifer L Rowsey et al.
Madison L Doolittle et al.
Cellular senescence is a heterogeneous phenotype characterized primarily in mesenchymal cells, but the extent to which immune cells differ in their senescence phenotype, or "senotype", is unclear. Here, we applied single-cell approaches alo...