Unraveling TIME: CD8+ T cell- and CXCL11-driven endocrine resistance in breast cancer [0.03%]
解密TIME：乳腺癌中CD8+T细胞和CXCL11诱导的内分泌耐药性
Tim Kong,Cynthia X Ma
Tim Kong
A major unmet need in estrogen receptor-positive (ER+) breast cancer is understanding the mechanisms that underlie resistance to endocrine therapy. Although accumulating evidence suggests an association between the tumor immune microenviron...
Novel perspectives on extracellular vesicles in autoimmune diseases: immunogenicity, inflammation, and immune surveillance [0.03%]
自身免疫性疾病中外泌体的新视角：免疫原性、炎症和免疫监视
Yin Zhao,Xing Lyu,Xiuhua Wu et al.
Yin Zhao et al.
Cells release extracellular vesicles (EVs) with cargo that originates from distinct subcellular compartments, including the nucleus, cytoplasm, and plasma membrane. Given their diverse cargo, EVs play multiple roles in physiology and pathol...
Next-generation liquid biopsies: detecting circulating epigenetic changes to identify translocation renal cell carcinoma [0.03%]
下一代液体活检：通过检测循环表观遗传变化来识别染色体易位肾细胞癌
Katsuhiro Ito,David A Braun
Katsuhiro Ito
Circulating tumor DNA detection in renal cell carcinoma has long been limited by the disease's low DNA shedding. An aggressive subtype termed translocation renal cell carcinoma (tRCC) is notably more difficult to detect than the common type...
Neurodegeneration biomarkers in Alzheimer's disease: axonal density index expands the "N" in the AT(N) framework [0.03%]
阿尔茨海默病中的神经退行性生物标志物：轴突密度指数在AT(N)框架中扩展了“N”
Ryn Flaherty,Arjun V Masurkar
Ryn Flaherty
Neurodegeneration, along with amyloid and tau, define the AT(N) framework of Alzheimer's disease that has shaped the development of diagnostics and therapeutics. Yet, biomarker development for neurodegeneration has lagged behind that for am...
Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine [0.03%]
探索转移性雄激素敏感前列腺癌的生物学特性：迈向精准医学之路
Alice Bernard-Tessier,Himisha Beltran
Alice Bernard-Tessier
Metastatic hormone-sensitive prostate cancer (mHSPC) is a clinically and molecularly heterogeneous disease. Recent insights into the biology underlying disease presentation, volume of disease, and response to therapies are starting to point...
Fuyi Liao,Andrew E Gelman
Fuyi Liao
Cardiac allograft vasculopathy (CAV) is a fibroproliferative form of transplant rejection with limited treatment options other than retransplantation. In this issue, See and colleagues examined human explanted allografts with CAV. They foun...
Retraction for Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation [0.03%]
Lkb1在骨膜间充质干细胞中的缺失通过激活mTORC1诱导骨生成肿瘤的撤稿通知
Yujiao Han,Heng Feng,Jun Sun et al.
Yujiao Han et al.
Ala Moshiri,Akrit Sodhi
Ala Moshiri
The retinoid chromophore 11-cis-retinal triggers an intracellular cascade known as phototransduction that converts light into electrochemical signals. Enzymatic regeneration of 11-cis-retinal sustains vision, prevents the buildup of toxic b...
Breaking down to rebuild: lymphatic ablation enhances osteoclast-driven regeneration [0.03%]
破而后立：淋巴清除可增强破骨细胞介导的组织再生
Matthijs Luxen,Francesca Lazzeri-Barcelo,Ralf H Adams
Matthijs Luxen
The fingertip is one of the only known complex structures in mammals that can fully regenerate following amputation. This phenomenon can be studied in mice using the amputation of the digit tip, the regenerative success of which has been sh...
Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation [0.03%]
靶向淋巴管通过增加小鼠截肢模型中的破骨细胞活性来增强骨再生
Neda Vishlaghi,Trisha K Ghotra,Monisha Mittal et al.
Neda Vishlaghi et al.
Although mammals generally demonstrate limited regenerative capacity compared with amphibians, the digit tip retains remarkable regenerative potential, providing a useful model to study successful mammalian regeneration. This process involv...