Benjamin Rolles,Ann Mullally
Benjamin Rolles
Purpose of review: Myeloproliferative neoplasms (MPNs) are chronic hematological malignancies characterized by increased proliferation of MPN stem and myeloid progenitor cells with or without bone marrow fibrosis that typ...
Approach Toward Germline Predisposition Syndromes in Patients with Hematologic Malignancies [0.03%]
血液系统恶性肿瘤患者体细胞 predisposition 综合征的诊疗进展
Himachandana Atluri,Yoheved S Gerstein,Courtney D DiNardo
Himachandana Atluri
Purpose of review: Hematologic malignancies were previously thought to be primarily sporadic cancers without germline predispositions. However, over the last two decades, with the widespread use of next generation sequenc...
CML Resistant to 2nd-Generation TKIs: Mechanisms, Next Steps, and New Directions [0.03%]
对二代TKI耐药的CML：机制、下一步及新方向
Emilia Scalzulli,Ida Carmosino,Maria Laura Bisegna et al.
Emilia Scalzulli et al.
Purpose of review: The clinical scenario for chronic myeloid leukemia patients rapidly changed after the introduction of tyrosine kinase inhibitors (TKIs). Second-generation TKIs as frontline treatment increased the rate ...
Therapy Resistance and Disease Progression in CML: Mechanistic Links and Therapeutic Strategies [0.03%]
慢性粒细胞白血病的治疗耐药和疾病进展：机制关联与治疗策略
John Joson Ng,S Tiong Ong
John Joson Ng
Purpose of review: Despite the adoption of tyrosine kinases inhibitors (TKIs) as molecular targeted therapy in chronic myeloid leukemia, some patients do not respond to treatment and even experience disease progression. T...
Swetha Kambhampati,Jasmine Zain
Swetha Kambhampati
Purpose of review: Recent advances have been made in circulating tumor DNA (ctDNA), the method to minimally invasive detect lymphoma sensitively with tumor-derived DNA in the blood of patients with lymphomas. This article...
Prevalence and Determinants of Return to Work as a Patient-Centered Outcome in Survivors of Hematopoietic Cell Transplantation [0.03%]
造血干细胞移植患者的带病就业流行率及其影响因素——一种以患者为中心的结局指标研究
Neel S Bhatt
Neel S Bhatt
Purpose of review: Employment is an important indicator of health and functional recovery for hematopoietic cell transplantation (HCT) survivors and has significant social and economic impacts. Cancer survivors treated wi...
Christineil Thompson,Sydney Ariagno,Mira A Kohorst
Christineil Thompson
Purpose of review: Advances in the understanding of germline predisposition to pediatric cancers, particularly myeloid neoplasms, have increased rapidly over the last 20 years. Here, we highlight the most up-to-date knowl...
Progress and Challenges in Survivorship After Acute Myeloid Leukemia in Adults [0.03%]
成人急性髓系白血病治疗后幸存者的进展与挑战
Ginna Granroth,Nandita Khera,Cecilia Arana Yi
Ginna Granroth
Purpose of review: Acute myeloid leukemia (AML) survivors face unique challenges affecting long-term outcomes and quality of life. There is scant literature on the long-term impact of AML treatment in physical and mental ...
Towards a Personalized Definition of Prognosis in Philadelphia-Negative Myeloproliferative Neoplasms [0.03%]
一种在费城阴性骨髓增生异常肿瘤中个性化定义预后的方案
Barbara Mora,Francesco Passamonti
Barbara Mora
Purpose of review: Philadelphia-negative myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), prefibrotic (pre-), and overt-primary myelofibrosis (primary MF, PMF). PV and ET...
Evguenia Ouchveridze,Katherine Berger,Ghulam Rehman Mohyuddin
Evguenia Ouchveridze
Purpose of review: Despite tremendous advances in multiple myeloma (MM) care, the disease maintains considerable morbidity and requires long-term treatment associated with significant financial toxicity to patients and hi...