Financial Toxicity in Patients with Hematologic Malignancies: a Review and Need for Interventions [0.03%]
血液系统恶性肿瘤患者的财务毒性：综述及干预需求分析
Megan Sears-Smith,Thomas G Knight
Megan Sears-Smith
Introduction: Financial toxicity is a developing research area to quantify the financial stress experienced by patients and caregivers, as well as the mechanisms by which they manage the costs associated with treatment an...
Kelsey Beck,Tyler Sandahl,Sikander Ailawadhi et al.
Kelsey Beck et al.
Purpose of review: The treatment landscape of multiple myeloma (MM) has evolved resulting in MM becoming a chronic condition. The costs of MM therapies are substantial and compound as patients remain on long-term maintena...
Winnie Z Y Teo,Ian Y E Ong,Jason W Y Tong et al.
Winnie Z Y Teo et al.
Purpose of review: The development of potent novel agents has improved outcomes for patients with multiple myeloma (MM). Heterogeneity of response to therapy, an expanding arsenal of treatment options, and cost are howeve...
Nicole Held,Ehab L Atallah
Nicole Held
Purpose of review: Chronic myeloid leukemia (CML) is a disease that previously signified a poor prognosis, but treatment options and outcomes have improved over the last several decades. Despite this, challenges remain in...
A Journey Through JAK Inhibitors for the Treatment of Myeloproliferative Diseases [0.03%]
JAK抑制剂治疗髓系增生性肿瘤研究进展及展望
Andrea Duminuco,Elena Torre,Giuseppe A Palumbo et al.
Andrea Duminuco et al.
Purpose of review: Chronic myeloproliferative neoplasms (MPN) represent a group of diseases characterised by constitutive activation of the JAK/STAT pathway in a clonal myeloid precursor. The therapeutic approach aims to ...
Richter Transformation of Chronic Lymphocytic Leukemia-Are We Making Progress? [0.03%]
慢性淋巴细胞白血病的里奇尔转化-我们取得了进步吗？
Hadiyah Y Audil,Samuel R Kosydar,Daniel P Larson et al.
Hadiyah Y Audil et al.
Purpose of review: The treatment paradigm of chronic lymphocytic leukemia (CLL) has dramatically changed with the advent of novel targeted agents over the past decade. Richter transformation (RT), or the development of an...
Oluwatobi Odetola,Shuo Ma
Oluwatobi Odetola
Purpose of review: There have been significant advances in the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL) over the past two decades. However, the intention of treatment remains control of the dise...
Sporadic and Familial Acute Myeloid Leukemia with CEBPA Mutations [0.03%]
CEBPA突变的急性髓系白血病患者的临床和遗传特征：散在型与家族型比较
Ji Yuan,Rong He,Hassan B Alkhateeb
Ji Yuan
Purpose of review: CCAAT enhancer binding protein A (CEBPA) gene mutation is one of the common genetic alterations in acute myeloid leukemia (AML), which can be associated with sporadic and familial AML. ...
GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation [0.03%]
GATA2缺乏病與髓系惡性腫瘤的易感性和造血細胞移植的关系
Roma V Rajput,Danielle E Arnold
Roma V Rajput
Purpose of review: GATA2 deficiency is a haploinsufficiency syndrome associated with a wide spectrum of disease, including severe monocytopenia and B and NK lymphopenia, predisposition to myeloid malignancies, human papil...
Clonal Hematopoiesis in Myeloproliferative Neoplasms Confers a Predisposition to both Thrombosis and Cancer [0.03%]
克隆性血液细胞增多症会带来血栓和癌症的易感性
Tiziano Barbui,Antonello Gavazzi,Edoardo Sciatti et al.
Tiziano Barbui et al.
Purpose of review: This review focuses on vascular complications associated with chronic myeloproliferative neoplasms (MPN) and more specifically aims to discuss the clinical and biological evidence supporting the existen...