Transforming the Treatment of Acute Lymphoblastic Leukemia: the Role of Bispecific Antibodies, Antibody-Drug Conjugates, and CAR T-cell Therapy [0.03%]
急性淋巴细胞白血病治疗方式的变革：双特异性抗体、抗体偶联药物和CAR-T细胞治疗的作用
Tala Najdi,Sarah Khanfour,Joe Chalhoub et al.
Tala Najdi et al.
Purpose of review: B-cell acute lymphoblastic leukemia (B-ALL) is a highly aggressive hematologic malignancy, with particularly poor outcomes in relapsed or refractory cases. Relapses remain a major challenge, often resul...
Plasmacytoid Dendritic Cell-Expansion in Acute Myeloid Leukemia (pDC‑AML): a Review of Clinicopathologic Features, Genetics, and Outcomes [0.03%]
急性髓系白血病中浆细胞样树突状细胞的扩增（pDC-AML）：临床病理特征、遗传学和预后综述
Azza E A Abdalla,Mohammed Abdulgayoom,Abdulrahman F Al-Mashdali et al.
Azza E A Abdalla et al.
Purpose of review: Plasmacytoid dendritic cell-expansion in acute myeloid leukemia (pDC-AML) is an uncommon AML subset that differs from conventional AML and from blastic plasmacytoid dendritic cell neoplasm (BPDCN). This...
From MRD To Match: the Role of Allogeneic Hematopoietic Cell Transplant in Philadelphia-Negative B-ALL [0.03%]
从MRD到移植：allo-HSCT在Ph阴性B-ALL中的作用
Jessica El-Asmar,John C Molina,Betty Ky Hamilton
Jessica El-Asmar
Purpose of review: Given the high risk of relapse for Philadelphia-negative (Ph-negative) B-cell acute lymphoblastic leukemia (ALL), allogeneic hematopoietic cell transplantation (allo-HCT) is often recommended following ...
Myelodysplastic syndromes: Updates on Genomic Landscape, Molecular Subtypes, & Targeted Therapies [0.03%]
骨髓增生异常综合症：基因图谱、分子亚型及靶向治疗的新进展
Shirley S Mo,Amy E DeZern
Shirley S Mo
Purpose of review: Advances in modern molecular and genomic testing have spurred tremendous progress in our understanding of MDS pathogenesis. Here we review common diagnostic methods, the evolving multi-omics landscape o...
Splicing Factor Mutations in Chronic Myelomonocytic Leukemia: Biological Consequences and Therapeutic Implications [0.03%]
慢性嗜酸性粒细胞白血病中的剪接因子突变：生物学后果和治疗意义
Nickolas Steinauer,Mrinal M Patnaik
Nickolas Steinauer
Purpose of review: This review will summarize recent research into the diverse biological consequences of splicing factor mutations, and possible therapeutic vulnerabilities uncovered by such mutations, with a dedicated f...
Use of Patient-Reported Outcome Measures in Clinical Studies of Chronic Myeloid Leukemia: A Scoping Literature Review [0.03%]
慢性粒细胞白血病临床研究中患者报告结局的应用——系统综述式文献回顾
Kathryn E Flynn,Lovneet Saini,Aditi Kataria et al.
Kathryn E Flynn et al.
Purpose of review: Management of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors has improved patient survival. However, patient quality of life (QOL) continues to be impacted by disease symptoms and treatm...
Niraj Neupane,Eric Padron
Niraj Neupane
Purpose of review: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy characterized by monocytosis and dysplasia. While mutations in genes like TET2 and SRSF2 have helped us understand its molecul...
Emerging Significance and Implications of a Durable Complete Molecular Remission in the Treatment of Polycythemia Vera [0.03%]
持久性分子生物学完全缓解在真性红细胞增多症治疗中的重要意义及影响
Minghui Duan,Prithviraj Bose,Anthony M Hunter et al.
Minghui Duan et al.
Polycythemia vera (PV) is a Philadelphia chromosome-negative myeloproliferative neoplasm (MPN) caused by a somatic gain-of-function mutation of the Janus kinase2 (JAK2) gene in hematopoietic stem and peripheral blood cells, leading to eryth...
Jenna Fernandez,Pankaj Pradeep,Mrinal M Patnaik
Jenna Fernandez
Purpose of review: Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm that is characterized by sustained monocytic proliferation, bone marrow dysplasia, and progression to acute myeloi...
Chronic Myelomonocytic Leukemia Microenvironment in Disease Progression and Therapy: Focus on Stepwise Reconfiguring of Myeloid-Immune Cell Interactions Driving Immune Tolerance [0.03%]
慢性单核细胞白血病疾病进展和治疗中的微环境：逐步重塑髓系-免疫细胞互作导致免疫耐受的焦点问题研究
Ali Khalid A Alsugair,Abhishek Mangaonkar
Ali Khalid A Alsugair
Purpose of the review: To summarize evidence and provide an overview of the microenvironment and myeloid-immune cell interactions within the chronic myelomonocytic leukemia (CMML) microenvironment that drive mutation-agno...