Novel approaches to the immunotherapy of B-cell malignancies: An update [0.03%]
B细胞恶性肿瘤免疫治疗的新方法：最新研究进展
Renier J Brentjens
Renier J Brentjens
Immunotherapy of cancer includes both active and adoptive, or passive, forms of immunization to target and eradicate malignant B cells in the host. Advances in the understanding of immunology and tumor-cell evasion of the host immune system...
Stefan Faderl,William Wierda,Michael J Keating
Stefan Faderl
Progress in the understanding of the biology of chronic lymphocytic leukemia and in the development of new and effective therapies has generated a shift in treatment paradigms within only a few years. Traditional chemotherapy agents such as...
John W Sweetenham
John W Sweetenham
Understanding of the pathogenesis and biology of precursor T-cell and B-cell neoplasms has advanced significantly with the description of gene expression profiling studies, especially in T-cell disease. These studies have demonstrated leuke...
Treatment of Burkitt lymphoma in children and adults: Lessons from Africa [0.03%]
儿童及成人 Burkitt 淋巴瘤的治疗——来自非洲的经验教训
Ian T Magrath
Ian T Magrath
Modern chemotherapy for childhood Burkitt lymphoma has its origins in Africa, where treatment evolved from one or two doses of single agents, which were curative in some patients, to combinations of non-cross-resistant drugs. Subsequently, ...
The role of rituximab in autologous and allogeneic hematopoietic stem cell transplantation for non-Hodgkin's lymphoma [0.03%]
利妥昔单抗在自身和同种异体造血干细胞移植治疗非霍奇金淋巴瘤中的作用
Elizabeth Naparstek
Elizabeth Naparstek
The addition of rituximab to chemotherapy has substantially changed the treatment strategies for patients with B-cell lymphomas. Rituximab, combined with standard chemotherapy regimens, shows consistently improved results compared with chem...
Pierre Giglio,Mark R Gilbert
Pierre Giglio
Non-Hodgkin's lymphoma can affect the central and peripheral nervous systems. Involvement may include parenchymal or leptomeningeal metastasis, paraneoplastic involvement, or neurologic complications resulting from chemotherapy or radiation...
Benjamin Bonavida
Benjamin Bonavida
Immunotherapy with rituximab (a chimeric anti-CD20 monoclonal antibody), alone or in combination with chemotherapy, has improved the treatment outcome of patients with non-Hodgkin's lymphoma (NHL), but the in vivo mechanisms by which rituxi...
Recent advances in hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病造血干细胞移植的新进展
Veronica Jude,Ka Wah Chan
Veronica Jude
Hematopoietic stem cell transplantation has been an important treatment modality in the management of high-risk or relapsed childhood acute lymphoblastic leukemia. Analysis of its efficacy has been based mostly on stratification of patients...