Unlocking the Potential of Artificial Intelligence in Acute Myeloid Leukemia and Myelodysplastic Syndromes [0.03%]
解锁人工智能在急性髓系白血病和骨髓增生异常综合征中的潜力
Abdulrahman Alhajahjeh,Aziz Nazha
Abdulrahman Alhajahjeh
Purpose of the review: This review aims to elucidate the transformative impact and potential of machine learning (ML) in the diagnosis, prognosis, and clinical management of myelodysplastic syndromes (MDS) and acute myelo...
Experimental and Computational Approaches to Measure Telomere Length: Recent Advances and Future Directions [0.03%]
测量端粒长度的实验和计算方法：近期进展与未来方向
Alejandro Ferrer,Zachary D Stephens,Jean-Pierre A Kocher
Alejandro Ferrer
Purpose of review: The length of telomeres, protective structures at the chromosome ends, is a well-established biomarker for pathological conditions including multisystemic syndromes called telomere biology disorders. Ap...
Brian Cuzzo,Andrew Lipsky,Hua-Jay J Cherng
Brian Cuzzo
Purpose of review: The utility of analyzing circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and disease in the bone marrow as an adjunctive tool in caring for hematologic cancer patients is expanding. This ...
Updates in the Classification of T-cell Lymphomas and Lymphoproliferative Disorders [0.03%]
T细胞淋巴瘤和淋巴增生性疾病的分类更新
Naoki Oishi,Reham Ahmed,Andrew L Feldman
Naoki Oishi
Purpose of review: Mature T/NK-cell neoplasms comprise a heterogeneous group of diseases with diverse clinical, histopathologic, immunophenotypic, and molecular features. A clinically relevant, comprehensive, and reproduc...
Genetic Counseling and Family Screening Recommendations in Patients with Telomere Biology Disorders [0.03%]
染色体生物学障碍患者的遗传咨询和家庭筛查建议
Laura Ongie,Hannah A Raj,Katie Barrett Stevens
Laura Ongie
Purpose of review: Telomere biology disorders (TBDs) encompass a spectrum of genetic diseases with a common pathogenesis of defects in telomerase function and telomere maintenance causing extremely short telomere lengths....
NK Cell Therapeutics for Hematologic Malignancies: from Potential to Fruition [0.03%]
NK细胞治疗血液系统恶性肿瘤：从潜力走向现实
Stephanie L Fetzko,Leander D Timothy,Robin Parihar
Stephanie L Fetzko
Purpose of review: The current review focuses on the preclinical development and clinical advances of natural killer (NK) cell therapeutics for hematologic malignancies and offers perspective on the unmet challenges that ...
Nicholas J Short,Jayastu Senapati,Elias Jabbour
Nicholas J Short
Purpose of review: While most patients with chronic myeloid leukemia (CML) present in a chronic phase and are expected to have a normal life expectancy, some patients present with or progress to a more aggressive accelera...
Eleanor P Taranto,Stefan K Barta,Rahul S Bhansali
Eleanor P Taranto
Purpose of review: T and NK cell lymphomas are relatively rare and heterogeneous forms of non-Hodgkin lymphoma that are associated with high rates of mortality. Central nervous system relapse carries significant morbidity...
Maegan Ford,Evelyn Orlando,Jennifer Effie Amengual
Maegan Ford
Purpose of review: Epstein-Barr Virus (EBV) is a ubiquitous herpesvirus that affects almost all humans and establishes lifelong infections by infecting B-lymphocytes leading to their immortalization. EBV has a discrete li...
Developing Targeted Therapies for T Cell Acute Lymphoblastic Leukemia/Lymphoma [0.03%]
T细胞急性淋巴细胞白血病/淋巴瘤的靶向治疗研究
Adam S DuVall,Austin Wesevich,Richard A Larson
Adam S DuVall
Purpose of review: Largely, treatment advances in relapsed and/or refractory acute lymphoblastic leukemia (ALL) have been made in B cell disease leaving T cell ALL reliant upon high-intensity chemotherapy. Recent advances...