Therapeutic Targets in Myelodysplastic Neoplasms: Beyond Hypomethylating Agents [0.03%]
低甲基化药物以外的骨髓衰竭性肿瘤治疗靶点
Prateek Pophali,Sudhamsh Reddy Desai,Aditi Shastri
Prateek Pophali
Purpose of review: To discuss novel targeted therapies under investigation for treatment of myelodysplastic neoplasms (MDS). Recent findings: ...
New Molecular and Biological Markers in Cutaneous T Cell Lymphoma: Therapeutic Implications [0.03%]
皮肤T细胞淋巴瘤中的新的分子和生物学标志物：治疗意义
Daniel E Luna,Michi M Shinohara
Daniel E Luna
Purpose of review: Cutaneous T cell lymphomas (CTCLs) exhibit a wide variety of clinical features, histologic characteristics, and genetic drivers. We review novel molecular findings that inform our understanding of the p...
Nandita Khera
Nandita Khera
Purpose of review: With improvement in survival after hematopoietic cell transplantation (HCT), it has become important to focus on the late complications experienced by the survivors that may lead to late mortality and m...
Approach to the Treatment of Philadelphia Chromosome-Negative B-cell ALL in Older Adults: Is Age Becoming just a Number? [0.03%]
费城染色体阴性的B细胞急性淋巴细胞白血病在老年患者中的治疗策略：年龄只是一个数字吗？
Yuchen Liu,Vu H Duong
Yuchen Liu
Purpose of review: Despite progress in the treatment of pediatric B-cell acute lymphoblastic leukemia (ALL) and PH + ALL, fewer advancements have been for older adults with PH-negative B-cell ALL. Treatment of this popula...
CML Outcomes and Care Delivery During the COVID-19 Pandemic in Low- and Middle-Income Countries [0.03%]
低收入和中等收入国家的新冠肺炎疫情对医疗结果和护理服务的影响
Mika Matsuzaki,Alicia Annamalay,Pat Garcia-Gonzalez et al.
Mika Matsuzaki et al.
Purpose of review: The study aims to evaluate the impact of COVID-19 on the delivery of health care and services to patients with chronic myeloid leukemia in low- and middle-income countries (LMICs) accessing treatment th...
The Bone Marrow Immune Microenvironment in CML: Treatment Responses, Treatment-Free Remission, and Therapeutic Vulnerabilities [0.03%]
慢性粒细胞白血病的骨髓免疫微环境：治疗反应、停药缓解和治疗弱点
Shaun David Patterson,Mhairi Copland
Shaun David Patterson
Purpose of review: Tyrosine kinase inhibitors (TKIs) are very successful for the treatment of chronic myeloid leukaemia (CML) but are not curative in most patients due to persistence of TKI-resistant leukaemia stem cells ...
Ellin Berman
Ellin Berman
Purpose of review: The goal of this review is to summarize what is known about pregnancy in women with chronic myeloid leukemia (CML): there are very few guidelines regarding how to treat women who are pregnant at the tim...
Karan L Chohan,Elizabeth L Siegler,Saad S Kenderian
Karan L Chohan
Purpose of review: Chimeric antigen receptor (CAR) T cell therapy is an immunotherapy that has resulted in tremendous progress in the treatment of patients with B cell malignancies. However, the remarkable efficacy of the...
Evan C Chen,Hannah Johnston,Anand Ashwin Patel
Evan C Chen
Purpose of review: JAK inhibition is an effective means of controlling symptom burden and improving splenomegaly in patients with myeloproliferative neoplasms (MPNs). However, a majority of patients treated with JAK inhib...
The Role of Belantamab Mafodotin, Selinexor, and Melflufen in Multiple Myeloma [0.03%]
在多发性骨髓瘤中贝兰塔马福度汀、塞利奈索和美法仑的作用
Arleigh McCurdy,Alissa Visram
Arleigh McCurdy
Purpose of review: Multiple myeloma (MM) is a hematologic malignancy of plasma cells that remains incurable with currently available therapies including proteosome inhibitors, immunomodulators, monoclonal antibodies, cort...