Winnie Z Y Teo,Ian Y E Ong,Jason W Y Tong et al.
Winnie Z Y Teo et al.
Purpose of review: The development of potent novel agents has improved outcomes for patients with multiple myeloma (MM). Heterogeneity of response to therapy, an expanding arsenal of treatment options, and cost are howeve...
Nicole Held,Ehab L Atallah
Nicole Held
Purpose of review: Chronic myeloid leukemia (CML) is a disease that previously signified a poor prognosis, but treatment options and outcomes have improved over the last several decades. Despite this, challenges remain in...
A Journey Through JAK Inhibitors for the Treatment of Myeloproliferative Diseases [0.03%]
JAK抑制剂治疗髓系增生性肿瘤研究进展及展望
Andrea Duminuco,Elena Torre,Giuseppe A Palumbo et al.
Andrea Duminuco et al.
Purpose of review: Chronic myeloproliferative neoplasms (MPN) represent a group of diseases characterised by constitutive activation of the JAK/STAT pathway in a clonal myeloid precursor. The therapeutic approach aims to ...
Richter Transformation of Chronic Lymphocytic Leukemia-Are We Making Progress? [0.03%]
慢性淋巴细胞白血病的里奇尔转化-我们取得了进步吗？
Hadiyah Y Audil,Samuel R Kosydar,Daniel P Larson et al.
Hadiyah Y Audil et al.
Purpose of review: The treatment paradigm of chronic lymphocytic leukemia (CLL) has dramatically changed with the advent of novel targeted agents over the past decade. Richter transformation (RT), or the development of an...
Oluwatobi Odetola,Shuo Ma
Oluwatobi Odetola
Purpose of review: There have been significant advances in the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL) over the past two decades. However, the intention of treatment remains control of the dise...
Sporadic and Familial Acute Myeloid Leukemia with CEBPA Mutations [0.03%]
CEBPA突变的急性髓系白血病患者的临床和遗传特征：散在型与家族型比较
Ji Yuan,Rong He,Hassan B Alkhateeb
Ji Yuan
Purpose of review: CCAAT enhancer binding protein A (CEBPA) gene mutation is one of the common genetic alterations in acute myeloid leukemia (AML), which can be associated with sporadic and familial AML. ...
GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation [0.03%]
GATA2缺乏病與髓系惡性腫瘤的易感性和造血細胞移植的关系
Roma V Rajput,Danielle E Arnold
Roma V Rajput
Purpose of review: GATA2 deficiency is a haploinsufficiency syndrome associated with a wide spectrum of disease, including severe monocytopenia and B and NK lymphopenia, predisposition to myeloid malignancies, human papil...
Clonal Hematopoiesis in Myeloproliferative Neoplasms Confers a Predisposition to both Thrombosis and Cancer [0.03%]
克隆性血液细胞增多症会带来血栓和癌症的易感性
Tiziano Barbui,Antonello Gavazzi,Edoardo Sciatti et al.
Tiziano Barbui et al.
Purpose of review: This review focuses on vascular complications associated with chronic myeloproliferative neoplasms (MPN) and more specifically aims to discuss the clinical and biological evidence supporting the existen...
Pelabresib (CPI-0610): An Exciting Novel Drug for the Treatment of Myelofibrosis [0.03%]
普拉贝利西布(CPI-0610)——治疗骨髓纤维化的新药曙光
Guadalupe Ferreira Gomes,Claire Harrison
Guadalupe Ferreira Gomes
Purpose of review: Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by bone marrow fibrosis, megakaryocyte atypia, and inflammatory cytokine overproduction, resulting in progressive cytopenias, splenomega...
A Pragmatic Approach to Managing Long-Term Adverse Effects in Chronic Myeloid Leukemia Treatment [0.03%]
慢性粒细胞白血病治疗中管理长期不良反应的实用方法
Josephine Anne Lucero,Jeffrey H Lipton
Josephine Anne Lucero
Purpose of review: Long-term outcomes have significantly improved with treatment of chronic myeloid leukemia. With proper treatment, most patients will achieve similar survival rates compared to an age-matched population....