Telomere Biology Disorder: A Focus on Gastrointestinal and Hepatic Manifestations [0.03%]
端粒生物学障碍：聚焦胃肠和肝脏表现形式
Fatima Warsame,Douglas A Simonetto
Fatima Warsame
Purpose of review: Telomere biology disorders (TBD) encompass several illnesses caused by underlying mutations in telomere maintenance leading to premature telomere attrition and telomere dysfunction. These disorders have...
Catherine C Coombs
Catherine C Coombs
Purpose of review: The therapeutic landscape for chronic lymphocytic leukemia (CLL) has undergone a complete makeover following the introduction of highly effective targeted therapies, beginning with ibrutinib which first...
Richard J Lin,Parastoo B Dahi,Beatriz Korc-Grodzicki et al.
Richard J Lin et al.
Purpose of review: Hematologic malignances more commonly affect older individuals and often present with advanced, higher risk disease than younger patients. Allogeneic and autologous hematopoietic cell transplantation is...
Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders [0.03%]
端粒生物学障碍患者肺部、肝脏和同种异体造血干细胞移植
Kelly M Pennington,Douglas Simonetto,Timucin Taner et al.
Kelly M Pennington et al.
Purpose of the review: This study aimed to summarize evidence and provide consensus-based guidelines for management of transplantation in patients with telomere biology disorders (TBD). Specifically, this review focuses o...
Parathan Karunakaran,Nidhi Jain,Deepesh P Lad
Parathan Karunakaran
Purpose of review: Chronic lymphocytic leukemia was an ignored leukemia in India until a decade back, given its low prevalence and absence of novel drugs to treat it. Healthcare in India is heterogeneous, with variations ...
Amneet Bajwa,Alma Habib,Adam S Kittai
Amneet Bajwa
Purpose of review: This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter's transformation (RT). ...
Diagnosis and Management of Pulmonary Manifestations of Telomere Biology Disorders [0.03%]
端粒生物学障碍的肺表现的诊断和管理
Kathryn T Del Valle,Eva M Carmona
Kathryn T Del Valle
Purpose of review: Telomere biology disorders (TBD) are a group of genetic disorders characterized by premature shortening of telomeres, resulting in accelerated aging of somatic cells. This often leads to major multisyst...
Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders [0.03%]
端粒病的适应性和非适应性克隆造血功能
Terra Lasho,Mrinal M Patnaik
Terra Lasho
Purpose of review: Telomere biology disorders (TBDs) are germline-inherited conditions characterized by reduction in telomerase function, accelerated shortening of telomeres, predisposition to organ-failure syndromes, and...
Jeffrey Lantz,Natalie Pham,Caroline Jones et al.
Jeffrey Lantz et al.
Purpose of review: Acute lymphoblastic leukemia (ALL) is a rare hematologic neoplasm in adults, with most cases defined by pathology related to abnormal B cell proliferation known as B-cell ALL. The course is challenging,...
Hong De Sa,Jessica Leonard
Hong De Sa
Purpose of review: Acute lymphoblastic leukemia (ALL) is a widely heterogeneous disease in terms of genomic alterations, treatment options, and prognosis. While ALL is considered largely curable in children, adults tend t...